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Essentials: How to Optimize Testosterone & Estrogen

Feb 20, 2025 37m 2s 23 insights
In this Huberman Lab Essentials episode, I explain how to optimize hormones—particularly testosterone, estrogen, and related sex steroids—to enhance fertility and overall well-being. I discuss the sources of testosterone and estrogen and how their levels fluctuate with age in both males and females. I also cover how behaviors such as exercise, cold and heat exposure, light exposure, illness, and breathing patterns affect hormones. Additionally, I examine specific supplements and replacement therapies, highlighting important precautions to consider when adjusting hormone levels. Read the show notes for this episode at hubermanlab.com. Huberman Lab Essentials are short episodes focused on essential science and protocol takeaways from past full-length Huberman Lab episodes. Watch or listen to the full-length episode at ⁠⁠⁠⁠⁠⁠⁠hubermanlab.com⁠⁠⁠⁠⁠⁠⁠.
Actionable Insights

1. Morning Light Exposure

View bright light (ideally sunlight, 2-10 minutes) within the first hour of waking, without sunglasses, to properly time cortisol release, increase dopamine, and promote healthy testosterone and estrogen production.

2. Avoid Nighttime Bright Light

Avoid bright light exposure to your eyes in the middle of the night, as it suppresses dopamine release and consequently suppresses testosterone levels, impacting sex steroid hormone optimization.

3. Prioritize Nasal Breathing

Practice nasal breathing during waking hours and sleep, as it increases oxygen intake, offloads carbon dioxide, improves sleep, reduces apnea, and indirectly optimizes testosterone and estrogen by reducing cortisol.

4. Optimize Sleep Temperature

Control your sleeping environment’s temperature to optimize sleep quality, as your body temperature needs to drop 1-3 degrees to fall and stay deeply asleep, and increase 1-3 degrees to wake up refreshed. Program your mattress cover’s temperature for the beginning, middle, and end of the night for best results.

5. Address Sleep Apnea

If you suffer from severe sleep apnea, consider using a CPAP machine to ensure proper breathing and sleep, as apnea is associated with poor estrogen and lower testosterone levels.

6. Nasal Breathe During Exercise

Engage in nasal breathing during cardiovascular exercise, unless at maximum effort, to dilate sinuses over time, improve breathing efficiency, and indirectly support hormone optimization.

7. Engage in Heavy Weight Training

Perform heavy weight training, in the 1-8 repetition range (not to failure), to significantly increase testosterone levels for 24-48 hours in both males and females.

8. Order Exercise for Hormones

If combining weight training and cardiovascular exercise in the same session, perform heavy weight training first, followed by endurance activity, to optimize testosterone levels.

9. Perform High-Intensity Interval Training

Incorporate high-intensity interval training (HIIT) or sprinting into your routine, as this type of exercise is shown to increase testosterone levels.

10. Limit Prolonged Endurance Exercise

Avoid endurance exercise sessions that extend beyond 75 minutes, as prolonged activity can lead to reductions in testosterone, likely due to increased cortisol.

11. Engage in Competition

Participate in competitive scenarios, even short-lived ones, as competition itself can increase androgens like testosterone, independent of winning or losing, by liberating testosterone from the adrenals.

12. Utilize Cold Exposure

Engage in cold exposure, such as ice baths or cold showers, to potentially stimulate sex steroid hormones by causing vasoconstriction followed by a rebound vasodilation, increasing blood flow to the gonads.

13. Supplement Key Nutrients

Supplement with essential nutrients like Vitamin D, Zinc, and Magnesium, as these are useful for promoting testosterone and estrogen production in their proper ratios.

14. Monitor Hormones with Blood Work

Before and during any modification of sex steroid hormones or supplementation, get regular blood work done to ensure safety, monitor effectiveness, and understand the levels of hormones like testosterone, estrogen, DHT, aromatase, and LH.

15. Monitor Menstrual Cycles

For ovulating females, monitor menstrual cycles to understand the exquisite balance of hormones like LH, FSH, and progesterone, especially when considering hormone modulation.

16. Avoid Excessive Opioid Use

Avoid excessive opioid use, as opioids dramatically reduce levels of testosterone and estrogen by disrupting receptors on gonadotropin-releasing hormone neurons, leading to endocrine syndromes.

17. Consider Tongkat Ali Supplementation

Consider supplementing with Tongkat Ali (Eurycoma longifolia Jack) at 400-800mg/day, as studies suggest it may promote fertility, increase free testosterone, act as a subtle aphrodisiac, and have a slight anti-estrogen effect.

18. Consider Fadogia Agrestis Supplementation

Explore supplementing with Fadogia Agrestis, as literature suggests it can increase luteinizing hormone levels, which in turn may increase testosterone or estrogen levels.

19. Consider Menopause Hormone Therapy

For menopause symptoms, consult a physician about supplemental estrogen therapy (oral, patch, or pellet), which can secrete estradiol into the system, though success and side effects vary by individual.

20. Utilize Comprehensive Blood Testing

Use comprehensive blood testing services like Function Health to get a snapshot of over 100 biomarkers, including hormone health, and receive insights from expert doctors to understand and improve your health.

21. Consider AG1 Supplementation

Consider taking AG1 daily, a vitamin, mineral, probiotic drink with prebiotics and adaptogens, as it’s suggested to improve overall mental and physical health and performance.

22. Utilize 8Sleep Mattress Cover

Use an 8Sleep smart mattress cover to control your sleeping environment’s temperature, which is critical for falling and staying deeply asleep and waking up refreshed, thereby improving sleep quality.

23. Consider Parental Impact on Hormones

Be aware that becoming a parent is associated with a significant decrease in testosterone levels (almost 50% in expecting fathers) and an increase in prolactin and estradiol, which can reduce the desire for sex.