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Using Your Nervous System to Enhance Your Immune System

Episode 44 Nov 1, 2021 1h 57m 12 insights
This episode teaches you a lot about the immune system, immune-brain interactions and offers 12 potential tools for enhancing immune system function. I discuss how our immune system works and science-supported tools we can use to enhance our immune system. I discuss the innate and adaptive immune systems and our various microbiomes-- not just in our gut but also in our nose, eyes and mouth and how to keep them healthy. And I review how specific patterns of breathing and foods maintain a healthy mucosal barrier that is crucial for fighting infections. I discuss how certain neurochemicals called catecholamines enhance our immune system function and how to use specific breathing protocols, types and timing of heat and cold exposure, and, if appropriate, supplementation to activate catecholamines. I also discuss the role and use of serotonin for the sake of accessing the specific types of sleep for recovering from illness, and I discuss how to increase glymphatic "washout" of brain debris during sleep. I also review fever, the vagus nerve and the use of atypical yet highly effective compounds for rhinitis (nasal inflammation). Read the full show notes for this episode at hubermanlab.com.
Actionable Insights

1. Cyclic Hyperventilation for Immunity

Perform 3 rounds of 25-30 deep inhales and exhales through the mouth, followed by an exhale and a breath hold for 15-60 seconds, to increase anti-inflammatory cytokines and reduce pro-inflammatory ones. This behavioral protocol activates the sympathetic nervous system and releases adrenaline, enhancing the immune response and reducing flu-like symptoms. (Caution: Do not practice near water or while driving; breathe when the impulse arises).

2. Cultivate Hope for Healing

Actively engage in thinking about a positive future, as this activates the dopamine reward pathway, which can reduce tumor size, accelerate wound healing, and quicken recovery from illness and injury.

3. Elevate Feet for Glymphatic Clearance

During sleep or deep relaxation, elevate your feet by about 12 degrees (e.g., with pillows) to enhance the glymphatic system’s washout of debris from the brain. This increased clearance is crucial for recovery from infection and injury.

4. Early Illness Heat Exposure

At the initial stage of an infection (without a fever), engage in a 15-minute sauna session or a very hot bath/shower to increase white blood cell profiles and adjust cortisol levels beneficially. For maximal effects, alternate 15 minutes of heating with 5-10 minutes of cooling to force repeated pulses of cortisol-lowering and white cell-stimulating signals. (Caution: Do not use if already running a fever, as it could lead to dangerously high body temperatures).

5. Consume Fermented Foods Daily

Ingest two to four servings of low-sugar fermented foods daily (e.g., sauerkraut, kimchi) to maintain a healthy gut microbiome. A healthy microbiome reduces inflammatory cytokines and strengthens the mucus lining defense against pathogens.

6. Prioritize Nasal Breathing

Whenever possible, breathe through your nose instead of your mouth, as the nose acts as a superior filter for viruses and bacteria. Nasal breathing also helps dilate sinuses, enhancing this protective function.

7. Practice Strict Hand-Eye Hygiene

Avoid touching your eyes, especially after touching other people or surfaces, because the eyes are a primary entry point for many bacteria and viruses.

8. Allow Functional Fevers

Avoid immediately lowering a fever with drugs unless body temperature reaches dangerously high levels, as fever is the body’s natural adaptive response to heat up and kill off invaders. Eating during a fever can further increase body temperature through the thermogenic effect of food.

9. Augment Dopamine for Recovery

To potentially accelerate healing and recovery from injury, consider behavioral methods like 3-10 minutes of uncomfortable cold water exposure (which can double dopamine levels for several hours). Alternatively, after consulting a doctor, supplements like L-tyrosine (500-750mg) or Mucuna Pruriens can be explored as dopamine precursors. (Caution: Not recommended for individuals with bipolar disorder, mania, or schizophrenia).

10. Serotonin for Sickness Sleep

If experiencing early illness, and after consulting a doctor, consider taking 300-500mg of 5-HTP 30-60 minutes before sleep to enhance a specific quality of sleep associated with a robust immune response. (Caution: Not for regular use, as it can disrupt normal sleep architecture; always consult a doctor).

11. Spirulina for Congestion Relief

Take two grams of spirulina to reduce symptoms of rhinitis (nasal congestion and inflammation), as it can inhibit the formation and activity of histamine-releasing mast cells. (Caution: Not for individuals with a genetic mutation leading to PKU; consult a doctor).

12. Foundational Health Practices

Ensure adequate, high-quality, consistent sleep (80-90% of the time), get morning and evening sunlight, engage in 150-180 minutes of Zone 2 cardio weekly, eat well by avoiding processed foods, maintain social connections, and stay properly hydrated. These practices form the bedrock of overall mental and physical health.