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#324 ‒ Metabolism, energy balance, and aging: How diet, calorie restriction, and macronutrients influence longevity and metabolic health | Eric Ravussin, Ph.D.

Nov 4, 2024 2h 9m 23 insights
<p><a href="https://peterattiamd.com/ericravussin/?utm_source=podcast-feed&amp;utm_medium=referral&amp;utm_campaign=241103-pod-ericravussin&amp;utm_content=241103-pod-ericravussin-podfeed"> View the Show Notes Page for This Episode</a></p> <p><a href="https://peterattiamd.com/subscribe/?utm_source=podcast-feed&amp;utm_medium=referral&amp;utm_campaign=241103-pod-ericravussin&amp;utm_content=241103-pod-ericravussin-podfeed"> Become a Member to Receive Exclusive Content</a></p> <p><a href="https://peterattiamd.com/newsletter/?utm_source=podcast-feed&amp;utm_medium=referral&amp;utm_campaign=241103-pod-ericravussin&amp;utm_content=241103-pod-ericravussin-podfeed"> Sign Up to Receive Peter's Weekly Newsletter</a></p> <p>Eric Ravussin is a world-renowned expert on obesity, metabolism, and aging whose pioneering research has shaped much of what we understand today about energy balance and caloric restriction. In this episode, Eric shares insights from his cutting-edge work on energy expenditure—a critical factor in understanding how our bodies regulate weight and appetite. He discusses methods for measuring energy output, energy balance, food intake, and appetite regulation, and explores key studies on macronutrient manipulation. Eric then delves into the CALERIE study on caloric restriction, highlighting insights related to biomarkers of both primary and secondary aging. The conversation also covers the potential of GLP-1 agonists to replicate these effects and looks ahead to how AI and technology could transform metabolic research in the coming years.</p> <p><strong>We discuss:</strong></p> <ul type="disc"> <li>Eric's background and current work metabolism and measuring energy expenditure [3:00];</li> <li>The science behind metabolic chambers for measuring energy expenditure, and the complexities of indirect and direct calorimetry [8:00];</li> <li>The body's regulatory systems for maintaining energy balance and the primary influence of energy intake on body weight [18:30];</li> <li>The epidemic of obesity and a discussion of resting metabolic rate [24:45];</li> <li>The impact of exercise, appetite, gut hormones, and eating patterns on weight regulation [28:45];</li> <li>Experiments looking at how macronutrient composition affects energy expenditure [38:45];</li> <li>The challenges of studying diet in real-life settings, the potential of personalized nutrition, and how public health policy could play a role in guiding nutritional habits [51:00];</li> <li>The importance of protein in the diet, the limitations of dietary data collection, and how AI could potentially transform nutrition science [1:08:15];</li> <li>How Eric's interest in caloric restriction (CR) began with Biosphere 2, metabolic efficiency's role in aging, and goals of the CALERIE study [1:15:15];</li> <li>The CALERIE study: exploring the real-world impact of caloric restriction [1:28:00];</li> <li>Notable findings from the CALERIE study after two years: sustained weight loss, participant retention, and more [1:40:00];</li> <li>The effect of caloric restriction on the hallmarks of aging [1:47:00];</li> <li>The challenge of applying CR to the general population, the potential of drugs and exercise to mimic the effects of CR [1:55:45];</li> <li>Upcoming study comparing caloric restriction to time-restricting eating, and Peter's takeaways from the discussion [2:02:45]; and</li> <li>More.</li> </ul> <p>Connect With Peter on <a href="https://twitter.com/PeterAttiaMD">Twitter</a>, <a href="https://www.instagram.com/peterattiamd/">Instagram</a>, <a href="https://www.facebook.com/peterattiamd/">Facebook</a> and <a href="https://www.youtube.com/channel/UC8kGsMa0LygSX9nkBcBH1Sg">YouTube</a></p>
Actionable Insights

1. Improve Cardiometabolic Health with CR

Caloric restriction (average 12.5% over two years) in healthy, non-obese individuals significantly improved all cardiovascular and cardiometabolic risk factors, effectively “gaining 10 years in two years” by Framingham Index. Consider caloric restriction for significant improvements in cardiometabolic health.

2. Boost Mitochondrial Health via CR

Caloric restriction increased mitochondrial biogenesis and reduced reactive oxygen species (ROS) production, suggesting improved mitochondrial function and reduced oxidative stress. Consider caloric restriction for improving mitochondrial function and reducing oxidative stress.

