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Essentials: Erasing Fears & Traumas Using Modern Neuroscience

Nov 6, 2025 39m 45s 13 insights
In this Huberman Lab Essentials episode, I explore the neuroscience of fear and trauma and how to effectively process and eliminate traumatic responses. I explain why successful fear treatment requires both extinction of the old fearful response and replacement with a new positive association—not just cognitive reframing. I also explain how the threat reflex activates specific circuits connecting the amygdala, prefrontal cortex, and dopamine systems, and why detailed recounting of traumatic events progressively reduces their physiological impact. Finally, I review evidence-based approaches, including prolonged exposure therapy and cognitive behavioral therapy, discuss how five minutes per day of deliberate stress through cyclic hyperventilation can rewire fear responses, explain the critical role of social connection in activating neural pathways that reduce trauma, and share supplementation options for managing anxiety. Read the episode show notes at hubermanlab.com.
Actionable Insights

1. Replace Fear with Positive Events

Understand that fears cannot simply be eliminated; they must be replaced with new, positive events or associations to be unlearned or extinguished.

2. Engage in Behavioral Trauma Therapies

Seek out licensed clinicians for prolonged exposure therapy, cognitive processing therapy (CPT), or cognitive behavioral therapy (CBT) to reduce fears and traumas. This involves repeatedly recounting the traumatic event in detail to diminish physiological responses, and then relearning a new, positive narrative.

3. Control Fear with Narrative

Leverage your prefrontal cortex to attach narrative, meaning, and purpose to fear responses. This allows you to control or suppress reflexive fear by deciding whether to persist, pause, or retreat from a situation.

4. Practice Cyclic Hyperventilation Protocol

(With caution, ideally clinician-supported, not for anxiety/panic disorders) Perform cyclic hyperventilation for 5 minutes daily (deep inhale through nose, exhale through mouth, then every 25-30 breaths, full exhale and hold breath for 25-60 seconds, lungs empty) to deliberately induce a brief, stressful physiological state, potentially while recounting a traumatic event, to recalibrate the fear system.

5. Cultivate Trusting Social Connections

Establish and maintain regular, trusting social connections to significantly benefit the process of working through fear and trauma. This positively impacts the associated chemical systems and neural circuits.

6. Distinguish Protective from Dangerous Fears

Evaluate your fearful memories to identify whether they are protective (preventing harm) or dangerous (maladaptively limiting behavior). This understanding is crucial for deciding which fears to address and how.

7. Get Comprehensive Health Lab Testing

Utilize comprehensive lab testing services, such as Function Health, to obtain a detailed snapshot of your bodily health (e.g., heart, hormones, immune function, nutrient levels). This provides expert insights for improving your physical and mental well-being.

8. Prioritize Foundational Health Habits

Ensure consistent quality nutrition and ample, regular quality sleep as foundational elements to support overall mental and physical health. This indirectly aids in managing fear and trauma.

9. Enhance Sleep with Targeted Supplements

To improve sleep quality and depth, and wake up refreshed, consider taking supplements like magnesium threonate, theanine, chamomile extract, glycine, saffron, or valerian root, or a comprehensive blend like AGZ, 30-60 minutes before sleep.

10. Ensure Optimal Electrolyte Hydration

Drink electrolyte mixes like Element (containing sodium, magnesium, potassium, no sugar) by dissolving one packet in 16-32 ounces of water first thing in the morning and during physical exercise, especially on hot days. This maintains proper hydration and electrolyte balance for optimal brain and body function.

11. Supplement Saffron for Anxiety Reduction

Orally ingest 30 milligrams of saffron daily to reliably reduce anxiety symptoms, based on multiple clinical studies in human subjects.

12. Use Inositol for Anxiety Decrease

Take 18 grams of inositol daily for at least a month to achieve a notable decrease in anxiety symptoms, comparable to prescription antidepressants. However, avoid taking it immediately before or during sessions aimed at amplifying fearful experiences.

13. Explore Ketamine/MDMA Psychotherapy

For severe trauma, consider ketamine-assisted or MDMA-assisted psychotherapy under clinical supervision. These treatments can help diminish the intensity of old traumatic experiences and facilitate the rapid relearning of new, positive narratives and associations.