2026
#381 ‒ Alzheimer's disease in women: how hormonal transitions impact the female brain, the role of HRT, genetics, and lifestyle on risk, and emerging diagnostics and therapies | Lisa Mosconi, Ph.D.
#380 ‒ The seed oil debate: are they uniquely harmful relative to other dietary fats? | Layne Norton, Ph.D.
#379 - AMA #79: A guide to cardiorespiratory training at any fitness level to improve healthspan, lifespan, and long-term independence
#378 ‒ Women's health and performance: how training, nutrition, and hormones interact across life stages | Abbie Smith-Ryan, Ph.D.
2025
Building & Changing Habits | James Clear (#183 rebroadcast)
#377 ‒ Special episode: Understanding true happiness and the tools to cultivate a meaningful life—insights from past interviews with Arthur Brooks
#376 - AMA #78: Longevity interventions, exercise, diagnostic screening, and managing high apoB, hypertension, metabolic health, and more
#375 - Ketogenic diet, ketosis & hyperbaric oxygen: metabolic therapies for weight loss, cognition, Alzheimer's & more | Dom D'Agostino, Ph.D.
#374 - The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences, | Carole Hooven, Ph.D.
The impact of gratitude, serving others, embracing mortality, and living intentionally | Walter Green (#288 rebroadcast)
#373 – Thyroid function and hypothyroidism: why current diagnosis and treatment fall short for many, and how new approaches are transforming care | Antonio Bianco, M.D., Ph.D.
#372 - AMA #77: Dietary fiber and health outcomes: real benefits, overhyped claims, and practical applications
#371 – Women's sexual health: desire, arousal, and orgasms, navigating perimenopause, and enhancing satisfaction | Sally Greenwald, M.D., M.P.H.
Longevity 101: a foundational guide to Peter's frameworks for longevity, and understanding CVD, cancer, neurodegenerative disease, nutrition, exercise, sleep, and more (re-broadcast)
#370 - AMA #76: Peter evaluates longevity drugs, aspirin for CVD, and strategies to improve muscle mass — proven, promising, fuzzy, noise, or nonsense?
#369 ‒ Rethinking protein needs for performance, muscle preservation, and longevity, and the mental and physical benefits of creatine supplementation and sauna use | Rhonda Patrick, Ph.D.
#368 ‒ The protein debate: optimal intake, limitations of the RDA, whether high-protein intake is harmful, and how to think about processed foods | David Allison, Ph.D.
#367 - Tylenol, pregnancy, and autism: What recent studies show and how to interpret the data
#366 ‒ Transforming education with AI and an individualized, mastery-based education model | Joe Liemandt
#365 ‒ Training for longevity: A roundtable on building strength, preventing injury, meeting protein needs, guidance for women and youth athletes, and more | Gabrielle Lyon, Mike Boyle, Jeff Cavaliere
#364 – AMA #75: Diets: how to evaluate and implement any diet including keto, carnivore, vegan, Mediterranean, and more
#363 ‒ A new frontier in neurosurgery: restoring brain function with brain-computer interfaces, advancing glioblastoma care, and new hope for devastating brain diseases | Edward Chang, M.D.
Lower back pain: causes, treatment, and prevention of lower back injuries and pain | Stuart McGill, Ph.D. (#287 rebroadcast)
#361 - AMA #74: Sugar and sugar substitutes: weight control, metabolic effects, and health trade-offs
#360 ‒ How to change your habits: why they form and how to build or break them | Charles Duhigg, M.B.A
#359 ‒ How metabolic and immune system dysfunction drive the aging process, the role of NAD, promising interventions, aging clocks, and more | Eric Verdin, M.D.
#358 ‒ Peter's takeaways on navigating HRT, rejuvenating the face, understanding the biology of aging, optimizing fertility, and learning to live well from the dying | Quarterly Podcast Summary #6
#357 ‒ A new era of longevity science: models of aging, human trials of rapamycin, biological clocks, promising compounds, and lifestyle interventions | Brian Kennedy, Ph.D.
#356 - AMA #73: Preserving brain health, optimizing exercise programming, improving body composition, and more
Navigating bone health: early life influences and advanced strategies for improvement and injury prevention (#214 rebroadcast)
#355 – Skincare strategies, the science of facial aging, and cosmetic-intervention guidance | Tanuj Nakra, M.D. & Suzan Obagi, M.D.
#354 – What the dying can teach us about living well: lessons on life and reflections on mortality | BJ Miller, M.D. and Bridget Sumser, L.C.S.W.
#353 - AMA #72: Fasting: benefits for body composition and disease prevention, potential risks, and Peter's updated practical framework
#352 ‒ Female fertility: optimizing reproductive health, diagnosing and treating infertility and PCOS, and understanding the IVF process | Paula Amato, M.D.
#351 ‒ Male fertility: optimizing reproductive health, diagnosing and treating infertility, and navigating testosterone replacement therapy | Paul Turek, M.D.
#350 ‒ Injury prevention, recovery, and performance optimization for every decade | Kyler Brown, D.C.
#349 - AMA #71: Building strength and muscle mass: how to optimize training, nutrition, and more for longevity
#348 ‒ Women's sexual health, menopause, and hormone replacement therapy (HRT) | Rachel Rubin, M.D.
