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Nutrients for Brain Health & Performance

Episode 42 Oct 18, 2021 1h 37m 18 insights
This episode I describe science-supported nutrients for brain and performance (cognition) and for nervous system health generally. I describe 10 tools for this purpose, including specific amounts and sources for Omega-3 fatty acids which make up the "structural fat" of neurons (nerve cells) and allow them to function across our lifespan. I also review data on creatine, phosphatidylserine, anthocyanins, choline, glutamine and how they each impact brain function in healthy people seeking to reinforce and improve their cognition and in those combatting cognitive decline. I describe both food-based and supplement-based sources for these compounds, and their effective dose ranges based on peer-reviewed literature. Then I review the 3 factors: gut-brain signaling, perceived taste, and learned associations that combine with the metabolic and blood-sugar-elevating effects of food to determine what foods we seek and prefer. Amazingly, it's not just about what tastes good to us. Next, I explore how we can leverage the neural circuits of learned food preference toward seeking and enjoying the right foods for brain health and performance. I also review new data on non-caloric sweeteners and why consuming them with glucose-elevating foods can be detrimental, in some cases rapidly leading to insulin dysregulation. This episode covers more than 10 actionable tools for those seeking to improve and/or maintain brain function, and it explains modern neuroscience underlying of our sense of taste, our food seeking preferences and brain metabolism. Read the full show notes for this episode at hubermanlab.com.
Actionable Insights

1. Prioritize Quality & Ample Sleep

Make sure to get quality and ample sleep on a regular basis, as it is the foundation of all mental and physical health, directly impacting focus, learning, and long-term brain health.

2. Engage Regular Cardiovascular Exercise

Aim for 150-180 minutes of cardiovascular exercise per week to support heart health, which is crucial for delivering oxygen and glucose to the brain and maintaining its function.

3. Ensure Proper Hydration & Electrolytes

Drink adequate water and ensure sufficient intake of electrolytes (sodium, magnesium, potassium), for instance by dissolving one packet of Element in 16-32 ounces of water first thing in the morning and during exercise, as they are vital for optimal brain and body function, including the electrical activity of neurons.

4. Rewire Food Preferences for Health

To develop a preference for healthy foods you don’t currently enjoy, pair them with foods that increase brain metabolism within the same meal for 7-14 days; this leverages the brain’s reward system to make healthy foods more palatable and desirable over time.

5. Leverage Belief for Physiological Response

Consciously adopt the belief that healthy foods are beneficial for your brain metabolism and overall health, as your subjective thoughts can directly influence physiological responses like blood sugar and insulin.

6. Manage Artificial Sweetener Consumption

If you consume artificial sweeteners, do so away from any foods that raise blood glucose levels, as pairing them can disrupt blood sugar management by increasing insulin release and potentially leading to pre-diabetic states.

7. Consume Omega-3s (EPA) Daily

Ingest 1.5-3 grams of EPA daily, either through foods like fatty fish (mackerel, salmon, herring, oysters, sardines, anchovies, caviar), chia seeds, walnuts, soybeans, or supplementation, to support neuron structure, enhance mood, and maintain cognitive function.

8. Consume Ample Choline Daily

Strive for 500-1000 milligrams of choline per day from sources like eggs (especially yolks), potatoes, nuts, seeds, grains, fruit, or certain fish, as it is vital for producing acetylcholine, which enhances focus and alertness.

9. Consume Phosphatidylserine Daily

Obtain phosphatidylserine from meats, fish, or cabbage, or supplement with 300mg per day, as it directly supports neuronal function, improves cognition, and reduces cognitive decline.

10. Supplement Creatine for Brain

Consume 5 grams of creatine monohydrate daily, either from meat sources or supplementation, to enhance brain function, utilize it as a fuel source, and potentially aid mood regulation and motivation.

11. Consume Anthocyanin-Rich Dark Berries

Eat 60-120 grams of fresh dark berries (blueberries, blackberries, black currants) daily, or supplement with 400-600mg (or 5.5-11g for higher efficacy) of anthocyanin extract, to improve brain function, reduce DNA damage, and mitigate cognitive decline.

12. Consume Glutamine for Cognition

Ingest glutamine from protein-rich foods (cottage cheese, beef, chicken, fish, dairy, eggs, beans, cabbage, spinach, parsley) or supplement with 1-10 grams per day, as it can help offset sugar cravings and mitigate cognitive deficits associated with oxygen deprivation (like sleep apnea) by reducing inflammation.

13. Maintain Healthy Gut Microbiome

Ingest 2-4 servings of low-sugar fermented foods daily, such as natto or sauerkraut, to enhance the gut’s mucosal lining and support beneficial microbiota that promote healthy food seeking signals to the brain.

14. Implement Time-Restricted Feeding Protocol

Begin your feeding window at least one hour after waking and end it 2-3 hours before sleep, maintaining this window at roughly the same time each day, to benefit weight management, fat loss, organ health, sleep quality, and cognition.

15. Consider All-in-One Nutritional Supplement

Consider taking an all-in-one vitamin-mineral-probiotic drink like Athletic Greens once or twice daily to cover basic nutritional needs, address potential deficiencies, and support microbiome health.

16. Supplement Vitamin D3K2 Daily

Supplement with Vitamin D3K2, as D3 is essential for various aspects of brain and body health (many are deficient), and K2 regulates cardiovascular function and calcium in the body.

17. Utilize Waking Up Meditation App

Use the Waking Up app for various meditation programs, mindfulness training, yoga nidra, or non-sleep deep rest (NSDR) protocols to place your brain and body into different states and restore cognitive and physical energy.

18. Consider Alpha-GPC Supplementation

Consider supplementing with 300mg of alpha-GPC 2-3 times per week, preferably early in the day, to enhance choline function and support the acetylcholine pathway for focus.