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The New Science of Living a Longer and Healthier Life with Professor Rose Anne Kenny (Re-release) #619

Feb 1, 2026 2h 17m 67 insights
Longevity is a hot topic these days. We’re obsessed with anti-ageing, as if getting older should be avoided or even reversed at all costs! Of course, we can’t do that and I’m not sure we’d really want to. But today’s guest brings valuable insights about what we can do, to make sure we age healthily and happily.    Professor Rose Anne Kenny is a medical gerontologist and Regius Professor of Physic and Chair of Medical Gerontology at Trinity College Dublin. She’s the Founding Principal Investigator of Ireland’s largest population study of ageing (TILDA) and the author of the international bestseller Age Proof: The New Science of Living a Longer and Healthier Life.  In this conversation, Professor Kenny reveals that while 20 percent of ageing is genetic and can’t be changed, 80 percent is epigenetic – in other words, we have the power to influence how quickly or how slowly we age. Her number one recommendation is having good quality friendships and relationships throughout our lives. Then follows a healthy diet, plenty of exercise, and reducing stress. So nothing too surprising, perhaps. But what might surprise you is just how far reaching the effects of these relatively simple measures can be – and how much what you do in your 20s can impact your 80s. We talk about how to avoid metabolic syndrome and why it’s important to know key biological markers throughout life. We take a deep dive into the benefits of community, family, volunteering and inter-generational friendships, and discuss the undercurrent of ageism that prevails in society. Loneliness increased threefold during the pandemic, according to the TILDA study, and it’s left some people feeling afraid to reconnect. Yet isolation is known to cause inflammation, suppress immunity and speed ageing. Professor Kenny believes we should flip convenience on its head when it comes to exercise. Instead of taking the easy option that means moving less, we should look at the ‘harder’ options, such as taking the stairs or carrying heavy bags, as convenient ways to build activity and strength training into our lives. She also shares excellent advice on sex and intimacy, sleeping better, laughing more, and finding purpose all around you. This really is a wonderful and practical conversation that is going to give you a variety of simple ways to play the long game when it comes to ageing. And the empowering message is that it’s never too early and it’s never too late to start.    Support the podcast and enjoy Ad-Free episodes. Try FREE for 7 days on Apple Podcasts https://apple.co/feelbetterlivemore. For other podcast platforms go to https://fblm.supercast.com.   Thanks to our
Actionable Insights

1. Control Your Aging Process

Understand that 80% of the aging process is within your control, meaning lifestyle choices significantly impact how quickly or slowly you age.

2. Prioritize Social Connections

Elevate social connections, friendships, and engagement to the highest priority for healthy aging, as their profound positive impact is intuitive and scientifically supported.

3. Cultivate Positive Aging Attitude

Understand that your attitude towards life and aging is hugely important, potentially the most critical factor, and consciously work to create a positive perspective.

4. Reduce Systemic Inflammation

Prioritize strategies to reduce inflammation, as it is identified as a primary factor that accelerates the aging process and is causal for many biological changes.

5. Multi-Intervention for Biological Age Reversal

Implement a multi-faceted lifestyle intervention including a microbiome-focused diet, 30 minutes of 60-80% maximal exercise five days a week, daily breathing exercises, and sleep improvement measures, as this can reduce biological aging by years in just eight weeks.

6. Adopt a Healthy Diet

Follow a healthy diet as it is a crucial factor in influencing the aging process and overall well-being.

7. Prioritize Plenty of Exercise

Ensure you get plenty of exercise, as it is a very important factor that makes a difference in the aging process.

8. Reduce Stress Levels

Actively work to attenuate stress processes and stress itself, as stress is detrimental for us and impacts the aging process.

9. Cultivate Daily Purpose

Actively cultivate a sense of purpose in your daily life, understanding that anything can have purpose, as feeling purposeful is physiologically beneficial and prevents negative health outcomes.

10. Prioritize Daily Laughter

Actively seek out opportunities for laughter daily, as it releases beneficial neurohormones and has significant health benefits, including a 48% reduction in heart attack recurrence risk.

11. Start Healthy Aging Anytime

Understand that it’s never too early and never too late to start implementing strategies to play the long game when it comes to healthy aging.

12. Consistent Long-Term Healthy Habits

Recognize that healthy aging is a long game that requires consistency in your beneficial habits, with greater impact if you start early.

13. Monitor Key Biological Markers Annually

After age 40, know your seated and standing blood pressure, full lipid profile, and hemoglobin A1c (HbA1c) every year, as these are accessible and crucial indicators of health.

