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Improving Male Sexual Health, Function & Fertility | Dr. Michael Eisenberg

Episode 149 Nov 6, 2023 2h 34m 41 insights
In this episode, my guest is Dr. Michael Eisenberg, MD, a urologist and professor specializing in male sexual function and fertility at Stanford University. Based on his clinical work and research, he is considered a top world expert on male sexual and reproductive health. We discuss testosterone levels and what really impacts them, testosterone therapy, sperm quality and counts, penile and testicular health and function, pelvic floor and prostate and urinary tract health, erectile function and dysfunction and the various causes and treatments for common male sexual, hormonal and reproductive challenges. We also address post-finasteride syndrome and trends in penile length. This episode is rich in actionable information about men’s sexual and reproductive health, including key tests and at-home evaluations, and the behavioral, nutritional, exercise and prescription-based tools that can support male sexual and reproductive health. For show notes, including referenced articles and additional resources, please visit hubermanlab.com. Use Ask Huberman Lab, our new AI-powered platform, for a summary, clips, and insights from this episode.
Actionable Insights

1. Prioritize Overall Health

Take ownership of your overall health, as comorbid conditions like obesity, hypertension, and hyperlipidemia are linked to a decline in testicular function, including lower testosterone and sperm quality.

2. Maintain Healthy Body Weight

Maintain a healthy body weight, as there is a strong link between a man’s reproductive function and body weight, with obesity potentially contributing to declining sperm quality and testosterone.

3. Optimize Sleep Duration

Aim for 7 to 9 hours of sleep per night, as both too little and too much sleep can lead to lower semen quality and negatively impact broad testicular function.

4. Increase Daily Physical Activity

Increase your daily physical activity, such as step count, as being more active is associated with higher testosterone levels and improved testicular function.

5. Hydrate with Electrolytes Daily

Dissolve one packet of Element (electrolytes) in 16-32 ounces of water first thing in the morning and during physical exercise to ensure proper hydration and electrolyte balance, which is critical for optimal brain and body function.

6. Minimize Chemical Exposure

Avoid exposure to chemicals like phthalates and BPA, as preclinical studies suggest they may harm reproductive function in both men and women.

7. Avoid Smoking

Do not smoke, as numerous studies link smoking to lower sperm quality across all measures and a longer time to achieve pregnancy.

8. Avoid Illicit Drug Use

Avoid illicit drug use, as it can negatively affect semen quality.

9. Limit Daily Cannabis Use

Limit or avoid daily cannabis use, as studies show it can lead to significantly lower sperm concentration, motility, and morphology.

10. Moderate Alcohol Consumption

Moderate alcohol intake, as very high levels (above 20 drinks a week) have shown some negative effects on semen quality, though the association is less strong than with smoking.

11. Monitor Alcohol Flushing Response

If you experience skin flushing when consuming alcohol, be aware that alcohol may have more harmful effects on your sperm parameters due to genetic variations in alcohol metabolism.

12. Minimize Scrotal Heat Exposure

Avoid external heat sources to the scrotum, such as hot tubs, saunas, and potentially seat warmers, as testicles need to be cooler for optimal sperm production.

13. Cool Scrotum in Sauna

If using a hot sauna for 20 minutes or more, consider using a cold pack in the groin area to cool the scrotum and potentially mitigate negative effects on sperm production, being careful to avoid frostbite.

14. Avoid Laptop on Lap

Place laptops on a desk rather than directly on your lap to minimize heat exposure to the testicles, as heat can negatively impact sperm production.

15. Moderate Cycling, Stand Periodically

Limit cycling to less than five hours a week and stand up in the saddle periodically to dissipate heat, as prolonged saddle time can lower sperm counts.

16. Adjust Cycling for Discomfort

If experiencing pain, numbness, or sexual dysfunction from cycling, consider changing saddles or riding style to minimize pressure on blood flow and nerve supply to the penis.

17. Get Testosterone & Semen Screened

Get screened for testosterone levels and semen quality, as these are important barometers of overall health and cannot be predicted by appearance alone.

18. Test Sperm; Don’t Assume Health

Do not assume your sperm are healthy simply because you can ejaculate; a formal test is the only way to know sperm concentration, movement, and shape, as many men have low or absent sperm without knowing.

19. Obtain Baseline Sperm Analysis

Consider getting a sperm analysis in your 20s or 30s to establish a baseline, as more information is always good and it can serve as an early indicator of overall health.