#347 – Peter's takeaways on mastering sleep, dealing with chronic pain, developing breakthrough cancer drugs, transforming healthcare with AI, advancing radiation therapy, and healing trauma | Quarterly Podcast Summary #5
#346 - Scaling biotech and improving global health: lessons from an extraordinary career in medicine | Susan Desmond-Hellmann, M.D., M.P.H.
#345 ‒ Chronic pain: pathways, treatment, and the path to physical and psychological recovery | Sean Mackey, M.D., Ph.D.
#344 - AMA #70: Nicotine: impact on cognitive function, performance, and mood, health risks, delivery modalities, and smoking cessation strategies
#343 – The evolving role of radiation: advancements in cancer treatment, emerging low-dose treatments for arthritis, tendonitis, and injuries, and addressing misconceptions | Sanjay Mehta, M.D.
#342 ‒ Aging well: Peter shares strategies for improving longevity with residents at a senior living center
#341 - Overcoming insomnia: improving sleep hygiene and treating disordered sleep with cognitive behavioral therapy for insomnia | Ashley Mason, Ph.D.
#340 - AMA #69: Scrutinizing supplements: creatine, fish oil, vitamin D, and more—a framework for understanding effectiveness, quality, and individual need
#339 - Unpacking trauma: How early wounds shape behavior and the path toward healing | Jeff English
#338 ‒ Peter's takeaways on aerobic exercise and VO2 max, insulin resistance, rising healthcare costs, treating children with autism and ADHD, and strength training | Quarterly Podcast Summary #4
#337 - Insulin resistance masterclass: The full body impact of metabolic dysfunction and prevention, diagnosis, and treatment | Ralph DeFronzo, M.D.
#336 - AMA #68: Fasting, well-balanced diets, alcohol, exercise for busy people, wearables, emotional health, assessing cardiovascular health, and more
#335 ‒ The science of resistance training, building muscle, and anabolic steroid use in bodybuilding | Mike Israetel, Ph.D.
#334 - Cardiovascular disease, the number one killer: development, biomarkers, apoB, cholesterol, brain health, and more | Tom Dayspring, M.D.
#333 ‒ Longevity roundtable — the science of aging, geroprotective molecules, lifestyle interventions, challenges in research, and more | Steven Austad, Matt Kaeberlein, Richard Miller
#332 - AMA #67: Microplastics, PFAS, and phthalates: understanding health risks and a framework for minimizing exposure and mitigating risk
#331 ‒ Optimizing endurance performance: metrics, nutrition, lactate, and more insights from elite performers | Olav Aleksander Bu (Pt. 2)
#330 – Autism, ADHD, and Anxiety: Understanding the rise in autism and a multidisciplinary approach to diagnosis and treatment of each condition in children | Trenna Sutcliffe, M.D.
2024
Building & Changing Habits | James Clear (#183 rebroadcast)
#329 ‒ Special AMA: Peter on exercise, important labs, building good habits, promising longevity research, and more
#328 - AMA #66: Optimizing nutrition for health and longevity: myth of a "best" diet, complexities of nutrition science, and practical steps for building a sustainable diet
#327 - Choices, costs, and challenges in US healthcare: insurance intricacies, drug pricing, economic impacts, and potential reforms | Saum Sutaria, M.D.
Optimizing life for maximum fulfillment | Bill Perkins (#237 rebroadcast)
#326 - AMA #65: Red light therapy: promising applications, mixed evidence, and impact on health and aging
#325 ‒ Peter's key takeaways on bone health, calorie restriction and energy balance, dopamine and addiction, gene editing, and testosterone therapy safety with a prostate cancer diagnosis | Quarterly Podcast Summary #3
#324 ‒ Metabolism, energy balance, and aging: How diet, calorie restriction, and macronutrients influence longevity and metabolic health | Eric Ravussin, Ph.D.
#323 - CRISPR and the future of gene editing: scientific advances, genetic therapies, disease treatment potential, and ethical considerations | Feng Zhang, Ph.D.
#322 - Bone health for life: building strong bones, preventing age-related loss, and reversing osteoporosis with evidence-based exercise | Belinda Beck, Ph.D.
#321 – Dopamine and addiction: navigating pleasure, pain, and the path to recovery | Anna Lembke, M.D.
#320 – AMA 64: New insights on GLP-1 agonists (Ozempic, Wegovy, Mounjaro) - efficacy, benefits, risks, and considerations in the rapidly evolving weight-loss drug landscape
#319 ‒ Peter's key takeaways on liver health, heart rate variability, AI in medicine, klotho, and lactate metabolism | Quarterly Podcast Summary #2
#318 ‒ Cycling phenom and Tour de France champion Tadej Pogačar reveals his training strategies, on-bike nutrition, and future aspirations
#317 ‒ Reforming medicine: uncovering blind spots, challenging the norm, and embracing innovation | Marty Makary, M.D., M.P.H.
#316 - AMA #63: A guide for hair loss: causes, treatments, transplants, and sex-specific considerations
Improve your decision-making, frameworks for learning, backcasting, and more | Annie Duke (#60 rebroadcast)
#315 ‒ Life after near-death: a new perspective on living, dying, and the afterlife | Sebastian Junger
#314 ‒ Rethinking nutrition science: the evolving landscape of obesity treatment, GLP-1 agonists, protein, and the need for higher research standards | David Allison, Ph.D.
