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Essentials: How to Control Your Sense of Pain & Pleasure

Jun 19, 2025 37m 28s 6 insights
In this Huberman Lab Essentials episode, I explore the sensations of pain and pleasure, explaining how they are sensed in the body and interpreted by the brain as well as methods to control their intensity. I discuss both the hardwired mechanisms and subjective factors that shape an individual’s perception of pain and pleasure. I also explain why pain thresholds vary from person to person and discuss various treatments for pain management such as acupuncture and supplements. Finally, I explain the role of key neurochemicals like dopamine and serotonin in mediating our experience of pain and pleasure. Read the episode show notes at hubermanlab.com.
Actionable Insights

1. Avoid Excessive Dopamine Peaks

Be cautious of experiences (chemical, physical, emotional) that cause excessively high, chemically-induced dopamine peaks, as repeated exposure can lead to habituation, reduced pleasure response, and increased pain perception, forming the basis of addiction.

2. Optimal Pain Preparation Window

If a painful stimulus is anticipated, prepare mentally for it between 20 and 40 seconds beforehand to reduce the subjective experience of pain. Warning too soon (2 seconds) or too late (2 minutes) can worsen the experience.

3. Enter Cold Water Quickly

When entering cold water (e.g., an ice bath), do so quickly and up to your neck, as this is neurobiologically more comfortable than entering slowly or partially, due to how cold-sensing neurons respond to relative temperature drops.

4. Approach Heat Gradually

When exposing yourself to heat, gradually move into it to find a safe and comfortable threshold, as heat is measured in absolute terms by neurons, unlike cold.

5. Acetyl L-Carnitine for Pain

Consider taking Acetyl L-carnitine orally at dosages of 1 to 3, and sometimes 4, grams per day to potentially reduce symptoms of chronic whole-body pain and certain forms of acute pain.

6. Electroacupuncture for Pain Relief

Explore electroacupuncture of the legs and feet, as it can activate neural circuits leading to the release of anti-inflammatory catecholamines, potentially reducing pain symptoms and accelerating wound healing.