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Controlling Your Dopamine For Motivation, Focus & Satisfaction

Episode 39 Sep 27, 2021 2h 13m 30 insights
This episode serves as a sort of “Dopamine Masterclass”. I discuss the immensely powerful chemical that we all make in our brain and body: dopamine. I describe what it does and the neural circuits involved. I explain dopamine peaks and baselines, and the cell biology of dopamine depletion. I include 14 tools for how to control your dopamine release for sake of motivation, focus, avoiding and combating addiction and depression, and I explain why dopamine stacking with chemicals and behaviors inevitably leads to states of underwhelm and poor performance. I explain how to achieve sustained increases in baseline dopamine, compounds that injure and protect dopamine neurons including caffeine from specific sources. I describe non-prescription supplements for increasing dopamine—both their benefits and risks—and synergy of pro-dopamine supplements with those that increase acetylcholine.  Read the full show notes for this episode at hubermanlab.com.
Actionable Insights

1. Attach Dopamine to Effort/Friction

Cultivate a growth mindset by consciously associating dopamine release and pleasure with the effort and friction of challenging activities, rather than solely focusing on the end goal or external rewards. This is the most powerful aspect of dopamine for sustained motivation and energy.

2. Implement Intermittent Dopamine Schedules

Apply intermittent reward schedules to activities you want to maintain motivation for by varying the amount of dopamine experienced with each engagement, rather than always chasing maximum dopamine release. This prevents your baseline dopamine from dropping and ensures continued enjoyment.

3. Replenish Dopamine with Fasting

If experiencing a drop in baseline dopamine due to overindulgence in dopamine-evoking behaviors or substances, engage in a ‘dopamine fast’ by limiting or stopping interaction with those triggers. This allows the dopamine system to replenish its readily releasable pool, restoring motivation and mood.

4. Avoid External Post-Activity Rewards

Do not rely on external rewards (e.g., a treat after exercise) to motivate engagement in activities you want to enjoy, as this undermines the intrinsic dopamine release from the activity itself. This practice makes the activity less pleasurable and makes you less likely to lean into hard work in the future.

5. Limit Layering Dopamine Sources

Avoid combining multiple dopamine-spiking substances (e.g., pre-workout drinks) and activities (e.g., listening to music during exercise) too frequently. Layering too many dopamine-evoking elements can lead to severe drops in motivation and energy afterward, progressively lowering your baseline dopamine.

6. Sustain Dopamine with Cold Exposure

Engage in cold water exposure (e.g., 14 degrees Celsius for up to an hour, or 40-60 degrees Fahrenheit for shorter durations) to trigger immediate norepinephrine release and a sustained dopamine increase (up to 250% above baseline for up to three hours). Do this early in the day and with caution to avoid hypothermia, as it promotes an alert yet calm state of mind and improved well-being.

7. Prioritize Quality Social Connections

Actively pursue and engage in quality, healthy social interactions (romantic, familial, friendships) that evoke oxytocin release. Oxytocin release directly stimulates dopamine pathways, which is central to stimulating seeking behaviors for social connection and overall well-being.

8. Avoid Chronic Stimulant Use

Do not use stimulants (e.g., pre-workouts, study drugs) every time you engage in activities you wish to enjoy and stay motivated for. Chronic use will deplete your dopamine, undermining your long-term motivation, focus, and drive.

9. Limit Non-Clinical Stimulant Use

Limit non-prescription use of stimulants like Adderall or Ritalin, as they cause dopamine spikes comparable to illicit drugs and may block neuroplasticity. This undermines long-term motivation and focus unless there is a valid clinical need for their use.

10. Remove Phone from Workouts

Remove your phone and its associated dopamine-spiking activities (music, texting, social media) from your workouts. This prevents layering dopamine sources, which can lead to a loss of interest and reduced pleasure in the activity itself by dropping your dopamine baseline.

11. Randomize Dopamine-Enhancing Aids

Use a random method, like flipping a coin, to decide whether to include dopamine-supportive elements (e.g., music during a workout) in an activity. This prevents over-reliance on external motivators and helps maintain long-term enjoyment and motivation by creating an intermittent reward schedule.

12. Cultivate Appreciation for Activities

Journal or practice appreciation for specific aspects of activities you engage in, especially those you might initially dislike. This practice can increase the intrinsic dopamine evoked by that behavior over time, making it more pleasurable.

13. Reframe Fasting as Reward

Engage in intermittent fasting or deliberate food restriction and consciously attach dopamine release to the deprivation, strain, and effort of fasting itself, rather than solely to the food reward. This enhances mental clarity and reinforces the behavior by leveraging the forebrain to shape primitive circuits.

