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Essentials: Understanding & Conquering Depression

Jul 3, 2025 40m 43s 11 insights
In this Huberman Lab Essentials episode, I explore major depression, including its underlying biology and discuss science-based approaches to alleviate symptoms and improve mood. I describe the wide-ranging symptoms of depression and explain how key neurotransmitters, hormones, stress, genetics and inflammation contribute to its development and persistence. I also cover treatment options, from traditional classes of antidepressant medications to emerging therapies such as ketamine and psilocybin. Finally, I highlight lifestyle-based tools, including exercise, supplementation and dietary strategies that can help manage depressive symptoms and promote mental well-being. Read the episode show notes at hubermanlab.com.
Actionable Insights

1. Mitigate Stress with Predisposition

Learn to counter stress, especially if you have a genetic predisposition to depression (family history), as stress is identified as a major factor that can trigger depressive episodes.

2. Engage in Regular Therapy

Incorporate regular therapy into your routine, as it provides a good rapport, emotional support, directed guidance, and useful insights, which are considered vital for overall health.

3. Perform Regular Exercise

Engage in consistent physical activity, including aerobic and resistance training, as it is a protective behavior against depression and helps relieve symptoms by increasing norepinephrine, dopamine, and serotonin levels.

4. Increase EPA Omega-3 Intake

Consume more than 1000mg, and ideally closer to 2000mg, of EPA omega-3s daily to limit inflammatory cytokines, which diverts tryptophan towards serotonin production and can benefit mood and offset major depressive disorder.

5. Avoid Overwhelming Pleasure Centers

Consciously avoid overstimulating your pleasure centers through excessive activities or compounds, as this practice can set you up for anhedonia and depression.

6. Take Deliberate Cold Showers

Regularly expose yourself to deliberate cold showers or ice baths, as this releases norepinephrine and epinephrine, which can help alleviate depressive symptoms related to low norepinephrine levels.

7. Get Hormonal Blood Panel

Consult a doctor for a blood panel that includes measurements of thyroid hormone and cortisol hormone, especially if experiencing depression, as hormonal shifts are linked to susceptibility and severity of the condition.

8. Avoid PFAS in Cookware

Choose cookware and other kitchen products that are free of PFASs (forever chemicals), as these toxic compounds are linked to major health issues like hormone disruption, gut microbiome disruption, and fertility problems.

9. Creatine for SSRI Efficacy

If you are a woman with major depressive disorder taking SSRIs, consider creatine monohydrate supplementation, as it can augment or enhance the response to SSRIs, potentially lowering the required dose or improving effectiveness.

10. Ketogenic Diet for Refractory Depression

Explore a ketogenic diet if you have major depressive disorder that is refractory (does not respond) to classical antidepressants, as it may increase GABA and provide some relief for depressive symptoms.

11. Daily AG1 Supplementation

Consider daily intake of AG1, a vitamin, mineral, and probiotic drink, to support overall health, energy, focus, digestive health, immune system health, bowel regularity, and to reduce bloating.