← The Peter Attia Drive

#239 ‒ The science of strength, muscle, and training for longevity | Andy Galpin, Ph.D. (PART I)

Jan 23, 2023 2h 35m 20 insights
<p><a href="https://peterattiamd.com/andygalpin/?utm_source=podcast-feed&amp;utm_medium=referral&amp;utm_campaign=230123-pod-andygalpin&amp;utm_content=230123-pod-andygalpin-podfeed"> View the Show Notes Page for This Episode</a></p> <p><a href="https://peterattiamd.com/subscribe/?utm_source=podcast-feed&amp;utm_medium=referral&amp;utm_campaign=230123-pod-andygalpin&amp;utm_content=230123-pod-andygalpin-podfeed"> Become a Member to Receive Exclusive Content</a></p> <p><a href="https://peterattiamd.com/newsletter/?utm_source=podcast-feed&amp;utm_medium=referral&amp;utm_campaign=230123-pod-andygalpin&amp;utm_content=230123-pod-andygalpin-podfeed"> Sign Up to Receive Peter's Weekly Newsletter</a></p> <p>Andy Galpin is a Professor of Kinesiology at California State University at Fullerton, where he studies muscle adaptation and applies his research to work with professional athletes. In this episode, Andy sets the foundation for the conversation by discussing the anatomy, microanatomy, and physiology of the muscle, including explaining what it actually means to undergo hypertrophy of the muscle. He then explains the difference between power, strength, speed, and hypertrophy and how those differences relate to what's happening at the cellular level and the functional unit level. Additionally, he discusses energy sources for muscles, the importance of protein for muscle synthesis, the various types of muscle fibers, and the factors that determine one's makeup of muscle fibers. Finally, Andy wraps the conversation with how he would design a program for an untrained person committed to adding muscle and functional strength for longevity.</p> <p><strong>We discuss:</strong></p> <ul type="disc"> <li>Andy's path to expertise in exercise [3:30];</li> <li>Contrasting strength, power, and force production and how they inform us about training for longevity [9:30];</li> <li>Muscle energetics: Fuels that provide energy to muscles, and the importance of protein [17:45];</li> <li>The structure and microanatomy of muscle, muscle fibers, and more [29:30];</li> <li>Energy demands of skeletal muscle compared to other tissues in the body [39:45];</li> <li>How a muscle contraction works and why it requires ATP [48:00];</li> <li>Muscle fibers: modulation between fiber types with movement and changes in fibers with training and aging [53:15];</li> <li>Andy's study of twins demonstrating the difference in muscle fibers between a trained and untrained individual [1:02:30];</li> <li>Microanatomy of fast-twitch and slow-twitch muscle fibers [1:11:15];</li> <li>Factors that determine one's makeup of muscle fibers and how adaptable they are with training [1:22:15];</li> <li>Hypertrophy and what happens at the cellular level when a muscle grows [1:30:00];</li> <li>How athletes quickly cut water weight and the rehydration process [1:37:30];</li> <li>Different types of athletes [1:47:30];</li> <li>Training advice for a hypothetical client who's untrained and wants to add muscle and functional strength for longevity [1:49:45];</li> <li>Changes in muscle and muscular function that occur with aging [1:53:45];</li> <li>Training plan for the hypothetical client [1:59:30];</li> <li>What drives muscle hypertrophy? [2:12:15];</li> <li>How to properly incorporate isometric exercises into a workout [2:19:00];</li> <li>Additional training tips: movement patterns, how to finish a workout, and more [2:25:45];</li> <li>Ways to incorporate high heart rate exercise into a workout plan [2:28:45]; and</li> <li>More.</li> </ul> <p>Connect With Peter on <a href="https://twitter.com/PeterAttiaMD">Twitter</a>, <a href="https://www.instagram.com/peterattiamd/">Instagram</a>, <a href="https://www.facebook.com/peterattiamd/">Facebook</a> and <a href="https://www.youtube.com/channel/UC8kGsMa0LygSX9nkBcBH1Sg">YouTube</a></p>
Actionable Insights

1. Prioritize Exercise for Longevity

Prioritize exercise above nutrition, sleep, medication, supplements, drugs, and hormones for improving longevity and quality of life, as it is presented as the most potent tool.

2. Maintain Muscle for Systemic Health

Maintain muscle mass not just for locomotion, but because it’s the body’s largest organ, serving as a crucial reserve for amino acids needed for cell building and playing a significant role in regulating glucose and overall metabolism.