#313 - AMA #62: Protein's impact on appetite and weight management, and uric acid's link to disease and how to manage levels
#312 - A masterclass in lactate: Its critical role as metabolic fuel, implications for diseases, and therapeutic potential from cancer to brain health and beyond | George A. Brooks, Ph.D.
#311 ‒ Longevity 101: a foundational guide to Peter's frameworks for longevity, and understanding CVD, cancer, neurodegenerative disease, nutrition, exercise, sleep, and more
#310 - The relationship between testosterone and prostate cancer, testosterone replacement therapy, and tools for predicting cancer aggressiveness and guiding therapy | Ted Schaeffer, M.D., Ph.D.
#309 ‒ AI in medicine: its potential to revolutionize disease prediction, diagnosis, and outcomes, causes for concern in medicine and beyond, and more | Isaac Kohane, M.D., Ph.D.
Zone 2 training: impact on longevity and mitochondrial function, how to dose frequency and duration, and more | Iñigo San-Millán, Ph.D. (#201 rebroadcast)
#308 - AMA #61: Sun exposure, sunscreen, and skin health: relationship between sun exposure and skin cancer, vitamin D production, and photoaging, how to choose a sunscreen, and more
#307 ‒ Exercise for aging people: where to begin, and how to minimize risk while maximizing potential | Peter Attia, M.D.
#306 - AMA #60: preventing cognitive decline, nutrition myths, lowering blood glucose, apoB, and blood pressure, and more
#305 ‒ Heart rate variability: how to measure, interpret, and utilize HRV for training and health optimization | Joel Jamieson
#304 – NEW: Introducing quarterly podcast summaries - Peter shares his biggest takeaways on muscle protein synthesis, VO2 max, toe strength, gut health, and more
#303 - A breakthrough in Alzheimer's disease: the promising potential of klotho for brain health, cognitive decline, and as a therapeutic tool for Alzheimer's disease | Dena Dubal, M.D., Ph.D.
#302 - Confronting a metabolic epidemic: understanding liver health and how to prevent, diagnose, and manage liver disease | Julia Wattacheril, M.D., M.P.H.
#301 - AMA #59: Inflammation: its impact on aging and disease risk, and how to identify, prevent, and reduce it
#300 - Special episode: Peter on exercise, fasting, nutrition, stem cells, geroprotective drugs, and more — promising interventions or just noise?
Special episode with Dax Shepard: F1 and the 30th anniversary of Ayrton Senna's death
#299 ‒ Optimizing muscle protein synthesis: the crucial impact of protein quality and quantity, and the key role of resistance training | Luc van Loon, Ph.D.
#298 ‒ The impact of emotional health on longevity, self-audit strategies, improving well-being, and more | Paul Conti, M.D.
#297 - AMA #58: Iron: its role in health, testing methods, and strategies for preventing and managing iron deficiency
#296 ‒ Foot health: preventing and treating common injuries, enhancing strength and mobility, picking footwear, and more | Courtney Conley, D.C.
#295 ‒ Roadway death and injury: why everyone should care and what you can do to reduce risk | Mark Rosekind, Ph.D.
#294 ‒ Peak athletic performance: How to measure it and how to train for it from the coach of the most elite athletes on earth | Olav Aleksander Bu
#293 - AMA #57: High-intensity interval training: benefits, risks, protocols, and impact on longevity
#292 ‒ Rucking: benefits, gear, FAQs, and the journey from Special Forces to founding GORUCK | Jason McCarthy
#291 ‒ The role of testosterone in males and females, performance-enhancing drugs, sustainable fat loss, supplements, and more | Derek, More Plates More Dates Pt.2
#290 ‒ Liquid biopsies for early cancer detection, the role of epigenetics in aging, and the future of aging research | Alex Aravanis, M.D., Ph.D.
#289 - AMA #56: Cancer screening: pros and cons, screening options, interpreting results, and more
#288 ‒ The impact of gratitude, serving others, embracing mortality, and living intentionally | Walter Green
#287 ‒ Lower back pain: causes, treatment, and prevention of lower back injuries and pain | Stuart McGill, Ph.D.
#286 ‒ Journal club with Andrew Huberman: the impact of light exposure on mental health and an immunotherapy breakthrough for cancer treatment
#285 - AMA #55: Exercise: longevity-focused training, goal setting, improving deficiencies, managing emotional stress, and more
#284 ‒ Overcoming addictive behaviors, elevating wellbeing, thriving in an era of excess, and the scarcity loop | Michael Easter, M.A.
James Clear: Building & Changing Habits (#183 rebroadcast)
2023
#283 ‒ Gut health & the microbiome: improving and maintaining the microbiome, probiotics, prebiotics, innovative treatments, and more | Colleen Cutcliffe, Ph.D.
#282 - AMA #54: Magnesium: risks of deficiency, how to correct it, supplement options, potential cognitive and sleep benefits, and more
#281 ‒ Longevity drugs, aging biomarkers, and updated findings from the Interventions Testing Program (ITP) | Rich Miller, M.D., Ph.D.
#280 ‒ Cultivating happiness, emotional self-management, and more | Arthur Brooks Ph.D.
