← The Peter Attia Drive

#217 ‒ Exercise, VO2 max, and longevity | Mike Joyner, M.D.

Aug 8, 2022 1h 52m 25 insights
<p><a href="https://peterattiamd.com/mikejoyner/?utm_source=podcast-feed&amp;utm_medium=referral&amp;utm_campaign=220808-pod-mikejoyner&amp;utm_content=220808-pod-mikejoyner-podfeed"> View the Show Notes Page for This Episode</a></p> <p><a href="https://peterattiamd.com/subscribe/?utm_source=podcast-feed&amp;utm_medium=referral&amp;utm_campaign=220808-pod-mikejoyner&amp;utm_content=220808-pod-mikejoyner-podfeed"> Become a Member to Receive Exclusive Content</a></p> <p><a href="https://peterattiamd.com/newsletter/?utm_source=podcast-feed&amp;utm_medium=referral&amp;utm_campaign=220808-pod-mikejoyner&amp;utm_content=220808-pod-mikejoyner-podfeed"> Sign Up to Receive Peter's Weekly Newsletter</a></p> <p>Mike Joyner is a physician-researcher and one of the world's leading experts on human performance and exercise physiology. In this episode, Mike discusses how to combat age-related declines in health and fitness levels by using various modes of exercise to improve lifespan and healthspan. Mike explains the impact of exercise on the autonomic nervous system, blood pressure, heart rate, heart rate variability, heart rate recovery, and max heart rate. He dives deep into VO2 max, including how it's measured, what is driving it, and how to improve it. Mike provides training insights for the average person, including training volume and exercise intensity as well as simple metrics to track. Furthermore, he gives his take on the theoretical "J-curve" relationship between exercise and longevity, as well as whether possible health dangers may be associated with excessive exercise.</p> <p>We discuss:</p> <ul> <li>Mike's training as an anesthesiologist and interest in exercise physiology [2:30];</li> <li>How exercise increases longevity [7:00];</li> <li>The impressive data on the benefits of exercise [9:45];</li> <li>The Centenarian Olympics and other ways to mitigate age-related decline in strength and stability [15:00];</li> <li>The violent dropoff in strength and activity with age and how exercise preserves fitness in old age [19:00];</li> <li>Benefits of exercise on mortality and fracture risk, and the interplay of nutrition and exercise [22:00];</li> <li>How exercise benefits the autonomic nervous system and why this plays an important role in our health [26:30];</li> <li>VO2 max, heart rate recovery, heart rate variability, and other metrics of fitness positively impacted by exercise [28:30];</li> <li>Reduction in all-cause mortality with increased fitness levels and VO2 max [32:45];</li> <li>Does the relationship between exercise and longevity follow a J-curve? [40:00];</li> <li>Mitigating age-related decline in fitness by elevating your VO2 max at a young age [46:15];</li> <li>Breaking down the variables that drive VO2 max [54:30];</li> <li>Learning from elite athletes: Training regimens, aerobic efficiency, and other impressive metrics [1:00:15];</li> <li>Health benefits of light exercise for the average person [1:09:00];</li> <li>Simple training metrics to track, and Mike's current exercise regimen [1:11:15];</li> <li>How to boost your VO2 max, and the importance of form and tempo with interval training [1:18:15];</li> <li>Training advice for the average person [1:25:15];</li> <li>Why professional athletes have longer careers than they've had in the past [1:27:30];</li> <li>Use of performance-enhancing drugs in professional sports [1:29:45];</li> <li>Can the miracle of exercise be put in a pill? [1:36:00];</li> <li>Mike's current research and questions he's most interested in answering [1:39:00];</li> <li>Use of convalescent plasma to treat COVID-19 [1:41:15];</li> <li>Parting thoughts on the current state of fitness and exercise in society [1:47:15];</li> <li>More.</li> </ul> <p>Connect With Peter on <a href="https://twitter.com/PeterAttiaMD">Twitter</a>, <a href="https://www.instagram.com/peterattiamd/">Instagram</a>, <a href="https://www.facebook.com/peterattiamd/">Facebook</a> and <a href="https://www.youtube.com/channel/UC8kGsMa0LygSX9nkBcBH1Sg">YouTube</a></p>
Actionable Insights

1. Prioritize Exercise for Longevity

Recognize exercise as the single most impactful factor for extending both lifespan and healthspan, surpassing nutrition and medication in its potential to reduce all-cause mortality and improve quality of life.

2. Define Your Healthspan Goals

Create a ‘Centenarian Decathlon’ by identifying specific physical activities and daily living tasks you want to perform in your last decade (e.g., walking 3 miles in an hour, getting off the floor with one hand) and train deliberately to offset age-related decline.

3. Achieve Elite VO2 Max

Strive for a VO2 max in the top 2.5% for your age group, as this level of fitness is associated with the lowest all-cause mortality risk, a five-fold reduction compared to the least fit individuals.