3. Ensure Sufficient Protein Intake

Ensure sufficient protein intake as it is the raw material for muscle and other bodily functions; insufficient protein can lead to muscle loss and redistribution from less-used areas to more critical needs like the immune system.

4. Target Fast Twitch Fibers

Actively train fast twitch muscle fibers, as they are essential for preserving physical function and power with aging, and unlike slow twitch fibers, they require intentional high-force production training to prevent atrophy and loss.

5. Muscle Fiber Types Adaptable

Understand that muscle fiber types are highly plastic and can change dramatically with training, even in older adults (e.g., 70-year-olds seeing changes in 6-8 weeks), indicating that it’s never too late to adapt muscle composition.

6. Start Strength Training Low Volume

For untrained individuals, begin strength training with very low volume (1-3 working sets of 4 compound exercises per session, 3x/week), focusing intensely on mastering movement patterns and proper form to prevent excessive soreness and build a solid foundation.

7. Prioritize Compound Movements Initially

Initially focus on compound movements (e.g., goblet squats, hip extensions, overhead presses, bent rows) rather than isolated single-joint movements to build foundational strength, practice essential movement patterns, and minimize injury risk.

8. Minimize Eccentric Movements Soreness

Be cautious with eccentric movements, especially when starting strength training, as they generate more soreness; focus on concentric movements or controlled eccentrics to prevent dissuading further training.

9. Don’t Fear Accidental Muscle

Do not fear becoming ’too big’ from strength training, as significant muscle gain requires intentional, dedicated effort and does not happen accidentally, especially for individuals who are not genetically predisposed or training intensely.

10. Incorporate Power and Speed Training

Dedicate 10-15 minutes at the start of each workout to power and speed movements (e.g., box jumps landing on the box, medicine ball throws/slams, 70% sprints, jump rope, multi-planar athletic movements) to improve foot speed, eccentric strength for fall prevention, and overall functional athleticism for longevity.

11. Implement Full-Body, Varied Reps

Structure strength training as full-body workouts three times a week, varying rep ranges: e.g., 3-4 sets of 5-7 reps at RPE 7-8 on Monday, 15-20 reps per set on Wednesday, and isometric holds on Friday, as all are effective for hypertrophy.

12. Incorporate Isometric Training

Include isometric holds (e.g., wall squats, RDL holds against a rack) in your training, as they are equally effective for hypertrophy as isotonic movements, build strength in specific ranges of motion, improve joint and connective tissue health, and reduce injury risk.

13. Train Isometrics at End Range

When performing isometric exercises, aim to hold positions closer to the end range of motion or where the muscle is at its highest stretch, as this provides a strong signal for muscle growth and can be particularly effective for hypertrophy.

14. Use Isometrics for Max Force

Utilize isometric exercises, especially for individuals with a low training age, to safely practice expressing maximum force output in specific positions (e.g., pushing against an immovable bar in a squat or RDL) without the complexity and risk of free-range motion.

15. Train Multiple Planes Unilaterally

Ensure your strength training includes movements in all three planes (frontal, sagittal, transverse) and incorporates single-leg or split-stance exercises (e.g., step-ups, split squats) to develop balanced strength and address stability.

16. Balance Machine and Free Weights

For new trainees, balance machine-based exercises (for safety and ease of learning) with free weights (barbells, dumbbells, kettlebells) to avoid being held back by technical demands while still investing in long-term functional development.

17. Vary Power/Speed Activities Daily

To maintain engagement and target different movement patterns, vary the power and speed activities across the three weekly workouts (e.g., medicine ball drills on Monday, pickleball on Wednesday, jumps/plyometrics on Friday).

18. Finish with High Heart Rate

Conclude each training session with either a short, intense burst to achieve a high heart rate (e.g., 10-second all-out air bike sprint followed by a max breath hold and 30-second nasal-only recovery, repeated 1-3 times) or a ‘blast’ of exercises targeting a muscle group the individual enjoys, to ensure engagement and metabolic conditioning.

19. Increase Non-Exercise Activity (NEAT)

Increase non-exercise activity thermogenesis (NEAT) by staying active throughout the day (e.g., tapping foot, fidgeting) as it contributes significantly to daily energy expenditure and can help manage weight.

20. Manage BMR Increase Expectations

Understand that while increasing muscle mass does elevate basal metabolic rate, the caloric increase is modest (e.g., ~30 calories per pound of muscle), so don’t expect a dramatic metabolic boost from muscle gain alone.