The world's most important doctor to millions in the war-torn and remote villages of Sudan | Tom Catena, M.D. (#40 rebroadcast)
#279 - AMA #53: Metabolic health & pharmacologic interventions: SGLT-2 inhibitors, metformin, GLP-1 agonists, and the impact of statins
#278 ‒ Breast cancer: how to catch, treat, and survive breast cancer | Harold Burstein, M.D., Ph.D.
#277 ‒ Food allergies: causes, prevention, and treatment with immunotherapy | Kari Nadeau, M.D., Ph.D.
#276 ‒ Special episode: Peter answers questions on longevity, supplements, protein, fasting, apoB, statins, and more
#275 - AMA #52: Hormone replacement therapy: practical applications and the role of compounding pharmacies
#274 - Performance-enhancing drugs and hormones: risks, rewards, and broader implications for the public | Derek: More Plates, More Dates
#273 ‒ Prostate health: common problems, cancer prevention, screening, treatment, and more | Ted Schaeffer, M.D., Ph.D.
#272 ‒ Rapamycin: potential longevity benefits, surge in popularity, unanswered questions, and more | David Sabatini, M.D., Ph.D. and Matt Kaeberlein, Ph.D.
#271 - AMA #51: Understanding and improving your metabolic health
#270 ‒ Journal club with Andrew Huberman: metformin as a geroprotective drug, the power of belief, and how to read scientific papers
#269 - Good vs. bad science: how to read and understand scientific studies
#268 ‒ Genetics: testing, therapy, editing, association with disease risk, autism, and more | Wendy Chung, M.D., Ph.D.
#267 ‒ The latest in cancer therapeutics, diagnostics, and early detection | Keith Flaherty, M.D.
#266 - AMA #50: Genetics: how they impact disease risk, what you can do about it, testing, and more
#265 - Time, productivity, and purpose: insights from Four Thousand Weeks | Oliver Burkeman
#264 ‒ Hip, knee, ankle, and foot: common injuries, prevention, and treatment options
#263 ‒ Concussions and head trauma: symptoms, treatment, and recovery | Micky Collins, Ph.D.
#262 - AMA #49: Heart rate recovery, strength training, rucking, kidney function, and brain health
#261 ‒ Training for The Centenarian Decathlon: zone 2, VO2 max, stability, and strength | Peter Attia, M.D.
Cancer screening with full-body MRI scans and a seminar on the field of radiology | Rajpaul Attariwala, M.D., Ph.D. (#61 rebroadcast)
#260 ‒ Men's Sexual Health: why it matters, what can go wrong, and how to fix it | Mohit Khera, M.D., M.B.A., M.P.H.
#259 - Women's sexual health: Why it matters, what can go wrong, and how to fix it | Sharon Parish, M.D.
#258 - AMA #48: Blood pressure—how to measure, manage, and treat high blood pressure
#257 ‒ Cognitive decline, neurodegeneration, and head injuries: mitigation and prevention strategies, supplements, and more | Tommy Wood, M.D., Ph.D.
#256 ‒ The endocrine system: exploring thyroid, adrenal, and sex hormones | Peter Attia, M.D.
#255 ‒ Latest therapeutics in CVD, APOE's role in Alzheimer's disease and CVD, familial hypercholesterolemia, and more | John Kastelein, M.D., Ph.D.
#254 - AMA #47: Cold therapy: pros, cons, and its impact on longevity
#253 ‒ Hormone replacement therapy and the Women's Health Initiative: re-examining the results, the link to breast cancer, and weighing the risk vs reward of HRT | JoAnn Manson, M.D.
#252 ‒ Latest insights on Alzheimer's disease, cancer, exercise, nutrition, and fasting | Rhonda Patrick, Ph.D.
The impact of stress on our physical and emotional health | Robert Sapolsky, Ph.D. (#51 rebroadcast)
#251 - AMA #46: Optimizing brain health: Alzheimer's disease risk factors, APOE, prevention strategies, and more
#250 ‒ Training principles for longevity | Andy Galpin, Ph.D. (PART II)
#249 ‒ How the brain works, Andrew's fascinating backstory, improving scientific literacy, and more | Andrew Huberman, Ph.D.
#248 ‒ OUTLIVE book: A behind-the-scenes look into the writing of this book, motivation, main themes, and more
#247 ‒ Preventing cardiovascular disease: the latest in diagnostic imaging, blood pressure, metabolic health, and more | Ethan Weiss, M.D.
#246 - AMA #45: Pros and cons of GLP-1 weight loss drugs and metformin as a geroprotective agent
#245 ‒ Overcoming trauma, finding inner peace, and living a meaningful and fulfilling life | Lewis Howes
#244 ‒ The history of the cell, cell therapy, gene therapy, and more | Siddhartha Mukherjee
#243 ‒ The fentanyl crisis and why everyone should be paying attention | Anthony Hipolito
#242 - AMA #44: Peter's historical changes in body composition with his evolving dietary, fasting, and training protocols
#241 ‒ Living intentionally, valuing time, prioritizing relationships, and more keys to a rich life | Ric Elias (Part 2)
#240 ‒ The confusion around HDL and its link to cardiovascular disease | Dan Rader, M.D.
