Adopt a ‘press pulse’ strategy for cancer by constantly reducing glucose (via diet/drugs) and periodically reducing glutamine (via drugs). This aims to starve tumor cells of their fermentable fuels while protecting normal cells.
Maintain a glucose-ketone index (GKI) of 1.0 or below by significantly lowering blood sugar and elevating ketones through diet and supplementation. This creates a selective metabolic disadvantage for tumor cells and enables other targeted therapies.
Refrain from using radiation therapy for glioblastoma (GBM) patients, as it can cause radiation necrosis, elevate blood sugar, and release glutamine. These effects may worsen patient outcomes and quality of life.
Utilize hyperbaric oxygen as a pulse therapy (e.g., 2.5 atmospheres for 90 minutes daily) to create oxidative stress specifically in tumor cells. This should only be done when the patient is in therapeutic ketosis.
Use glutamine-blocking drugs (e.g., Don, 6-norleucine) in a pulsed manner to deprive tumor cells of this essential fuel. This strategy must be carefully managed to avoid compromising the normal immune system and gut health.
Delay surgical debulking until metabolic therapy has shrunk the tumor, reduced inflammation, and made its margins more defined. This approach aims for a more complete and potentially curative resection.
Implement stress-reducing practices like music therapy and yoga to lower corticosteroids, which can otherwise hinder blood sugar control and the effectiveness of metabolic therapies. Inform patients that stress reduction helps the treatment work.
Administer insulin therapy to further lower blood sugar, but only when the patient is already in a state of therapeutic ketosis. This ensures glucose reduction without stimulating tumor growth, which insulin can do with high glucose.
Maintain mitochondrial health by avoiding known risk factors such as viral infections, intermittent hypoxia, radiation exposure, and exposure to carcinogens. Healthy mitochondria are crucial for preventing cancer.
Be aware that needle biopsies, while diagnostic, may potentially create an aggressive inflammatory environment that could facilitate tumor spread or metastasis. Consider the risks versus the diagnostic benefits.
Do not use Avastin (bevacizumab) for cancer treatment, particularly for breast and brain cancers. This anti-angiogenic drug has been shown to harm more patients than it helps and can promote invasive tumor behavior.
For epilepsy management, keep blood sugar levels consistently low (e.g., 65-70 mg/dL) and avoid spikes (e.g., to 120 mg/dL). Even slight elevations can trigger breakthrough seizures.
Engage in calorie restriction for health benefits, but ensure it does not lead to muscle breakdown. Breaking down muscle indicates entering a pathological starvation mode that should be avoided.
Refrain from chronic yo-yo dieting, as it can have long-term detrimental effects on physiological systems. The body’s ’thrifty physiology’ can be negatively impacted.
Contribute financially to foundations (e.g., Single Cause Single Cure Foundation, Travis Foundation, Metabolic Therapy Foundation) or directly to university labs (with specific funding statements) to advance research in metabolic cancer therapies.
Support and advocate for clinical trials that rigorously test metabolic therapies for cancer, especially as a primary treatment or in combination with minimal conventional treatments, to challenge existing standards of care.
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