14. Reinforce Positive Beliefs

Actively seek out information or engage in internal dialogue that reinforces your positive beliefs about beneficial behaviors (e.g., ‘fasting is good for me’). Hearing or thinking things that validate prior beliefs can evoke dopamine release, strengthening those behaviors at a chemical level.

15. Reduce Highly Palatable Foods

Reduce consumption of highly palatable, processed foods for a short period (e.g., two days) to reset your dopamine system. This allows whole, unprocessed foods to taste more appealing and rewarding, as dopamine establishes value based on prior experiences.

16. Moderate Pornography Consumption

Moderate or reduce consumption of pornography, especially intense forms, as it evokes high dopamine release that can make it harder to achieve similar levels of pleasure and satisfaction from real-world romantic and sexual interactions. This is due to the peak-baseline relationship of dopamine.

17. Avoid Amphetamine/Cocaine

Strictly avoid amphetamine and cocaine, as they cause severe dopamine spikes and subsequent baseline drops. These drugs can also limit the brain’s ability to learn and undergo neuroplasticity for extended periods, causing long-term problems with dopaminergic pathways.

18. Use Caffeine to Upregulate Receptors

Consume caffeine (e.g., coffee, tea, yerba mate) as it can increase the density and efficacy of dopamine receptors. This makes whatever dopamine is released by an activity more accessible and functional, unlike other stimulants that deplete dopamine.

19. Consider Yerba Mate for Caffeine

If consuming caffeine, consider yerba mate as your principal source. It contains caffeine, is high in antioxidants, helps manage blood sugar, and has been shown to be neuroprotective specifically for dopaminergic neurons in some studies.

20. Avoid Caffeine with MDMA

Do not consume caffeine when using MDMA, as caffeine increases the density and efficacy of dopamine receptors. This upregulation can lead to increased toxicity of MDMA, making it a potentially dangerous combination.

21. Avoid Melatonin for Sleep

Avoid using exogenous melatonin for sleep, as it can help one get to sleep but not stay asleep, and has been shown to significantly decrease dopamine levels 60 minutes after administration. Dimming lights at night is a better alternative for maintaining healthy dopamine levels.

22. Dim Lights at Night

Dim lights between 10 p.m. and 4 a.m. to avoid bright light exposure. Viewing bright lights during these hours has been shown to reduce dopamine levels for several days afterward.

23. Exercise Caution with Mucuna Pruriens

Exercise extreme caution with Mucuna Pruriens (L-dopa precursor), as it causes very large, intense, but transient dopamine increases. This is almost inevitably followed by a crash and reduction in baseline dopamine, similar to other potent dopamine-increasing compounds.

24. Use L-Tyrosine Intermittently

If using L-tyrosine (500-1000mg) for focus and motivation, do so intermittently (e.g., once or twice a week). This helps avoid the inevitable crash and reduction in baseline dopamine that follows its transient increase.

25. Consider PEA + Alpha GPC

For intense mental work, consider taking 500mg of PEA (phenylethylamine) and 300mg of Alpha GPC intermittently (e.g., once every one to two weeks). This combination can lead to a sharp but very transient increase in dopamine, which some find more regulated than L-tyrosine.

26. Explore Huperzine A

Explore Huperzine A as a nootropic, as it can increase acetylcholine transmission and dopamine in the medial prefrontal cortex and hippocampus. This may aid learning, memory, and focus by stimulating both cholinergic and dopaminergic circuits.

27. Supplement with Athletic Greens

Take Athletic Greens once or twice a day to cover basic nutritional needs, address potential deficiencies, and support microbiome health with probiotics. This comprehensive supplement contributes to overall well-being, which indirectly supports dopamine system health.

28. Supplement Vitamin D3 K2

Supplement with Vitamin D3, which is essential for various aspects of brain and body health and often deficient even with sun exposure, and K2, important for cardiovascular function and calcium regulation. These vitamins support overall physiological health, contributing to a stable internal environment for dopamine.

29. Ensure Electrolyte Hydration

Dissolve one packet of Element in 16-32 ounces of water first thing in the morning and during physical exercise to ensure proper hydration and adequate electrolytes (sodium, magnesium, potassium). Proper hydration and electrolytes are critical for optimal brain and body function, including neuronal activity.

30. Practice NSDR/Yoga Nidra

Use meditation apps like Waking Up to practice Yoga Nidra or Non-Sleep Deep Rest (NSDR) sessions, even for just 10 minutes. These protocols can greatly restore levels of cognitive and physical energy, contributing to overall mental and physical well-being.