Avoid taking really high doses of nicotinamide (Vitamin B3) as it acts as an inhibitor of sirtuins, which are important for longevity pathways.
Consult the Josh Rabinowitz paper in Cell Metabolism (linked in show notes) for a potentially compelling case regarding the futility of orally administered NAD precursors.
Take resveratrol with a fatty food, such as oil or yogurt, to significantly improve its absorption and increase blood levels.
When combining multiple longevity-focused molecules like metformin and resveratrol, start with a reasonable low dose and gradually increase, monitoring well-being and blood tests due to potential additive effects and unknown interactions.
Prioritize NAD precursors (like NMN or NR) over single sirtuin activators (like resveratrol) for broader activation of all seven sirtuins and to replenish age-related NAD decline, as NMN has shown lifespan extension in wild-type mice.
Consider David Sinclair’s personal regimen of taking resveratrol, metformin, and NMN, acknowledging it’s an individual experiment based on available data for potential health benefits.
Do not trust over-the-counter supplements that claim to be endorsed by David Sinclair, as he does not endorse any products.
Store NAD precursors like NMN and NR in the freezer to maintain their stability and extend their shelf life.
Recognize that claims of significant performance improvement from NAD precursors (NR/NMN) are currently anecdotal and lack placebo-controlled evidence, requiring caution.
Understand that measuring NAD precursor effects is complex; blood levels don’t necessarily reflect tissue uptake or activity, and advanced studies are ongoing to clarify distribution.
Develop massive determination and grit, as demonstrated by David Sinclair’s career path, to overcome challenges and achieve ambitious life goals.
Advocate for or support large-scale human clinical trials (e.g., 5,000 people in their 70s for 3-4 years) to definitively assess the impact of longevity drugs on mortality rates.
Look for David Sinclair’s book, expected in late summer/early fall 2019, for a comprehensive understanding of aging, his universal hypothesis, and societal implications.
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