14. Address High-Normal HbA1c

If your HbA1c is in the high-normal range, take action immediately with lifestyle modifications such as reducing sugar, managing diet, and losing weight, as it’s reversible and likely to progress otherwise.

15. Integrate Strength Training

Incorporate strength training into your routine, understanding it’s predominantly about keeping muscles moving and can be achieved through purposeful daily activities, not just formal gym weights.

16. Prevent Sarcopenia: Keep Moving

Prevent sarcopenia and frailty by continuously keeping your muscles moving and functioning, as they need to be reminded to stay active as you get older.

17. Integrate Movement Daily

Build physical activity naturally into your day, such as walking everywhere you need to go, rather than solely relying on structured exercise, as seen in Blue Zones.

18. Increase Movement After 50

After the age of 50, aim to do a little bit more of your enjoyable physical movement or exercise each year, defying the societal expectation to slow down.

19. Maintain Purposeful Physical Routines

Establish and maintain purposeful physical routines throughout your life, like chopping firewood, as this consistent activity contributes to healthy longevity.

20. Always Take the Stairs

Make it a rule to always take the stairs instead of lifts or escalators, such as at airports or work, to consistently build movement into your daily routine.

21. Park Further Away

When driving to destinations like the supermarket, intentionally park in the furthest spot from the entrance to increase your daily walking distance.

22. Choose Active Transport for Errands

For short errands like grocery shopping, give yourself extra time to walk or cycle instead of driving, integrating physical activity into your daily routine.

23. Spend More Time in Nature

Actively seek to spend more time in nature, whether green spaces or by the sea, as its positive impact on well-being is often underestimated and is a common factor in Blue Zones.

24. Avoid Stressful Health Tracking

If tracking health metrics like exercise or diet causes you stress, consider avoiding it, as stress itself is detrimental to the aging process.

25. Adopt Plant-Based Diet

Consider adopting a predominantly plant-based diet, as this is a common characteristic shared by people in Blue Zones who experience exceptional healthy longevity.

26. Avoid Processed Foods, Low Salt/Sugar

Minimize or eliminate processed foods, and ensure your diet is low in salt and sugar, as these are common habits in Blue Zones.

27. Eat to 80% Full

Adopt the practice of eating until you are about 80% full, rather than to complete satiation, as observed in Blue Zones for healthy longevity.

28. Use Smaller Plates

Use smaller plates for your meals, as this practice, observed in Blue Zones, can help you consume less food without deliberate calorie restriction.

29. Eat Less Frequently

Adopt the habit of eating less frequently throughout the day, as this contributes to calorie restriction and is a common practice in Blue Zones.

30. Add Food Variety Annually

Make an effort to put a bit more variety into your food every year, thinking of something different to try.

31. Avoid Tyramine-Rich Foods Before Bed

Avoid foods high in tyramine, such as blue cheeses, preserved meats, and bolognese sauce, before bed, as they can stimulate your fight-or-flight system and keep you awake.

32. Eat Tryptophan-Rich Foods for Sleep

Incorporating tryptophan-rich foods like cottage cheese, almonds, fatty fish (e.g., salmon), and certain teas into your diet can aid relaxation and sleep.

33. Eat Fatty Fish for Sleep

Consume fatty fish like salmon three times a week before bed, as studies suggest it can significantly improve sleep quality, likely due to its omega oil content.

34. Mind High-Fiber Foods Before Bed

Be mindful that consuming high-fiber foods close to bedtime may impact sleep quality due to the increased digestive activity required to break them down.

35. Try Pink/White Noise for Sleep

Consider experimenting with pink noise or white noise, or technologies that synchronize noise with brain waves, as they may help improve sleep quality by influencing brain wave rhythms.

36. Hot Bath/Shower Before Sleep

Try taking a hot bath or shower before sleep, as some individuals find this helps them relax and promotes better sleep.

37. Chilling Period Before Bed

Implement a chilling period of about an hour before bed, engaging in relaxing activities like reading or meditating to de-stress and prepare your body for sleep.

38. Exercise During Day, Not Before Bed

Exercise during the day to help with sleep, but avoid it immediately before bed, as it triggers your autonomic nervous system, making it harder to fall asleep.

39. Ensure Dark Bedroom

Ensure your bedroom is completely dark to support your body’s natural circadian rhythm and improve sleep quality.

40. Choose In-Person Over Virtual

Prioritize in-person classes and social activities over convenient virtual options, as relying too heavily on virtual interactions can be long-term toxic to social engagement.

