Check for Alzheimer’s markers early to prevent progression, as early intervention significantly improves outcomes and can reverse cognitive decline, much like with cancer or diabetes.
Get genetic testing for APOE4 if you are 35 years of age or older to understand your genetic risk for Alzheimer’s, empowering you to take proactive steps rather than living in fear.
Regularly check blood-based biomarkers like phospho-tau, A-beta 42 to 40 ratio, GFAP, and NFL every five years from age 35, and every two years from age 60, to monitor brain health status and detect early signs of decline.
Address Alzheimer’s by identifying and optimizing multiple contributing factors (e.g., metabolic, inflammatory, toxic, infectious) rather than focusing on a single treatment, as cognitive decline results from a network insufficiency.
Implement a plant-rich, mildly ketogenic diet (Ketoflex 12/3) with at least 12 hours of overnight fasting and no eating for 3 hours before bed. Aim for metabolic flexibility and target ketone levels of 1.0-2.0 mmol/L (for symptomatic individuals) or 0.7-0.9 mmol/L (for prevention).
Monitor sleep using wearables, aiming for at least 7 hours total sleep, 90 minutes of REM sleep, 60 minutes of deep sleep, and an SpO2 of 94% or above. Screen for and treat sleep apnea, a common contributor to cognitive decline.
Incorporate a combination of strength training and aerobic exercise (potentially including HIIT) into your routine. This improves blood flow, insulin sensitivity, and overall brain function.
Actively reduce and manage chronic stress, as it is a common contributor to cognitive decline and switches the brain from a state of connection to protection. Prioritize activities that bring joy and social interaction.
Engage in practices like saunas (infrared preferred, 5-6 times/week), maintain optimal gut function with a high-fiber diet, and drink filtered water to eliminate toxins. Actively reduce exposure to environmental toxins by avoiding plastics (especially with hot foods/drinks) and consuming low-mercury fish (e.g., SMASH fish); for significant mycotoxin exposure, consider binders and removing the source.
Consider targeted supplements based on individual needs, such as active B12, methylfolate, and P5P to keep homocysteine levels below 7. Also, optimize vitamin D levels, consider 5-10mg of lithium orotate, and explore resolvins to reduce inflammation.
Engage in brain training and other forms of brain stimulation (e.g., light, sound, microcurrent) only after ensuring the brain is adequately supported through diet, sleep, and supplements, to avoid overtaxing a distressed brain.
Investigate and treat underlying infections (e.g., tick-borne illnesses, oral pathogens like P. gingivalis, T. denticola, influenza, Chlamydia pneumonia, long COVID) that contribute to inflammation and cognitive decline.
Correct sensory losses, such as hearing impairment with hearing aids, to maintain neural input to the brain and reduce the risk of cognitive decline, as hearing loss is a common risk factor.
Take the free 20-minute MyCQTest.com online cognitive assessment to assess your current cognitive status and guide your prevention or treatment strategy.
Consult with medical professionals trained in Dr. Bredesen’s protocol (found via MyCQTest.com or DrBredesen.com) and inquire about their success rates and patient outcomes to ensure effective, personalized treatment.