3. Reduce Inflammation with CR

Caloric restriction significantly improved chronic inflammation markers (e.g., CRP, interleukins, TNF-alpha) and reduced fat in the thymus, indicating improved immune function. Consider caloric restriction to reduce chronic inflammation and improve immune health.

4. Personalize Your Nutrition Strategy

Acknowledge that “one size does not fit all” for diet and health, and different strategies and restrictions are needed for groups of people. Seek personalized nutrition strategies rather than universal dietary guidelines.

5. Implement Sustainable Dietary Restriction

Accept that living in an “infinite food environment” requires some form of restriction (macronutrients, alcohol, eating window, or direct calories) for weight balance. Identify and implement a sustainable form of dietary restriction.

6. Combine Nutrition and Exercise

A nutritional approach to weight loss without prescribed physical activity or exercise is not a good strategy; both should be implemented. Combine nutritional approaches with physical activity for weight loss.

7. Exercise for Autophagy & Health

Exercise is an incredibly potent driver of autophagy, a cellular process that cleans out damaged cells and is also fueled by caloric restriction. Engage in regular exercise to promote autophagy and cellular health.

8. Vigorous Exercise Curbs Appetite

Vigorous exercise can be anorectic (reduces appetite), possibly driven by lactate. Consider vigorous exercise to temporarily reduce appetite.

9. Eat Slowly Post-Exercise

Be mindful of eating speed after exercise, as eating too quickly can abrogate the energy effect of exercise. Eat slowly after exercise to better regulate intake.

10. Optimize Gut Hormone Regulation

The speed of food delivery to the stomach is important for the kinetics of gut hormones (GLP-1, GIP, CCK, PY-1, Glucagon) which regulate food intake. Eat slowly to optimize gut hormone regulation of intake.

11. Prioritize Sufficient Protein Intake

The protein leverage theory suggests people eat for a given amount of protein; if protein density in food decreases, people might increase caloric intake to get sufficient protein. Ensure sufficient protein intake to potentially regulate overall caloric intake.

12. Ketogenic Diet for Initial Weight Loss

A ketogenic diet (less than 10% carbohydrate) can lead to a slight, statistically significant increase in sleeping metabolic rate and 24-hour energy expenditure (around 100 calories/day) in the early weeks. It may also have a slight advantage for weight loss during the weight loss period compared to a low-fat diet.

13. Manage Hunger During CR

Sustained caloric restriction is “totally manageable” for most people after about one month, especially when increasing food volume and decreasing fat content to maintain satiety. If attempting caloric restriction, understand that initial hunger subsides, and focus on high-volume, low-calorie-density foods.

14. Consider GLP-1 Agonists

GLP-1 agonists are potent modulators of food intake and lead to significant weight loss and metabolic health improvements. Discuss GLP-1 agonists with a healthcare professional for weight management and metabolic health.

15. Exercise for Weight Loss Maintenance

Physical activity is key for weight loss maintenance, as shown by the weight registry, where successful maintainers engaged in more physical activity. Incorporate physical activity for weight loss maintenance.

16. Exercise Alone Not for Weight

Exercise alone is “pretty bad for weight loss” and is a “B minus at best” in terms of evidence for its role in weight loss. Adjust expectations for exercise as a primary weight loss tool.

17. Understand Personal Metabolic Needs

Understand that individuals have varying metabolisms, meaning some may need to be very restrictive, others moderately mindful, and some less restrictive to maintain weight balance. Assess personal metabolic needs and adjust dietary mindfulness/restriction accordingly.

18. Seek Support for Changes

Building a strong relationship with investigators/coordinators, sharing results, and fostering a community among participants were key to exceptional adherence and retention in a two-year caloric restriction study. When undertaking significant lifestyle changes, seek strong support systems, track progress, and engage with a supportive community.

19. Leverage Health Interventions Long-Term

Many participants in the CALERIE study maintained some weight loss and continued to use learned strategies more than 15 years after the study, indicating lasting lifestyle changes. View participation in structured health interventions as an opportunity for long-term lifestyle change and learning.

20. Be Aware of CR Efficiency

Caloric restriction leads to metabolic adaptation, making the body more efficient (burning less energy than expected for body weight). Be aware that caloric restriction can lead to increased metabolic efficiency, which might make further weight loss harder but could be beneficial for longevity.

21. Seek Better Nutrition Education

Better public education and advocacy from scientific/medical communities are needed to help people understand that they are not “broken” if average approaches don’t work, and to empower them to find personalized solutions. Seek out better education and advocacy on personalized nutrition.

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