#239 ‒ The science of strength, muscle, and training for longevity | Andy Galpin, Ph.D. (PART I)
#238 – AMA #43: Understanding apoB, LDL-C, Lp(a), and insulin as risk factors for cardiovascular disease
#237 ‒ Optimizing life for maximum fulfillment | Bill Perkins
2022
James Clear: Building & Changing Habits (#183 rebroadcast)
#235 ‒ Training principles for mass and strength, changing views on nutrition, creatine supplementation, and more | Layne Norton, Ph.D.
#234 ‒ Chris Hemsworth on Limitless, longevity, and happiness
#233 - AMA #42: Optimizing sleep - bedtime routine, molecule regimen, sleep trackers, sauna, & more
#232 ‒ Shoulder, elbow, wrist, and hand: diagnosis, treatment, and surgery of the upper extremities | Alton Barron, M.D.
A masterclass on insulin resistance—mechanisms and implications | Gerald Shulman, M.D., Ph.D. (#140 rebroadcast)
#231 - AMA #41: Medicine 3.0, developments in the field of aging, healthy habits in times of stress, and more
#230 ‒ Cardiovascular disease in women: prevention, risk factors, lipids, and more | Erin Michos, M.D.
#229 ‒ Understanding cardiovascular disease risk, cholesterol, and apoB
#228 ‒ Improving body composition, female-specific training principles, and overcoming an eating disorder | Holly Baxter, APD
#227 - AMA #40: Body composition, protein, time-restricted feeding, fasting, DEXA scans, and more
#226 ‒ The science of happiness | Arthur Brooks, Ph.D.
#225 ‒ The comfort crisis, doing hard things, rucking, and more | Michael Easter, MA
#224 ‒ Dietary protein: amount needed, ideal timing, quality, and more | Don Layman, Ph.D.
#223 - AMA #39: The Centenarian Decathlon, zone 2, VO2 max, and more
#222 ‒ How nutrition impacts longevity | Matt Kaeberlein, Ph.D
#221 ‒ Understanding sleep and how to improve it
#220 ‒ Ketamine: Benefits, risks, and promising therapeutic potential | Celia Morgan, Ph.D.
#219 ‒ Dialectical behavior therapy (DBT): skills for overcoming depression , emotional dysregulation, and more | Shireen Rizvi, Ph.D., ABPP
#218 - AMA #38: Can you exercise too much?
#217 ‒ Exercise, VO2 max, and longevity | Mike Joyner, M.D.
#216 - Metabolomics, NAD+, and cancer metabolism | Josh Rabinowitz, M.D., Ph.D.
#215 - The gut-brain connection | Michael Gershon, M.D.
#214 - AMA #37: Bone health—everything you need to know
#213 ‒ Liquid biopsies and cancer detection | Max Diehn, M.D. Ph.D.
Earning the gift of life | Ric Elias (#79 rebroadcast)
#212 - The neuroscience of obesity | Stephan Guyenet, Ph.D.
#211 - AMA #36: Fruits & vegetables—everything you need to know
#210 - Lp(a) and its impact on heart disease | Benoît Arsenault, Ph.D.
#209 ‒ Medical mistakes, patient safety, and the RaDonda Vaught case | Marty Makary, M.D., M.P.H.
#208 - Tragedy, grief, healing, and finding happiness | Kelsey Chittick
#207 - AMA #35: "Anti-Aging" Drugs — NAD+, metformin, & rapamycin
#206 - Exercising for longevity: strength, stability, zone 2, zone 5, and more
#205 - Energy balance, nutrition, & building muscle | Layne Norton, Ph.D. (Pt.2)
#204 - Centenarians, metformin, and longevity | Nir Barzilai, M.D.
#203 - AMA #34: What Causes Heart Disease?
#202 - Peter on nutrition, disease prevention, sleep, and more — looking back on the last 100 episodes
In remembrance of Sarah Hallberg, D.O., M.S. (Ep. #162 Rebroadcast)
#201 - Deep dive back into Zone 2 | Iñigo San-Millán, Ph.D. (Pt. 2)
#200 - AMA #33: Hydration—electrolytes, supplements, sports drinks, performance effects, and more
#199 - Running, overcoming challenges, and finding success | Ryan Hall
#198 - Eye health—everything you need to know | Steven Dell, M.D.
#197 - The science of obesity & how to improve nutritional epidemiology | David Allison, Ph.D.
#196 - AMA #32: Exercise, squats, deadlifts, BFR, and TRT
#195 - Freedom, PTSD, war, and life through an evolutionary lens | Sebastian Junger
#194 - How fructose drives metabolic disease | Rick Johnson, M.D.
#193 - AMA #31: Heart rate variability (HRV), alcohol, sleep, and more
#192 - COVID Part 2: Masks, long COVID, boosters, mandates, treatments, and more
#191 - Revolutionizing our understanding of mental illness with optogenetics | Karl Deisseroth M.D., Ph.D.
#190 - Paul Conti, M.D.: How to heal from trauma and break the cycle of shame
#189 - COVID-19: Current state of affairs, Omicron, and a search for the end game
2021
Iñigo San Millán, Ph.D.: Zone 2 Training and Metabolic Health (Ep. #85 Rebroadcast)
#188 - AMA #30: How to Read and Understand Scientific Studies
#187 - Sam Apple: The Warburg Effect—Otto Warburg's cancer metabolism theory
#186 - Patrick Radden Keefe: The opioid crisis—origin, guilty parties, and the difficult path forward
#185 - Allan Sniderman, M.D.: Cardiovascular disease and why we should change the way we assess risk
Rick Johnson, M.D.: Metabolic Effects of Fructose (Ep. #87 Rebroadcast)
#184 - AMA #29: GLP-1 Agonists—The Future of Treating Obesity?
