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Essentials: How to Build Endurance

Apr 17, 2025 44m 12s 11 insights
In this Huberman Lab Essentials episode, I explain how to build endurance and describe targeted protocols to enhance different types of endurance. I discuss how endurance—the ability to sustain effort—requires the coordination of physical and mental systems driven by energy availability, brain willpower, and specific training adaptations in the muscles, heart, lungs and neurons. I explain conditioning protocols designed to enhance four types of endurance, from long-duration steady state to muscular endurance and high-intensity intervals, and how each training style triggers unique adaptations in the body and brain, such as improved mitochondrial function and oxygen utilization. Additionally, I highlight the crucial role of hydration and electrolytes, which are essential for neural function and influence the brain’s willpower to sustain effort. Read the episode show notes at hubermanlab.com. Huberman Lab Essentials are short episodes focused on essential science and protocol takeaways from past full-length Huberman Lab episodes. Watch or listen to the full-length episode at ⁠⁠⁠⁠⁠hubermanlab.com⁠⁠⁠⁠⁠.
Actionable Insights

1. Strengthen Heart Stroke Volume

Engage in high-intensity training where your heart beats very hard (e.g., 1:1 ratio mile repeats). The increased blood return to the heart causes an eccentric loading of the cardiac muscle, making the heart stronger and able to pump more blood per beat, which improves fuel delivery to muscles and brain, enhancing cognitive function.

2. Implement High-Intensity Aerobic Conditioning

Engage in 3-12 sets of work with a 1:1 work-to-rest ratio (e.g., run a mile, then rest for the same duration it took to run). Focus on performing 8-12 minutes of work per set, 2-3 times a week, to improve ATP and mitochondrial function, enhance oxygen delivery to muscles and brain, increase heart stroke volume, and build lung capacity.

3. Practice High-Intensity Anaerobic Endurance

Perform 3-12 sets with a work-to-rest ratio of 3:1 to 1:5 (e.g., 30 seconds on/10 seconds off, or 20 seconds on/100 seconds off), up to twice a week. This training pushes the system above VO2 max, maximizing oxygen utilization, increasing mitochondrial respiration, and training neurons to access more energy, with benefits for competitive and team sports.

4. Build Muscular Endurance

Perform 3-5 sets of 12-100 repetitions (12-25 reps for most) with 30-180 seconds of rest between sets. Focus on mainly concentric movements with light and relatively fast eccentric portions, avoiding deliberate slowing or heavy lowering phases, or use isometric holds like planks and wall sits, to build local mitochondrial oxygen utilization and neuron control over muscles.

5. Engage in Long-Duration Endurance

Perform continuous, steady effort for 12 minutes to several hours (e.g., a 30-minute run) to build mitochondrial density, improve movement efficiency, and increase capillary beds within muscles, enhancing oxygen delivery and overall energy creation.

6. Maintain Optimal Hydration & Electrolytes

Prevent 1-4% body weight loss in water during exercise, as this can reduce work capacity by 20-30% and significantly impair mental operations. Ensure adequate intake of potassium, sodium, and magnesium to support hydration and prevent electrolyte imbalance.

7. Use Galpin Equation for Exercise Hydration

Calculate your hydration needs during exercise by dividing your body weight in pounds by 30 to determine how many ounces of water to drink every 15 minutes of exercise. Adjust intake based on sweating and existing hydration levels.

8. Support Neural Function

Ensure sufficient intake of sodium, potassium, magnesium, and glucose (carbohydrates) to power neurons, which are critical for persistence and preventing quitting during effort.

9. Enhance Brain Function

High-intensity endurance training increases vasculature and capillary beds within the brain, particularly in areas supporting memory (hippocampus), respiration, focus, and effort, leading to improved cognitive functioning.

10. Consider Caffeine for Performance

Use caffeine as a stimulant to improve endurance work and power output across various forms of endurance training.

11. Use Magnesium Malate for Soreness

Consider supplementing with magnesium malate to reduce delayed onset muscle soreness (DOMS), noting it is distinctly different from magnesium forms used for sleep.