41. Actively Reconnect Socially

Recognize that many people struggle to reconnect socially after periods of isolation; as individuals, be aware of this and actively reach out to others.

42. Foster Strong Community Bonds

Actively foster strong social engagement, networks, and infrastructure within your community, including multi-generational interaction and civic participation, as seen in the Rosetta study for longevity.

43. Foster Intergenerational Friendships

Make an effort to foster intergenerational friendships, where younger people spend time with older friends and vice versa, as this exchange of knowledge and experience is mutually beneficial.

44. Avoid Isolation, Stay Engaged

Actively seek constant engagement and avoid isolation, as continuous social interaction and variety contribute significantly to longevity.

45. Reconnect with Old Friends

Actively reach out to and reconnect with old friends, using group chats to facilitate regular in-person meet-ups, as these relationships are precious and enriching.

46. Question Convenience for Health

Recognize that convenience isn’t always what’s best for your health; critically evaluate convenient choices that may erode natural movement and engagement.

47. Reduce Alcohol Intake

Consider reducing your alcohol intake or having long periods of abstinence, as this is a beneficial lifestyle change that is becoming more socially acceptable.

48. Early Choices Impact Later Life

Recognize that lifestyle choices made in your 20s can have a significant impact on your health and aging process in your 80s, making early engagement important.

49. Maintain Healthy Blood Pressure Early

Understand that having even slightly higher blood pressure in your 20s can set you on a higher trajectory for the rest of your life, so aim for a lower, healthy blood pressure early on.

50. Mitigate Early Life Risks

Be aware that adverse childhood experiences and early life behaviors like smoking and alcohol consumption can accelerate biological aging, impacting health later in life.

51. Prepare for Menopause in Midlife

Women in their 40s should begin preparing for menopause, as it is a significant life stage that can be managed proactively.

52. Make Changes Despite Limitations

Understand that it’s never too late to make beneficial lifestyle changes; even with physical limitations, engaging in adapted exercise can lead to overall health benefits and epigenetic improvements.

53. Recover from Temporary Sleep Deprivation

If you experience temporary sleep deprivation, aim to return to your normal sleep rhythm when possible, as there’s little evidence of long-term negative impact on the aging process from such periods.

54. Acknowledge Sleep Challenges Without Anxiety

If you are a young parent or night shift worker struggling with sleep, acknowledge the difficulty without becoming anxious, as anxiety about sleep can be counterproductive.

55. Do Something, Not Nothing

Recognize that health improvements are not an ‘all or nothing’ endeavor; strive to do at least some of the known beneficial actions, even when life is challenging.

56. Focus on Quality Relationships

Emphasize the quality, not quantity, of your relationships and friendships, as this is what truly makes a difference in the aging process.

57. Embrace New Creativity, Purpose

Change and introduce new elements of creativity and purpose into your life every year, ensuring you always have something new you want to do.

58. Seek Variety in Life

Prioritize variety on your plate, in your daily life, and in your exercise regime, as these elements are crucial for healthy aging.

59. Combine Home & In-Person Classes

If you engage in home-based exercise, still sign up for and attend weekly in-person classes to gain the crucial benefits of social engagement beyond the physical activity itself.

60. Prioritize Face-to-Face Meetings

Choose face-to-face meetings over virtual ones, even if it takes more time, as they lead to better outcomes and build physical activity into your day.

61. Advocate for Universal Education

Recognize that education drives better quality of life, less stress, and higher income in later life, and advocate for its protection and accessibility for everybody.

62. Prioritize Human Connection in Crises

Advocate for policies that prioritize human connection and family presence during crises, learning from the catastrophic effects of social isolation experienced during COVID-19.

63. Combat Ageist Attitudes

Actively challenge and resist negative, ageist attitudes from media and individuals, as these can negatively impact your own and others’ perceptions of aging.

64. Embrace Improving Quality of Life

Cultivate a positive perspective on aging, knowing that quality of life generally improves from age 50 and doesn’t typically decline to that baseline level until age 84.

65. Get Erectile Dysfunction Checked

If you experience erectile dysfunction, particularly in midlife, consult a doctor as it can be an early indicator of underlying atherosclerosis or early-stage diabetes, requiring investigation.

66. Address Vaginal Dryness

If experiencing vaginal dryness, especially post-menopausally, discuss it with your doctor, as it can be effectively managed with hormone replacement therapy, local hormone therapy, or gels to improve comfort and intimacy.

67. Engage in Intimacy for Anti-Aging

Engage in intimacy, as its neurohumoral consequences, involving nerves and hormones, can decelerate the aging process by attenuating cellular inflammation.