← Huberman Lab

Essentials: The Science of Gratitude & How to Build a Gratitude Practice

Oct 23, 2025 39m 31s 15 insights
In this Huberman Lab Essentials episode, I explore the science of gratitude and how to develop an effective, research-supported gratitude practice. I explain why common gratitude practices (like simply listing things you're grateful for) are far less impactful than engaging in story-based gratitude practices. I also explain how being grateful activates specific brain regions, which enhance calm, social connection and motivation, while reducing anxiety and inflammation. Finally, I share why we can't simply trick our brains into feeling grateful and describe a practical weekly gratitude practice that will improve both your mental and physical well-being. Read the episode show notes at hubermanlab.com.
Actionable Insights

1. Adopt Effective Gratitude Practice

Engage in a gratitude practice 1-3 times per week to achieve long-lasting positive impacts on subjective well-being, mental and physical health, and to shift pro-social neural circuits to dominate your mindset by default.

2. Ground Gratitude in Receiving Thanks

Focus your gratitude practice on the feeling of receiving thanks, either by recalling a personal experience where you genuinely received gratitude or by deeply imagining someone else receiving genuine help and thanks through a powerful story.

3. Prepare a Gratitude Story

Select a personal or observed narrative that genuinely moves you, then write down 3-4 bullet points as cues, including the state before and after receiving gratitude, and any emotionally impactful elements of the story.

4. Practice Gratitude Consistently

After establishing your gratitude story and bullet points, read them to cue your nervous system and then spend 1-5 minutes (even 60 seconds is effective) deeply feeling the genuine experience of receiving or observing gratitude, returning to the same story repeatedly for potency.

5. Reduce Anxiety & Boost Motivation

Regularly performing the effective gratitude practice can shift emotion pathways in your brain, making anxiety and fear circuits less active while increasing circuits for well-being and motivation.

6. Lower Inflammation & Amygdala Activity

Consistent engagement in the described gratitude practice can lead to rapid reductions in amygdala activity (threat detection) and significant decreases in inflammatory cytokines like TNF-alpha and IL-6.

7. Build Trauma Resilience

A regular gratitude practice can buffer against the negative psychological and physiological effects of prior traumatic experiences and inoculate against future traumas.

8. Enhance Social Relationships

Regularly practicing gratitude can improve your social relationships across all domains, including work, school, family, romantic partnerships, and even your relationship with yourself.

9. Avoid Ineffective Gratitude Methods

Do not rely on traditional gratitude practices that involve merely writing down or thinking about a list of things you’re grateful for, as these are not shown to be effective in shifting neural or somatic circuitry.

10. Do Not Fake Gratitude

Avoid lying to yourself or ‘faking it until you make it’ when it comes to gratitude, as your brain can discern insincerity, preventing the positive health effects.

11. Give Gratitude Wholeheartedly

When expressing gratitude to others, ensure your thanks are genuine and wholehearted, as reluctant or insincere expressions undermine the positive impact for the receiver.

12. Regulate Sleep Temperature

Optimize your sleeping environment’s temperature, as your body temperature needs to drop 1-3 degrees to fall and stay deeply asleep, and increase 1-3 degrees to wake refreshed.

13. Utilize NSDR for Sleep & Recovery

Incorporate Non-Sleep Deep Rest (NSDR) scripts to offset negative effects of slight sleep deprivation, improve falling back asleep if you wake up, and support overall relaxation and recovery.

14. Take AGZ for Enhanced Sleep

Consider taking AGZ, a comprehensive sleep supplement, 30-60 minutes before sleep to improve the quality and depth of your sleep.

15. Avoid PFAS in Cookware

Steer clear of cookware containing PFAS (forever chemicals) like Teflon, as these toxic compounds are linked to major health issues including hormone disruption, gut microbiome disruption, and fertility problems.