← The Peter Attia Drive

#20 - Thomas Dayspring, M.D., FACP, FNLA – Part I of V: an introduction to lipidology

Oct 15, 2018 1h 14m 26 insights
<p>In this five-part series, Thomas Dayspring, M.D., FACP, FNLA, a world-renowned expert in lipidology, and one of Peter's most important clinical mentors, shares his wealth of knowledge on the subject of lipids. Part I serves as an introduction to Tom, his work, and an overview of lipid terminology.</p> <p>We discuss:</p> <ul> <li>Tom's recent and remarkable physical transformation [6:30];</li> <li>The moving stories behind Tom's obsessions: firefighting, hockey, and, of course, lipids [20:30];</li> <li>Tom's medical background [39:30];</li> <li>Producing some of the most accessible diagrams on lipids [50:00];</li> <li>What are the different kinds of lipids, what do they do, and how are they transported? [57:15]; and</li> <li>More.</li> </ul> <p> </p> <p> <span> Learn more at <a href="http://www.peterattiamd.com/"><span><u>www.PeterAttiaMD.com</u></span></a></span></p> <p> <span>Connect with Peter on <a href=""> <span> <u>Facebook</u></span></a> | <a href=""> <span> <u>Twitter</u></span></a> | <a href=""> <span> <u>Instagram</u></span></a>.</span></p>
Actionable Insights

1. Implement Modified Intermittent Fasting

Adopt a modified intermittent fasting regimen by consuming 700 calories or less per day with significant carbohydrate restriction for one week each month, as this led to significant weight loss (67 pounds in 11 months) and improved health markers for Dr. Dayspring.

2. Integrate Caloric Restriction to Optimize Metabolic Health

Incorporate caloric restriction for limited periods as a cornerstone of health strategy to powerfully deplete glycogen, reduce insulin, and intermittently turn off nutrient-sensing pathways, counteracting the metabolically destructive effects of constant feeding in modern environments.

3. Cultivate Strong Personal Motivation for Health Changes

Identify and internalize powerful personal motivations, such as the desire for longevity, family, and avoiding future morbidities, as this deep conviction can overcome initial skepticism and lead to sustained adherence to challenging health regimens.

4. Expect Broad Health Improvements from Fasting

Anticipate comprehensive health benefits from consistent modified intermittent fasting, including resolution of chronic orthopedic symptoms, improved mobility, normalization of cardiometabolic biomarkers (e.g., aminase levels), and overall biochemical health.

5. Persevere Through Initial Fasting Hunger

Understand that initial hunger pangs during a multi-day fast (e.g., days two or three) often subside, and with repeated practice, the body can adapt, leading to less hunger in subsequent fasting periods.

6. Seek Professional and Spousal Support for Dietary Changes

Engage with a dietitian for guidance on meal planning and logistics during restrictive diets, and enlist the support of a spouse or family member for meal preparation, as this external support significantly aids adherence.

7. Address Health Morbidities Proactively

Recognize the cumulative impact of aging and existing health morbidities (e.g., obesity, insulin resistance, arthritic issues, fatty liver) as a strong motivator to adopt healthier lifestyle changes for longevity and improved quality of life.

8. Ground Health Decisions in Scientific Plausibility

Base personal health and dietary decisions on scientifically plausible evidence and consider evolutionary genetic ancestry, rather than ad-libbed theories, to ensure effective and sustainable outcomes.

9. Re-evaluate HDL Cholesterol as a Risk Marker

Avoid making judgments about cardiovascular risk or the effectiveness of interventions solely based on high-density lipoprotein (HDL) cholesterol levels, as this metric is now considered grossly oversimplified and potentially misleading, with its primary utility being in calculations like non-HDL cholesterol.

10. Mitigate Cellular Cholesterol Toxicity Through Diet

Be aware that modern diets can lead to cells producing excessive cholesterol, turning it into a toxic molecule that crystallizes and damages cells; focus on dietary choices that support cellular mechanisms for cholesterol efflux to prevent this toxicity.

11. Optimize Phospholipid Intake for Cell Membrane Health

Recognize the critical role of phospholipids, particularly their fatty acid composition, in maintaining cell membrane fluidity, proper protein expression, and overall cellular signaling, which is essential for general health and lipoprotein functionality.

12. Understand Lipoproteins’ True Primary Function

Recognize that the primary purpose of the lipoprotein system is to transport energy (triglycerides/fatty acids) to tissues for ATP production, not primarily to deliver cholesterol, as most cells synthesize their own cholesterol.

13. Commit to Deep Self-Education in Complex Fields

Dedicate significant time (e.g., 10 years of serious reading) to self-educate in complex fields, even if initial comprehension is low, by persistently engaging with available materials until understanding solidifies, driven by a desire to improve professional practice.

14. Utilize Visuals for Learning and Explaining Complex Concepts

Employ graphical illustrations and visual aids to both learn and explain complex scientific or medical concepts, as the human brain processes visual information more effectively than text, enhancing comprehension for diverse audiences.

15. Persist Through Initial Frustration in Learning

When encountering complex and initially confusing information, persist by re-reading and re-engaging with the material multiple times, as initial frustration often gives way to deeper understanding and passion for the subject.

16. Strive for Excellence in Public Speaking and Education

Continuously refine your methods of explaining and illustrating complex topics in public speaking and educational settings to ensure clarity and engagement, as consistent excellence leads to demand and recognition.

17. Share Knowledge Through Regular Case Studies

Consider creating a regular, free newsletter or content series (e.g., weekly email) featuring real-world case discussions to share specialized knowledge, enhance your reputation, and build a dedicated audience.

18. Recognize the Half-Life of Scientific Facts

Be aware that scientific facts and understanding evolve over time, and information that was considered accurate in the past may now be outdated or incorrect, necessitating continuous learning and critical evaluation.

19. Leverage Third-Party Expertise for Family Health Interventions

When attempting to influence family members to adopt health protocols, especially if they are resistant to direct recommendations, leverage trusted third-party experts (e.g., dietitians, respected mentors) to provide guidance and encouragement.

20. Introduce Children to Passions Early

Expose children to personal passions and interests from a very young age (e.g., placing a hockey stick in a crib) to encourage early imprinting and potentially foster lifelong engagement and skill development.

21. Self-Teach New Physical Skills

Embrace the process of self-teaching new physical skills, such as ice skating and hockey, by starting with basic equipment and consistent practice, even if beginning later in life without formal instruction.

22. Value and Support Mentors for Long-Term Impact

Recognize the profound impact mentors can have on personal and professional development, and actively support their well-being and longevity to continue benefiting from their knowledge and guidance.

23. Follow Dr. Dayspring on Twitter

Follow Dr. Tom Dayspring on Twitter at @DrLipid (D-R-L-I-P-I-D) to access his insights and graphics on lipidology.

24. Utilize Corrected Transcripts

Access the editorialized and corrected versions of podcast transcripts in the show notes to thoroughly understand technical information, as they are meticulously reviewed for accuracy.

25. Access Podcast Information

Visit peteratiyahmd.com to find more information on current and past episodes and other related topics.

26. Explore Niche Historical Interests

If interested in historical firefighting, visit PattersonFireHistory.com to explore a vast collection of documented data, photographs, and the history of firefighting in the United States.