#183 - James Clear: Building & changing habits
#182 - David Nutt: Psychedelics & Recreational Drugs
#181 - Robert Gatenby, M.D.: Viewing cancer through an evolutionary lens and why this offers a radically different approach to treatment
#180 - AMA #28: All things testosterone and testosterone replacement therapy
#179 - Jeremy Loenneke, Ph.D.: The science of blood flow restriction—benefits, uses, and what it teaches us about the relationship between muscle size and strength
#178 - Lance Armstrong: The rise, fall, and growth of a cycling legend
#177 - Steven Rosenberg, M.D., Ph.D.: The development of cancer immunotherapy and its promise for treating advanced cancers
#176 - AMA #27: The importance of muscle mass, strength, and cardiorespiratory fitness for longevity
#175 - Matt Kaeberlein, Ph.D.: The biology of aging, rapamycin, and other interventions that target the aging process
#174 - Lawrence Wright: The 20th anniversary of the 9/11 attacks: reflections on how they happened, and lessons learned and not learned
#173 - AMA #26: Continuous glucose monitors, zone 2 training, and a framework for interventions
#172 - Esther Perel: The effects of trauma, the role of narratives in shaping our worldview, and why we need to accept uncomfortable emotions
#171 - Steve Austad, Ph.D.: The landscape of longevity science: making sense of caloric restriction, biomarkers of aging, and possible geroprotective molecules
#170 - AMA #25: Navigating the complexities and nuances of cancer screening
#169 - Katherine Eban: COVID-19 Lab Leak: Examining all sides of the debate and discussing barriers to a full investigation
#168 - Hugh Jackman: Reflections on acting, identity, personal transformation, and the significance of being Wolverine
#167 - Gary Taubes: Bad science and challenging the conventional wisdom of obesity
#166 - Patricia Corby, D.D.S.: Importance of oral health, best hygiene practices, and the relationship between poor oral health and systemic disease
#165 - AMA #24: Deep dive into blood glucose: why it matters, important metrics to track, and superior insights from a CGM
#164 - Amanda Smith, M.D.: Diagnosing, preventing, and treating Alzheimer's disease, and what we can all learn from patients with dementia
#163 - Layne Norton, Ph.D.: Building muscle, losing fat, and the importance of resistance training
#162 - Sarah Hallberg, D.O., M.S.: Challenging the status quo of treating metabolic disease, and a personal journey through a grim cancer diagnosis
#161 - AMA #23: All Things Nicotine: deep dive into its cognitive and physical benefits, risks, and mechanisms of action
#160 - Paul Offit, M.D.: The latest on COVID-19 vaccines and their safety, herd immunity, and viral variants
#159 - Peter Hotez, M.D., Ph.D.: Evolution of the anti-vaccine movement, the causes of autism, and COVID-19 vaccine state of affairs
#158 - Brian Deer: A tale of scientific fraud—exposing Andrew Wakefield and the origin of the belief that vaccines cause autism
#157 - AMA #22: Losing fat and gaining fat: the lessons of fat flux
#156 - Jake Muise: Humanely harvesting axis deer while alleviating its impact on Hawaii's vulnerable ecosystems
#155 - Chris Sonnenday, M.D.: The history, challenges, and gift of organ transplantation
#154 - Steve Levitt, Ph.D.: A rogue economist's view on climate change, mental health, the ethics of experiments, and more
#153 - AMA #21: Deep dive into olive oil, high-intensity exercise, book update, and more
#152 - Michael Rintala, D.C.: Principles of Dynamic Neuromuscular Stabilization (DNS)
#151 - Alex Hutchinson, Ph.D.: Translating the science of endurance and extreme human performance
#150 - Senator Bill Frist, M.D.: A modern Renaissance man's journey through science, politics, and business
#149 - AMA #20: Simplifying the complexities of insulin resistance: how it's measured, how it manifests in the muscle and liver, and what we can do about it
#148 - Richard Miller, M.D., Ph.D.: The gold standard for testing longevity drugs: the Interventions Testing Program
#147 - Hussein Yassine, M.D.: Deep dive into the "Alzheimer's gene" (APOE), brain health, and omega-3s
#146 - Guy Winch, Ph.D.: Emotional first aid and how to treat psychological injuries
#145 - AMA #19: Deep dive on Zone 2 training, magnesium supplementation, and how to engage with your doctor
#144 - Phil Maffetone: Optimizing health and performance through maximal aerobic function
#143 - John Ioannidis, M.D., D.Sc.: Why most biomedical research is flawed, and how to improve it
2020
#142 - Robert Abbott: The Bobby Knight story—a cautionary tale of unchecked anger, ego, and winning at all costs
#141 - AMA #18: Deep dive: sugar and sugar substitutes
#140 - Gerald Shulman, M.D., Ph.D.: A masterclass on insulin resistance—molecular mechanisms and clinical implications
#139 - Kristin Neff, Ph.D.: The power of self-compassion
#138 - Lauren Miller Rogen and Richard Isaacson, M.D.: Alzheimer's disease prevention—patient and doctor perspectives
#137 - Paul Offit, M.D.: An expert perspective on COVID-19 vaccines
#136 - AMA #17: Body composition methods tour de force, insulin resistance, and Topo Chico
#135 - BJ Miller, M.D.: How understanding death leads to a better life
#134 - James O'Keefe, M.D.: Preventing cardiovascular disease and the risk of too much exercise.
