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Psychedelics for Treating Mental Disorders | Dr. Matthew Johnson

Episode 38 Sep 20, 2021 2h 49m 18 insights
This episode I discuss medical research on psychedelic compounds with Dr. Matthew Johnson, Ph.D., Professor of Psychiatry and Behavioral Sciences at Johns Hopkins School of Medicine. We discuss the biology and medical clinical-trial uses of psilocybin, MDMA, ayahuasca, DMT, and LSD. Dr. Johnson teaches us what the clinical trials in his lab are revealing about the potential these compounds hold for the treatment of depression, addiction, trauma, eating disorders, ADHD, and other disorders of the mind. Dr. Johnson describes a typical psychedelic experiment in his laboratory, start to finish, including the conditions for optimal clinical outcomes. And he explains some of the potential hazards and common misconceptions and pitfalls related to psychedelic medicine. Dr. Johnson explains flashbacks, the heightened risks of certain people and age groups using psychedelics and the ever evolving legal and pharmaceutical industry landscape surrounding psychedelics. Dr. Johnson also explains how the scientific study of psychedelics is likely to set the trajectory of psychiatric medicine in the years to come. Dr. Johnson is among a small handful of researchers who have pioneered the clinical study of these powerful compounds. He has unprecedented insight into how they can be woven into other psychiatric treatments, changing ones sense of self and of reality. Read the full show notes for this episode at hubermanlab.com.
Actionable Insights

1. Prioritize Experience for Brain Change

Recognize that deep changes in neural circuitry, emotionality, and self-perception primarily occur through real, impactful somatic and perceptual experiences, not merely through language or affirmations. This understanding helps avoid the “treacherous” trap of believing one can simply talk oneself out of deeply ingrained psychological states.

2. Screen for Psychiatric Predisposition

Before considering psychedelics, undergo extensive screening for severe psychiatric illnesses like psychotic disorders (schizophrenia) or mania (bipolar disorder), including family history. This is critical to mitigate the risk of profound destabilization.

3. Ensure Safe Psychedelic Environment

If considering psychedelics, ensure they are taken in a safe, controlled environment, ideally with sober, supportive individuals. Avoid navigating complex or unfamiliar environments to enhance safety and manage potential challenges.

4. Practice Letting Go During Psychedelics

During a psychedelic experience, actively practice letting go of control and surrendering to the experience. This approach can be a gateway to transcendental experiences and positive long-term outcomes, whereas resisting the experience can lead to a “bad trip.”

5. Post-Psychedelic Major Decision Delay

After a psychedelic experience, wait at least two weeks before making any major life decisions, such as ending relationships, quitting jobs, starting new relationships, or getting pets. This allows your sober mind to process insights and make well-considered choices.

6. Allow All Emotional Responses

In a therapeutic psychedelic session, allow any emotional response, including intense crying, to manifest freely. This is encouraged to facilitate the experience and is part of the therapeutic process.

7. Utilize Eye Shades for Internal Focus

During a psychedelic experience, use eye shades to enhance the “mind’s eye” and deepen internal perceptual experiences. This can help focus on the internal journey.

8. Process Experience Through Writing & Integration

Following a psychedelic session, write down your experience without self-criticism and participate in a subsequent integration session with guides. This helps process the experience and discuss its meaning for lasting benefit.

9. Understand Psychedelic Variability

Be aware that psychedelic experiences are highly variable and can range from profoundly beautiful to terrifying. Managing expectations by understanding this variability is crucial to avoid surprises.

10. Skepticism on Microdosing Claims

Be skeptical of claims that microdosing significantly increases creativity, enhances cognition, or provides sustained mood improvement, as current peer-reviewed, double-blind studies have not shown consistent benefits and sometimes indicate impairment.

11. Caution with Chronic Microdosing

Exercise caution with long-term, frequent microdosing (e.g., twice a week for years) due to theoretical concerns about serotonin 2B agonist effects, which have been linked to heart valve problems. While infrequent therapeutic use may not pose a risk, chronic use could.

12. Take Athletic Greens Daily

Consider taking Athletic Greens once or twice a day to cover basic nutritional needs, address potential deficiencies, and support microbiome health with probiotics.

13. Ensure Proper Hydration & Electrolytes

Prioritize proper hydration and adequate electrolyte intake (sodium, magnesium, potassium) daily. This is critical for optimal brain and body function, preventing diminished cognitive and physical performance, and supporting cell/neuron function.

14. Hydration Routine with Element

Dissolve one packet of Element in 16-32 ounces of water and drink it first thing in the morning, and also during any physical exercise. This routine helps ensure proper hydration and electrolyte balance.

15. Practice Yoga Nidra or NSDR

Incorporate yoga nidra or non-sleep deep rest (NSDR) into your routine, even for short 10-minute sessions. This practice can greatly restore cognitive and physical energy.

16. Access Waking Up App for Meditation

Use the Waking Up app to explore various meditation programs, mindfulness trainings, yoga nidra, and NSDR protocols. This allows for placing the brain and body into different states and restoring energy.

17. Verify Drug Information Scientifically

Do not attribute bizarre behaviors or negative effects to unfamiliar drugs without scientific evidence. Misinformation and xenophobia can lead to incorrect and harmful conclusions.

18. Find Clinical Trials for Psychedelics

To explore participation in Dr. Matthew Johnson’s clinical trials, visit hopkinspyschedelic.org. For broader psychedelic clinical trials in the US and Europe, search clinicaltrials.gov. Apply through official portals for specific, FDA-approved protocols.