20. Consider Sperm Cryopreservation

If you are an older father (e.g., over 40) or plan to delay conception, consider freezing sperm due to potential age-related genetic and epigenetic changes that may increase risks for offspring.

21. Understand Testosterone Therapy Risks

Be aware that testosterone therapy can significantly lower sperm production and should be considered carefully, especially for men of reproductive age, and discuss this with your provider.

22. HCG with Testosterone Therapy

If on testosterone therapy and concerned about fertility, a low dose of HCG (500-1000 units every other day) can be used to stimulate endogenous sperm production.

23. Clomiphene for Low Testosterone

Clomiphene, an off-label selective estrogen receptor modulator, can augment the body’s own testosterone production without suppressing sperm production, making it a worthwhile treatment for reproductive-age men with symptomatic low testosterone.

24. FSH for Sperm Production

Follicle-stimulating hormone (FSH) can increase sperm production and is a more logical treatment than HCG for this purpose, but its high cost ($2000-$3000/month) often limits its use.

25. Caution with DHT Blockers

Exercise extreme caution when considering finasteride or dutasteride for hair loss, as these drugs can cause sexual dysfunction, low libido, and a potentially permanent ‘post-finasteride syndrome’ in some men, even after cessation.

26. Monitor Estrogen Levels

Monitor estrogen levels, especially if obese, as excessive aromatization of testosterone to estrogen can lead to issues like gynecomastia.

27. Check Prolactin for Low T/Sperm

If experiencing symptoms of low testosterone, sexual dysfunction, or very low sperm production, get prolactin levels checked, as hyperprolactinemia can be a rare but treatable cause.

28. Consult Doctor for Dysfunction

If experiencing abnormal sexual function (e.g., not getting normal erections) or bothersome urinary symptoms (e.g., frequent night urination, weak stream), consult a physician for evaluation.

29. ED Signals Broader Vascular Risk

If experiencing erectile dysfunction, even if resolved with medication, see a primary care doctor to be screened for underlying vascular issues like high blood pressure, abnormal lipid levels, and fasting blood glucose, as ED can be an early marker for broader cardiovascular disease.

30. Treat ED with Oral Therapy

For erectile dysfunction (ED) primarily caused by blood flow issues (not hormonal), first-line treatment often involves oral PDE5 inhibitors like sildenafil (Viagra) or tadalafil (Cialis), which help 60-70% of men.

31. Consider Low-Dose Tadalafil for Urinary

For men bothered by urinary symptoms, low-dose tadalafil (2.5-5mg daily) can help improve these symptoms and also offers the added benefit of improving erectile function.

32. Manage Fluid Intake for Prostate

To manage urinary symptoms related to prostate enlargement, avoid drinking a lot before bed, and be aware that spicy foods, acidic foods, caffeine, and alcohol can irritate the bladder and increase urination frequency.

33. Evaluate Persistent Split Urine Stream

If you consistently experience a split urine stream, consult a physician for evaluation, as it could signal a urethral or prostatic issue that can be improved.

34. Evaluate for Varicocele

If experiencing infertility, scrotal discomfort (worse at end of day or with activity), or if a varicocele is present, get evaluated as it’s a common cause of infertility and can cause progressive damage to testicular function.

35. Treat Peyronie’s Disease

If experiencing penile curvature or deformity due to Peyronie’s disease, be aware that treatments like collagenase injections, stretching devices, or surgical options are available to correct the issue.

36. Perform Testicular Self-Exams

While national guidelines discourage routine testicular self-exams due to potential anxiety, if you are concerned, perform self-exams and consult a physician if you identify any firm, painless masses or changes in testicular size.

37. Consider Penile Implants for ED

For severe erectile dysfunction, surgical penile implants (non-inflatable or inflatable) are available options to achieve a rigid erection when desired.

38. Consult for Pelvic Floor Therapy

Consult a pelvic floor physical therapist if you have specific needs like prostate cancer rehabilitation or if you have an overly tense pelvic floor, as Kegel exercises are not universally beneficial and can be harmful if misused.

39. Restore Energy with NSDR

Engage in yoga nidra or non-sleep deep rest (NSDR) sessions, even for just 10 minutes, to greatly restore levels of cognitive and physical energy.

40. Consult PCP/Urologist for Testing

Consult your primary care physician or a urologist to explore options for getting male reproductive health tests, such as hormone profiles and sperm analysis, covered by insurance.

41. Advocate for Male Health Coverage

Advocate for increased insurance coverage for male reproductive health testing, as men lack the automatic feedback of menstrual cycles and often need testing to identify potential issues.