#133 - Vinay Prasad, M.D., M.P.H: Hallmarks of successful cancer policy
#132 - AMA #16: Exploring hot and cold therapy
#130 - Carol Tavris, Ph.D. & Elliot Aronson, Ph.D.: Recognizing and overcoming cognitive dissonance
#129 - Tom Dayspring, M.D.: The latest insights into cardiovascular disease and lipidology
#128 – Irene Davis, Ph.D.: The evolution of the foot, running injuries, and minimalist shoes
#127 - AMA #3 with sleep expert, Matthew Walker, Ph.D.: Fasting, gut health, blue light, caffeine, REM sleep, and more
#126 – Matthew Walker, Ph.D.: Sleep and immune function, chronotypes, hygiene tips, and addressing questions about his book
#125 - John Arnold: The most prolific philanthropist you may not have heard of
#124 - AMA #15: Real-world case studies—metabolic dysregulation, low testosterone, menopause, and more
#123 - Joan Mannick, M.D. & Nir Barzilai, M.D.: Rapamycin and metformin—longevity, immune enhancement, and COVID-19
#122 - Lori Gottlieb: Understanding pain, therapeutic breakthroughs, and keys to enduring emotional health
#121 - Azra Raza, M.D.: Why we're losing the war on cancer
#120 - AMA with Dom D'Agostino, Ph.D., Part II of II: Ketosis for cancer and chronic disease, hyperbaric oxygen therapy, and the effect of ketosis on female health
#119 - Terry Real: Breaking the cycle of shame, anger, and depression
#118 - Lloyd Klickstein, M.D., Ph.D.: Rapamycin, mTOR inhibition, and the biology of aging
#117 - Stanley Perlman, M.D., Ph.D.: Insights from a coronavirus expert on COVID-19
#116 - AMA with Dom D'Agostino, Ph.D., Part I of II: Ketogenic diet, exogenous ketones, and exercise
#115 - David Watkins, Ph.D.: A masterclass in immunology, monoclonal antibodies, and vaccine strategies for COVID-19
#114 - Eileen White, Ph.D.: Autophagy, fasting, and promising new cancer therapies
#113: Normative errors—a conversation with my daughter about current events
#112 - Ned David, Ph.D.: How cellular senescence influences aging, and what we can do about it
#111 - AMA #14: What lab tests can (and cannot) inform us about our overall objective of longevity
#110 - Lew Cantley, Ph.D.: Cancer metabolism, cancer therapies, and the discovery of PI3K
#109 - John Dudley: The beauty in archery, the love of practice, and a model system for life
#108 - AMA #13: 3-day fasting, exogenous ketones, autophagy, and exercise for longevity
#107 - John Barry: 1918 Spanish flu pandemic—historical account, parallels to today, and lessons
#106 - Amesh Adalja, M.D.: Comparing COVID-19 to past pandemics, preparing for the future, and reasons for optimism
#105 - Paul Conti, M.D.: The psychological toll of a pandemic, and the societal problems it has highlighted
#104 - COVID-19 for kids with Olivia Attia
#103 - Looking back on the first 99 episodes: Strong Convictions, Loosely Held
#102 - Michael Osterholm, Ph.D.: COVID-19—Lessons learned, challenges ahead, and reasons for optimism and concern
#101 - Ryan Holiday: Finding stillness amidst chaos
#100 - Sam Harris, Ph.D.: COVID-19—Comprehending the crisis and managing our emotions
#99 - Peter Hotez, M.D., Ph.D.: Continuing the conversation on COVID-19
Qualy #129 - Evolutionary reasons to sleep
#97 - Peter Hotez, M.D., Ph.D.: COVID-19: transmissibility, vaccines, risk reduction, and treatment
Qualy #125 - Hierarchies in healthcare, physician burnout, and a broken system
#96 - David Epstein: How a range of experience leads to better performance in a highly specialized world
Qualy #121 - The "art" of longevity: the challenge of preventative medicine and understanding risk
#95 - Luke Bennett, M.D.: The emotional, cognitive, and physical demands that make Formula 1 a unique and special sport
Qualy #120 - What is the difference between ketone salts and esters?
#94 - Mark Hyman, M.D.: The impact of the food system on our health and the environment
Qualy #116 - Dealing with anger in spots where you know it's coming
#93 - AMA with Jason Fried: Work-life balance, avoiding burnout, defining success, company culture, and more
Qualy #109 - How does one select the right physician as a patient?
92 - AMA #12: Strategies for longevity (which don't require a doctor)
Qualy #106 - Does LDL cause heart disease?
#91 – Eric Topol, M.D.: Can AI empower physicians and revolutionize patient care?
Qualy #102 - Is the food industry still saying that all calories contribute equally to adiposity and insulin resistance?
