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<p><a href="https://peterattiamd.com/ama62/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=240812-pod-ama62&utm_content=240812-pod-ama62-podfeed"> View the Show Notes Page for This Episode</a></p> <p><a href="https://peterattiamd.com/subscribe/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=240812-pod-ama62&utm_content=240812-pod-ama62-podfeed"> Become a Member to Receive Exclusive Content</a></p> <p><a href="https://peterattiamd.com/newsletter/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=240812-pod-ama62&utm_content=240812-pod-ama62-podfeed"> Sign Up to Receive Peter's Weekly Newsletter</a></p> <p>In this "Ask Me Anything" (AMA) episode, Peter dives into two important health topics: uric acid and protein, examining them from unique perspectives. For uric acid, he explores its metabolic role and connection to various diseases, focusing on the potential causal link with cardiovascular disease. He also discusses factors influencing uric acid levels, such as diet, genetics, and lifestyle, providing practical tips for effective management. Shifting to protein, Peter delves into its role in appetite and weight management, the consequences of insufficient protein, and the "protein leverage hypothesis" linking protein deficiency to obesity. He covers optimal protein intake and its impact on energy expenditure, and he compares the satiety effects of solid versus liquid protein. Finally, Peter shares his strategy for incorporating protein into a comprehensive weight management plan.</p> <p>If you're not a subscriber and are listening on a podcast player, you'll only be able to hear a preview of the AMA. If you're a subscriber, you can now listen to this full episode on your <a href="https://peterattiamd.com/members/private-podcast-feed/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=240812-pod-ama62&utm_content=240630-pod-ama62-podfeed">private RSS feed </a>or our website at the <a href="http://peterattiamd.com/ama62/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=240812-pod-ama60&utm_content=240812-pod-ama62-podfeed">AMA #62 show notes page</a>. If you are not a subscriber, you can learn more about the subscriber benefits <a href="https://peterattiamd.com/subscribe/?utm_source=podcast-feed&utm_medium=referral&utm_campaign=240812-pod-ama62&utm_content=240812-pod-ama62-podfeed">here</a>.</p> <p><strong>We discuss:</strong></p> <ul type="disc"> <li>Overview of episode topics (and an important discussion on fanny packs) [2:00];</li> <li>Understanding uric acid: its role in metabolic processes, its association with gout and kidney stones, its impact on blood pressure, and more [6:00];</li> <li>Non-modifiable factors that influence uric acid levels [11:00];</li> <li>Modifiable factors that influence uric acid levels [14:15];</li> <li>Association between high uric acid levels and cardiovascular disease [20:00];</li> <li>Evidence suggesting a causal link between high uric acid levels and cardiovascular disease [24:00];</li> <li>Inconclusive evidence about the cardiovascular benefits of lowering uric acid pharmacologically [28:15];</li> <li>Exploring the potential risks of low uric acid levels in neurodegenerative diseases [37:00];</li> <li>Managing uric acid levels: dietary interventions and pharmacological approaches [42:00];</li> <li>The impact of protein on appetite and weight management [44:00];</li> <li>The consequences of insufficient protein on eating behaviors and satiety [52:15];</li> <li>The relationship between protein deficiency and obesity: exploring the "protein leverage hypothesis" [57:15];</li> <li>The impact of protein intake on energy expenditure [1:02:15];</li> <li>Determining optimal protein intake to avoid deficiency and support health [1:05:45];</li> <li>The role of different amino acids and protein sources in promoting satiety [1:08:15];</li> <li>Comparing the satiety effects of solid vs. liquid protein sources [1:10:30];</li> <li>Peter's framework for incorporating protein intake into a strategy for controlling body weight [1:12:00]; and</li> <li>More.</li> </ul> <p>Connect With Peter on <a href="https://twitter.com/PeterAttiaMD">Twitter</a>, <a href="https://www.instagram.com/peterattiamd/">Instagram</a>, <a href="https://www.facebook.com/peterattiamd/">Facebook</a> and <a href="https://www.youtube.com/channel/UC8kGsMa0LygSX9nkBcBH1Sg">YouTube</a></p>
Actionable Insights
1. Reduce Fructose Intake
Decrease chronic consumption of high amounts of fructose, especially in liquid form, as it drives uric acid production and can contribute to increased eating and obesity.
2. Limit High-Purine Foods & Alcohol
Reduce intake of foods very high in purines, such as sardines, red meat, and high amounts of alcohol (disproportionately beer), to decrease uric acid production.
3. Monitor Uric Acid During Ketosis/Fasting
Be aware that being in nutritional ketosis or starvation ketosis (fasting) can significantly increase uric acid levels due to competition with beta-hydroxybutyrate in the kidneys.
4. Prioritize Protein for Satiation
Utilize protein intake to impact appetite and satiation, which can help in weight control and prevent protein deficiency-related obesity.
5. Lower Uric Acid for CVD Risk
Understand that if uric acid is causally related to cardiovascular disease, then actively lowering uric acid levels would reduce the risk of cardiovascular disease.
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