<p><span style="color: #000000;">In this "Ask Me Anything" (AMA) episode, Peter and Bob discuss all things related to GLP-1 agonists—a class of drugs that are gaining popularity for the treatment of obesity. They cover the discovery of these peptides, their physiology, and what it is they do in their natural state. Next, Peter and Bob break down a recently published study which showed remarkable results for weight loss and other metabolic parameters using a once-weekly injection of the GLP-1 agonist drug semaglutide, also known as Ozempic, in overweight and obese patients. Finally, they compare results from the semaglutide study to results from various lifestyle interventions and give their take on the potential future of GLP-1 agonists.</span><span style="color: #333333;"><br /> <br /></span><span style="color: #000000;">If you're not a subscriber and listening on a podcast player, you'll only be able to hear a preview of the AMA. If you're a subscriber, you can now listen to this full episode on your <a href="https://peterattiamd.com/members/private-podcast-feed/">private RSS feed</a> or on our website at the <a href="https://peterattiamd.com/ama29/">AMA #29 show notes page</a>. If you are not a subscriber, you can learn more about the subscriber benefits <a href="https://peterattiamd.com/subscribe/">here</a>.</span><span style="color: #333333;"><br /> <br /></span><span style="color: #000000;">We discuss:</span><span style="color: #333333;"><br /></span></p> <ul> <li><span style="color: #000000;">Remarkable results of a recent study in overweight adults [2:15];</span><span style="color: #333333;"><br /></span></li> <li><span style="color: #000000;">Key background on insulin, glucagon and the incretin effect [4:00];</span><span style="color: #333333;"><br /></span></li> <li><span style="color: #000000;">What is GLP-1 and how does it work? [16:30];</span><span style="color: #333333;"><br /></span></li> <li><span style="color: #000000;">2021 semaglutide study: remarkable results, side effects, and open questions [30:00];</span><span style="color: #333333;"><br /></span></li> <li><span style="color: #000000;">Semaglutide vs. lifestyle interventions: comparing results with semaglutide vs. lifestyle interventions alone [44:00];</span><span style="color: #333333;"><br /></span></li> <li><span style="color: #000000;">Closing thoughts and open questions on the therapeutic potential of semaglutide [47:30]; and</span><span style="color: #333333;"><br /></span></li> <li><span style="color: #000000;">More</span></li> </ul> <div>Learn more: <a href="https://peterattiamd.com/">https://peterattiamd.com/</a><br /> Show notes page for this episode: <a href="https://peterattiamd.com/ama29/">https://peterattiamd.com/ama29/</a> <br /> Subscribe to receive exclusive subscriber-only content: <a href="https://peterattiamd.com/subscribe/">https://peterattiamd.com/subscribe/</a><br /> Sign up to receive Peter's email newsletter: <a href="https://peterattiamd.com/newsletter/">https://peterattiamd.com/newsletter/</a><br /> Connect with Peter on Facebook | Twitter | Instagram.</div>
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