4. Build VO2 Max for Future Decline

Aim for the highest possible VO2 max in your 40s and 50s to create a larger reserve, buffering the inevitable age-related decline (which can be reduced from 10% to 5-6% per decade with consistent training) and maintaining functional capacity into later life.

5. Incorporate Strength & Agility Training

As you age, especially from your forties and fifties, add strength, circuit, and agility training to your routine to combat the decline in skeletal muscle strength and frailty, which is crucial for preventing falls and maintaining independence.

6. Avoid Inactivity at All Costs

Actively avoid inactivity, as even short periods of bed rest can cause significant physiological decline equivalent to decades of aging. Engage in any form of physical activity, from low-grade movement to intentional workouts.

7. Boost VO2 Max with 4x4 Intervals

Implement a high-intensity interval training protocol of four minutes of all-out effort (e.g., on a bike or running) followed by four minutes of complete rest or very light recovery, repeated four times, to efficiently increase your VO2 max.

8. Adopt Polarized Training

Structure your exercise regimen with a polarized approach, alternating between ‘hard’ days of intense, structured workouts and ’easy’ days focused on active recovery to promote recuperation and loosen muscles.

9. Train to Train First

If you are previously untrained or older (60-70 years), dedicate 3-6 months to ‘pre-training’ at a moderate intensity (e.g., 80% of time at conversational pace) to build a foundational fitness level before introducing hard interval sessions.

10. Limit Hard Training Sessions

To prevent orthopedic issues, fatigue, and other load management problems, limit your hard training sessions to no more than five or six every two weeks, allowing adequate recovery.

11. Pace Intervals Strategically

When performing intervals, start at a sustainable pace where initial discomfort is minimal. Aim for consistent effort, with the most suffering concentrated in the last 90 seconds, and finish without needing to bend over, indicating optimal exertion without overdoing it.

12. Manage Suffering for Performance

During intense interval training, learn to ‘manage your suffering’ by maintaining rhythm, tempo, and form even as discomfort increases, pushing your limits while staying relaxed.

13. Engage in Daily Light Activity

Incorporate at least 10-15 minutes of light physical activity daily, such as purposeful walking, gardening, or taking the stairs, as this provides substantial health benefits like improved insulin sensitivity and better vascular function.

14. Incorporate Jump Roping

Use a jump rope as a versatile exercise, even when traveling, to improve cardio, coordination, and foot reactivity, which are important for preventing falls.

15. Utilize Bodyweight Exercises

Perform simple bodyweight exercises like pushups, planks, and pull-ups to maintain strength and functional fitness, which are accessible and effective.

16. Focus Training on Cardiac Output

Direct your training efforts towards improving cardiac output (heart rate multiplied by stroke volume), as it is the primary physiological driver of oxygen delivery and overall VO2 max.

17. Use RPE for Easy Days

On easy training days and for general physical activity, rely on your Rating of Perceived Exertion (RPE) rather than strictly tracking metrics like heart rate recovery or variability, focusing on the overall feeling of effort and recovery.

18. Ensure Exercise Accountability

Implement strategies for accountability in your exercise regimen, such as training with a partner, using a device, keeping a diary, or simply tracking your progress, to maintain consistency and motivation.

19. Example Hard Day Workout

For a hard day, perform a circuit of strength exercises (e.g., 25 squat thrusts, 1 minute jump rope, static wall sit to failure, drop sets for major muscle groups) followed by intense cycling intervals (e.g., 8x3-minute ladders with increasing watts, no rest between ladder steps).

20. Example Easy Day Workout

For an easy day, engage in 30-40 minutes of light cycling or rowing, focusing on active rest to promote recovery and loosen muscles, rather than aiming for a significant training effect.

21. Target 30-31 VO2 Max in 80s

Set a specific long-term goal to maintain a VO2 max of 30-31 mL/kg/min into your 80s, which is a level that ensures you can perform virtually any reasonable activity without limitation.

22. Consider Poly Pill if Unable to Exercise

For individuals who are unwilling or unable to exercise, consider a ‘poly pill’ strategy (e.g., low-dose statins, blood pressure medications, metformin) as a potential public health approach to reduce risk factors, though exercise remains the preferred method.

23. Donate Convalescent Plasma

If you have recovered from COVID-19 (especially if vaccinated and had a breakthrough infection), consider donating convalescent plasma within 2-3 weeks of recovery (and up to 3-6 months) to help immune-suppressed patients.

24. Support Open Gym Initiatives

Advocate for or participate in a ’national open gym movement’ to provide accessible facilities and opportunities for unstructured play and physical activity for children and communities, addressing the decline in such opportunities.

25. Walk at Lunch in the Workplace

Utilize available spaces in your workplace, such as long hallways, to walk for 30-40 minutes at lunchtime with colleagues. This provides physical activity, social engagement, and can improve productivity.