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Intermittent Fasting to Improve Health, Cognition & Longevity | Dr. Satchin Panda

Episode 115 Mar 13, 2023 2h 44m 21 insights
In this episode, my guest is Satchin Panda, PhD, professor and the director of the Regulatory Biology Laboratories at the Salk Institute for Biological Studies. We discuss his lab’s discovery that “time-restricted eating” (TRE) aka intermittent fasting, is beneficial effects for metabolic health and longevity. Dr. Panda explains how TRE, and also longer fasts, can positively impact obesity, diabetes, cardiovascular health, age-related chronic diseases, and improve mood and cognitive performance. He also describes how the timing of eating, light exposure and exercise that ~50% of all people engage in, negatively impacts their health and explains how specific simple adjustments to these can positively shift their subjective feelings of health and biomarkers of cardiovascular function, glucose regulation and metabolism. We discuss how our circadian behaviors, which include our patterns of eating, sleeping and socializing, have an enormous impact on our biology, mood and health and how by simply confining our calorie consumption to a semi-regular daily window, can positively impact our physical health, mental health and longevity. For the full show notes, visit hubermanlab.com.
Actionable Insights

1. Consistent Daily Eating Window

Confine all energy intake from solid and liquid food within a consistent window of 8 to 12 hours daily. This consistency helps various organs involved in digestion anticipate food and get ready, improving digestion and overall physiological function.

2. Avoid Late Night Meals

Avoid eating late at night, especially heavy meals, because the intestine’s peristaltic action slows down, leading to poor digestion and a ‘food hangover.’ Healthy food consumed at the wrong time can be detrimental to health.

3. Optimal 8-12 Hour Eating Window

Aim for an 8 to 10-hour eating window as an ideal starting point for time-restricted eating. For physically active individuals or those combining it with better nutrition, extending to a 12-hour window can still provide benefits and help avoid adverse effects like Relative Energy Deficit in Sports (RED-S).

4. Consistent Sleep Schedule

Strive for consistency in bedtime and wake-up times, aiming for at least 80% of nights to maintain a regular sleep-wake cycle. This consistency helps align internal clocks, leading to more restorative sleep and better daytime function.

5. Minimize Evening Bright Light

Minimize exposure to bright artificial light, especially blue-shifted light, in the evening and at night. Using red-shifted light bulbs can reduce the cortisol-releasing properties of light at night, supporting better sleep and circadian rhythm alignment.

6. Prioritize Early Bedtime

Aim to go to sleep earlier in the evening, ideally within 3-4 hours after sunset. This practice supports the natural rise of melatonin and alignment of core body temperature, leading to more restorative sleep and better morning alertness.

7. Combine TRF with Healthy Habits

Combine time-restricted eating with physical exercise and improved nutrition quality (e.g., reducing ultra-processed foods) for enhanced health benefits. This integrated approach can lead to better outcomes than focusing on one aspect alone.

8. Calorie Timing for Longevity

The timing of when calories are consumed within the 24-hour cycle is crucial for longevity, beyond just total caloric intake. Studies in mice show significantly longer lifespans when calories are consumed during the active cycle, rather than distributed throughout the day and night.

9. Prevent Energy Deficit in Athletes

Physically active individuals should be cautious about severely restricting eating intervals (e.g., to one meal a day or very short windows) to avoid Relative Energy Deficit in Sports (RED-S). RED-S can negatively impact bone health, hormonal balance (e.g., amenorrhea in women), and mental health.

10. Reduce Frequent Snacking

Be aware that frequent snacking throughout the day (median 7 times, up to 12 times for some adults) can significantly extend the eating window. Reducing the frequency of food intake can help narrow the eating window and promote the benefits of fasting.

11. Consistent Eating for Shift Workers

Shift workers, or anyone with disrupted sleep schedules, should strive for a consistent 10-hour eating window daily, even on non-working days. This consistency can significantly improve health parameters like blood pressure and blood glucose management, similar to the effects of medication.

12. Delay Caffeine for Gut Health

Individuals prone to acid reflux or heartburn should consider delaying their first caffeine intake until after consuming some food. Caffeine on an empty stomach can trigger excess acid production and discomfort.

13. Delay Caffeine for Anxiety

Individuals experiencing anxiety or panic attacks should be mindful of caffeine intake, especially on an empty stomach, as it can act as a trigger and exacerbate these symptoms.

14. Mindful Evening Activities

Be mindful of activities between sunset and bedtime, as this period significantly impacts overall health. Engage in decompressing, socializing, and expressive activities, rather than solely work-related tasks or excessive screen time, to support mental well-being and prepare for sleep.

15. Reduce Evening Alcohol Intake

Reduce alcohol intake, especially in the evening, as it can disrupt health, contribute to metabolic issues, sleep disruption, and increased anxiety. Time-restricted eating can inadvertently help reduce evening alcohol consumption.

16. 12-Hour Eating Window for Youth

Children and teenagers should ideally maintain a 12-hour eating window. This aligns with recommendations for their sleep duration (9-11 hours) and allows for proper digestion before bedtime and after waking.

17. Time-Restricted Eating Simplifies Intake

For many, time-restricted feeding (eating within a specific window) is a convenient and effective way to manage calorie intake compared to daily calorie counting, which can be difficult to maintain long-term.

18. Challenge ‘Night Owl’ Identity

Re-evaluate the self-identification as a ’night owl,’ as studies suggest that in natural light environments, most people align to similar sleep-wake schedules. Modern artificial lighting and habits often shift sleep later, which may not be optimal for health.

19. Adjust Student Assignment Deadlines

Educators should consider setting assignment deadlines earlier than midnight to avoid inadvertently encouraging students to stay up late, disrupting their sleep schedules and potentially impacting their health and academic performance.

20. Ensure Adequate Electrolyte Hydration

Ensure adequate hydration and electrolyte intake (sodium, magnesium, potassium) in correct ratios, especially upon waking and during physical exercise, to support optimal brain and body function and prevent diminished cognitive and physical performance.

21. Cover Foundational Nutrition

Consider a vitamin-mineral probiotic drink to cover foundational nutritional needs, support gut health, and ensure optimal functioning of the immune system and other biological systems.