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Why Women Are More Likely to Develop Alzheimer’s with Dr Lisa Mosconi #129

Oct 28, 2020 1h 52m 25 insights
Women's brain health remains one of the most under researched, under diagnosed and under undertreated fields of medicine. Women are twice as likely as men to develop Alzheimer’s and twice as likely to become anxious or depressed. They are four times more likely to suffer with headaches and migraines and they are more prone to brain tumours and strokes than men. Today’s guest says this is a clear indication of functional differences between female and male brains. And she’s made it her life’s work to learn more about it. Neuroscientist Dr Lisa Mosconi is director of the Women’s Brain Initiative and works at the Alzheimer’s Prevention Clinic at Weill Cornell Medical College, US, where she studies how genetics, lifestyle and nutrition shape brain health, particularly in women. Lisa describes her frustration at constantly being told by peers that the reason Alzheimer’s was more prevalent in women was simply because they live longer, and it’s a disease of ageing. We discuss her ground-breaking research that has exposed this bias, finding dementia brain changes can actually begin in midlife, triggered by declining oestrogen during perimenopause. Worrying as that might sound, this discovery will enable women to take control of their risk at a much earlier age. Lisa goes on to share plenty of practical, evidence-based advice to help you do that. I was really moved hearing Lisa talk about the beautiful changes that happen in the female brain during pregnancy and post-partum. It’s a new take on the idea of ‘Mummy brain’ and will be validating for all mothers out there to hear. She also gives a clear and candid explanation of how perimenopause alters brain function. So many of my patients in their 40s and 50s are scared by changes like forgetfulness, brain fog and anxiety. If that’s you or someone you know, Lisa’s insights and advice will be really empowering. I’m a passionate advocate for women’s health equality. Yet chatting with Lisa made me realise how much more work we all have to do to get topics like these out there and understood. This conversation is relevant to all of us, women and men alike. I hope it gets you thinking and talking more.  Show notes available at drchatterjee.com/129 Follow me on instagram.com/drchatterjee/ Follow me on facebook.com/DrChatterjee/ Follow me on twitter.com/drchatterjeeuk
Actionable Insights

1. Start Dementia Prevention in Midlife

Begin taking preemptive and preventive actions for dementia in your 30s, 40s, and 50s, as the disease can start decades before symptoms appear, offering a crucial window for intervention.

2. Prioritize Lifestyle & Medical Brain Health

Understand that while genetics play a role, your lifestyle and overall medical health are equally important for brain health and can significantly influence your risk of conditions like Alzheimer’s.

3. Nurture Whole Body for Brain Health

Recognize that the brain is not an isolated organ; everything happening in your body affects your brain, so by taking care of your body, you simultaneously support your brain, cognition, mood, and sleep.

4. Manage Stress for Hormones & Brain

Actively implement strategies to reduce and manage chronic stress, as high cortisol levels can steal precursors from sex hormones, exacerbating symptoms and negatively impacting brain health, particularly for women in midlife.

5. Mandatory Scheduled Self-Care

Proactively schedule and block out dedicated time in your calendar for stress-reducing activities, such as an hour of daily exercise and 20 minutes of meditation, making self-care a mandatory part of your weekly routine to ensure it happens.

6. Midlife Fitness Lowers Dementia Risk

Prioritize and maintain physical fitness in midlife (e.g., through regular exercise) to achieve a 30% lower risk of dementia later in life compared to being sedentary.

7. Women: Moderate Exercise for Brain Health

Women, particularly from perimenopause onward, should aim for low to moderate intensity exercise, as this range yields maximum brain health benefits, with very high intensity potentially reducing gains.

8. Adopt a Mediterranean-Style Diet

Commit to a Mediterranean-style diet, as research shows that a 50-year-old woman on this diet can have a brain that appears at least five years younger compared to those on a Western diet, preventing brain shrinkage.

9. Embrace Plant-Centric Diet with Flax Oil

Build your diet around plants, including vegetables, fruits, grains, and legumes, and use unrefined oils like extra virgin olive oil and flax oil; for vegans, incorporate one tablespoon of flax oil daily to ensure adequate omega-3 intake for brain health.

10. Eat Lignan-Rich Phytoestrogen Foods

Boost your intake of lignan-rich foods such as sesame seeds, flax seeds, dried apricots, chickpeas, beans, strawberries, melon, and cantaloupe, as these are safe sources of phytoestrogens linked to a lower risk of various health issues in women.

11. Prioritize Strict Bedtime for Sleep

Make sleep a top priority by establishing and adhering to a strict bedtime, such as being asleep by 10 PM, to ensure you get sufficient rest, particularly if you wake early for work.

12. Consistent Brain Care for Lifelong Health

Develop discipline and consistency in applying brain-healthy strategies throughout your life, especially in midlife, as this commitment is the best predictor of your long-term health and well-being.

13. Prioritize Reproductive Organ Brain Health

Understand that there’s constant communication between the brain and reproductive organs, making the health of these organs crucial for overall brain health in both men and women.

14. Practice Yoga & Meditation Consistently

Incorporate consistent yoga and meditation practices into your routine, as clinical studies show they can beneficially impact brain health and functionality, even for those initially skeptical.

15. Regular 11-Minute Kirtan Kriya Meditation

Regularly practice the 11-minute Kirtan Kriya meditation, a Kundalini yoga technique, as it is scientifically proven to improve blood flow to the brain, reduce cortisol levels, and enhance memory function, particularly for women in midlife and after.

Do not blindly follow health trends; instead, choose timeless, traditional, and scientifically-backed approaches, particularly for diet and exercise, that have been proven effective over generations.

17. Embrace Simple, Sufficient Physical Activity

Incorporate simple physical activities like taking the stairs or walking a bit faster into your daily routine, recognizing that these are beneficial for your brain, and be proud of doing enough for your body without feeling guilty if you can’t do more.

18. Prioritize Enjoyable, Consistent Self-Care

Shift your focus from unrealistic expectations to finding enjoyable forms of exercise and self-care that you can consistently integrate into your life, doing things out of pleasure rather than just duty.

19. Educate Children Early on Nutrition

Provide children with early education about nutrition, teaching them which foods benefit their brain, mood, and sleep, and how to view less healthy options as occasional treats.

20. Consistent Bedtime Meditation for Kids

Establish a consistent bedtime meditation routine with children, using kid-friendly apps or stories, to help them fall asleep easily, sleep through the night, and develop a language of self-appreciation and kindness.

21. Model Active Behavior for Women/Kids

Actively model physical activity for women and children, particularly to counteract the decline in exercise often seen after college, as this raises awareness and encourages healthier habits.

22. Demand Accurate Women’s Health Information

Actively demand accurate and comprehensive information regarding women’s body and brain health to accelerate the development of effective and tailored medical solutions.

23. Practice Compassion and Active Listening

Offer compassion and actively listen to understand others’ experiences, particularly women’s health concerns like menopausal symptoms, as feeling heard is a crucial first step in providing help.

24. Choose High-Quality Soy Sources

If incorporating soy for its phytoestrogen content, prioritize non-GMO and unpolluted sources, as conventionally processed soy in industrialized countries may differ in quality and allergenic potential compared to traditional Asian diets.

25. Diverse Diet: Fish, Occasional Meat/Dairy

Follow a flexible, diverse diet that includes fish as a regular component, while treating meat and dairy products as occasional treats, avoiding deprivation or extreme food restriction.