Qualy #24 - What are the "ABCs" of Alzheimer's prevention?

Today's episode of The Qualys is from podcast <a href="https://peterattiamd.com/richardisaacson/">#18 – Richard Isaacson, M.D.: Alzheimer's prevention</a>. The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for "qualifying round," which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., "fast"), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive. Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now. Learn more: <a href="https://peterattiamd.com/podcast/qualys/">https://peterattiamd.com/podcast/qualys/</a> Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): <a href="https://peterattiamd.com/subscribe/">https://peterattiamd.com/subscribe/</a> Connect with Peter on <a href="http://facebook.com/PeterAttiaMD%5dFacebook">Facebook.com/PeterAttiaMD</a> | <a href="http://twitter.com/PeterAttiaMD%5dTwitter">Twitter.com/PeterAttiaMD</a> | <a href="http://instagram.com/PeterAttiaMD%5dInstagram">Instagram.com/PeterAttiaMD</a>

Actionable Insights

1. Prioritize Alzheimer’s Prevention Funding

Advocate for a significant shift in Alzheimer’s research funding towards prevention (e.g., 10-90% prevention-treatment split), acknowledging that current drug development has a 0.4% success rate and prevention offers a much bigger impact.

2. Embrace Lifestyle Changes for Prevention

Prioritize difficult but impactful lifestyle changes like sleep, meditation, exercise, and diet for Alzheimer’s prevention, as evidence suggests these behaviors have a greater effect than solely relying on medication.

3. Personalized Precision Medicine Plan

Seek a personalized precision medicine approach for Alzheimer’s prevention by integrating your individual data on cholesterol, inflammation, metabolism, nutrition biomarkers, genetics, body fat, and cognitive function to create an effective, tailored plan.

4. Deep Dive Body Composition Analysis

For Alzheimer’s prevention, focus on detailed anthropometric analysis beyond just weight and BMI, examining body fat, lean mass, and the location of metabolically active visceral fat.

5. Comprehensive Blood Biomarker Analysis

For Alzheimer’s prevention, get detailed blood-based biomarker profiling, including advanced cholesterol markers (ApoB, LDL-P, particle subtype) and inflammatory markers (high-sensitivity CRP, fibrinogen, myeloperoxidase, LP-PLA2), with hSCRP noted as most informative.

6. Implement High-Intensity Interval Training

To effectively lose weight and body fat, engage in high-intensity interval training (HIIT) instead of only moderate exercise like 20 minutes on an elliptical three times a week, tailoring the approach to your individual biology.

7. Monitor Biomarkers for Progress

Regularly review your biomarkers with your doctor to track how lifestyle changes impact your health, using this feedback for positive reinforcement and to make necessary adjustments to your plan.

8. Utilize Free Prevention Education

Access free online educational resources that provide interactive content on Alzheimer’s prevention to learn and impact your health, as these tools can reach many people while experts are sleeping.

9. Insight 9

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