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How to Rewire Your Brain & Learn Faster | Dr. Michael Kilgard

Episode 241 Aug 11, 2025 3h 9m 20 insights
In this episode, my guest is Dr. Michael Kilgard, PhD, a professor of neuroscience at the University of Texas at Dallas and a leading expert on neuroplasticity and learning across the lifespan. We discuss the need for alertness, effortful focus, post-learning reflection and sleep to induce neuroplasticity, and how dopamine, acetylcholine, serotonin and norepinephrine are each involved. He explains the behavioral steps for neuroplasticity, as well as vagal nerve stimulation (VNS) and other therapies for tinnitus, stroke, depression, PTSD and paralysis. This episode ought to be of use to anyone interested in understanding the modern science of brain rewiring and learning to improve cognitive or motor skills or treat sensory or motor disorders. Read the episode show notes at hubermanlab.com.
Actionable Insights

1. Drive Brain Plasticity & Meaning

Cultivate neuroplasticity and extract meaning from experiences by combining focused attention, ‘friction’ (effort or challenge), reflection on those experiences, and sufficient sleep for rewiring. This formula helps the brain make lasting changes and find purpose.

2. Prioritize Real-World Experiences

Engage in real-world experiences that offer the full ‘statistics of the natural world’ (e.g., diverse sensory inputs like smell, touch, taste, integrated together) rather than artificial or simplified digital environments. This fosters a brain that can forage for interesting experiences and develop robustly.

3. Practice Active Engagement for Learning

Ensure learning involves active engagement, as this leads to better neuroplasticity and generalization compared to passive observation. Actively interacting with new information or skills helps the brain form stronger, more useful connections.

4. Utilize Self-Testing for Durable Learning

Regularly self-test when learning new information or skills, as this method significantly accelerates learning and makes memories much more durable over time. Self-testing acts as an ‘anti-forgetting’ mechanism, reinforcing what you’ve learned.

5. Allow Time for Reflection & Integration

After significant experiences, lectures, or social interactions, avoid immediate distraction (e.g., by phones) and instead allow time for reflection and mental rehearsal. This period is crucial for the brain to reorganize, reframe, and consolidate learning.

6. Embrace Diversity of Experiences

Seek a wide diversity of experiences, rather than trying to maximize only ‘good’ ones or minimize ‘bad’ ones. Many challenging or unexpected experiences can provide valuable skills and insights that contribute to overall resilience and learning.

7. Engage in Simple, Accomplishable Goals

Actively engage in accomplishing simple, pedestrian goals (e.g., cooking, chores) as this provides satisfaction and counters disengagement, which can otherwise lead to anxiety and depression. Humans are wired to be actively doing something.

8. Be Skeptical of Over-Stimulation

Be cautious of over-stimulating the brain, especially in children, as constant novelty and rapid, disconnected sensory input (e.g., from excessive short-form video content) can potentially lead to negative long-term consequences like increased depression and anxiety, and may hinder focus on real-world tasks.

9. Manage Tinnitus by Avoiding Focus

If you experience tinnitus (ringing in the ears), actively try to ignore it and avoid worrying about it, as paying attention and fretting can self-amplify the underlying neural circuits and exacerbate the condition.

10. Correct Childhood Amblyopia Early

If a child has a ’lazy eye’ (amblyopia) or an eye that doesn’t align correctly, seek pediatric ophthalmologist treatment early. Interventions like patching or eye drops during critical developmental periods can prevent permanent vision issues.

11. Understand Neuromodulator ‘Sweet Spot’

Recognize that for optimal brain function and plasticity, there’s often an ‘inverted U’ principle for neuromodulators: too little or too much can be detrimental, while a ‘sweet spot’ or ‘Goldilocks zone’ enhances function. This applies to both endogenous release and exogenous substances.

12. Evaluate Commercial Brain Devices Critically

Approach non-invasive commercial brain stimulation devices with skepticism, especially if they claim to boost learning or memory without providing specific, useful, and closed-loop information or feedback. Devices that are ‘always on’ or lack sensors are unlikely to provide significant benefit.

13. Consider Vagus Nerve Stimulation (VNS)

For individuals with debilitating conditions like stroke, spinal cord injury, tinnitus, or PTSD, consider vagus nerve stimulation (VNS) as a therapeutic tool. VNS, when paired with targeted physical or cognitive therapy, can trigger neuromodulator release to open a window for enhanced brain plasticity and recovery.

14. Be Informed About Drug Effects

Understand that drugs (e.g., SSRIs, Ritalin) can have off-target effects beyond their intended purpose (e.g., SSRIs affecting bone strength, Ritalin affecting growth). Be aware of both the potential benefits and unintended consequences to make informed decisions.

15. Force Use of Affected Limb Post-Stroke

For stroke recovery, actively avoid over-relying on the healthy limb and instead force the use of the affected limb. This ‘constraint-induced movement therapy’ is crucial for driving plasticity and regaining function in the injured areas.

16. Embrace Complexity in Brain Health

Accept that most neurological and psychiatric disorders are complex, arising from multiple interacting factors (genetics, experiences, diet, stress) rather than a single cause. A multi-pronged approach involving devices, pharmacology, and therapy is often necessary for effective treatment.

17. Maintain Diverse & Balanced Diet

Consume a diverse and balanced diet, as relying on a limited range of foods can lead to nutritional deficiencies and health problems. Metabolic health, supported by good nutrition, is increasingly recognized as influencing mental health.

18. Practice Spaced Repetition for Change

Incorporate spaced repetition into your learning and skill acquisition routines. Significant brain changes require repeated exposure and practice over time, not just a single intense session.

19. Set Environment for Child Practice

For children, create an environment that encourages practice, exploration, and the opportunity to succeed without quitting. This supports their self-directed learning and the development of motor and cognitive skills.

20. Question Consistency, Embrace New Ways

Challenge the idea that consistency is always optimal; be open to new ways of learning, thinking, and doing things, and be willing to admit when you are wrong. This mindset fosters continuous growth and adaptation.