#90 - Ryan Holiday: Stillness, stoicism, and suffering less
Qualy #99 - The steroid controversy: Mark's use of them and Peter's perspective
#89 - AMA #11: All things fasting
Qualy #94 - Comparing the two broad types of meditation, and Peter's favorite meditation apps
Qualy #89 - Cortisol and healthy aging
#87 - Rick Johnson, M.D.: Fructose—The common link in high blood pressure, insulin resistance, T2D, & obesity?
2019
Qualy #85 - The past, present, and future of medicine, hospitals, and healthcare
#86 - Damon Hill: Overcoming loss, achieving success, and finding one's identity
Qualy #82 - What is the most common first presentation of heart disease?
#85 - Iñigo San Millán, Ph.D.: Mitochondria, exercise, and metabolic health
Qualy #80 - The four pillars of charity: water that helped it overcome the stigma of nonprofits and become successful
#84 - AMA #10: Low testosterone, hypothyroidism, building muscle (and preserving it while fasting)
Qualy #73 - How can we change the food system when 10 companies control almost 90 percent of the calories we consume in the US?
#83 - Bill Harris, Ph.D.: Omega-3 fatty acids
Qualy #69 - Advice to parents and kids for creating a sustainable environment that's going to prevent them from running into metabolic problems
#82 - Mark Messier: Leadership, personal growth, and performing under pressure
Qualy #65 - The three laws of medicine — Law #1: A strong intuition is much more powerful than a weak test
#81 - Debra Kimless, M.D. & Steve Goldner, J.D.: Cannabis – the latest science on CBD & THC
Qualy #61 - Rapamycin in cancer treatment
#80 - Celebrity AMA #1: Fasting, rapamycin, performance vs. longevity, and more
Qualy #57 - A primer on NAD+/NADH, its effect on lifespan/healthspan, and a review of the supplements
#79 - Ric Elias: Earning the gift of life
Qualy #53 - Screening for prostate cancer
#78 - Sasha Cohen: The price of achievement, and redefining success
Qualy #52 - Insights about berberine
#77 – AMA #2 with sleep expert, Matthew Walker, Ph.D.: short sleep mutants, optimal sleep environment, sleep apnea, & rapid fire questions
Qualy #46 - Rapamycin's effects on cancer, cardiovascular disease, and neurodegeneration
#76 - Kyle Kingsbury: Finding meaning, depression, and psychedelics
Qualy #43 - What are Peter's thoughts on fasting and ketosis for females?
#75 - David Light: Zantac recall due to cancer concerns – what you need to know
Qualy #38 - Finding meaning in struggle and why we are less happy than ever (David Foster Wallace)
#74 – Jason Fried: Optimizing efficiency and work-life balance
Qualy #33 - How silent bravado and incessant striving can lead to a functional (and actual) death, and why Paul is critical of the current state of psychiatry
#73 - AMA #9: NAD & metformin, fat-burning zone, creatine, estrogenization of men, emergency kit for cold & flu, and more
#72 - Dan Harris: 10% happier – meditation, kindness, and compassion
Qualy #26 - What is Peter looking to achieve and monitor with his blood glucose monitor?
#71 - Katherine Eban: Widespread fraud in the generic drug industry
Qualy #24 - What are the "ABCs" of Alzheimer's prevention?
#70 - David Sinclair, Ph.D.: How cellular reprogramming could slow our aging clock (and the latest research on NAD)
Qualy #19 - A unifying theory of aging
#69 - Ronesh Sinha, M.D.: Insights into the manifestation of metabolic disease in a patient population predisposed to metabolic syndrome, and what it teaches us more broadly
Qualy #16 - How much does cognitive activity ward off cognitive decline?
#68 - Marty Makary, M.D.: The US healthcare system—why it's broken, steps to fix it, and how to protect yourself
Qualy #9 - The importance of exercise for brain health
#67 - AMA #8: DNA tests, longevity genes, metformin, fasting markers, salt, inflammation, and more
Qualy #6 - What are the best lab tests to request specifically for longevity
#66 - Vamsi Mootha, M.D.: Aging, type 2 diabetes, cancer, Alzheimer's disease, and Parkinson's disease – do all roads lead to mitochondria?
Qualy #1 - What are Peter's thoughts on alcohol consumption and health?
#65 - Rick Doblin, Ph.D.: MDMA— the creation, scheduling, toxicity, therapeutic use, and changing public opinion of what is possibly the single most important synthetic molecule ever created by our species
#64 - Zol Kryger, M.D.: Navigating the sometimes shady world of plastic surgery—understanding potential complications of common procedures and how to reduce your risk by choosing the right doctor and asking the right questions
#63 - AMA #7: Exercise framework, deadlifting, lower back pain, blood pressure, nootropics, CGM, and more
#62 - Keith Flaherty, M.D.: Deep dive into cancer—History of oncology, novel approaches to treatment, and the exciting and hopeful future
#61 - Rajpaul Attariwala, M.D., Ph.D.: Cancer screening with full-body MRI scans and a seminar on the field of radiology
The one-year anniversary episode with Olivia Attia: Reflecting on the past year and looking forward to exciting times ahead
#60 - Annie Duke, decision strategist: Poker as a model system for life—how to improve decision making, use frameworks for learning, and apply 'backcasting' to boost your odds for future success
#59 - Jason Fung, M.D.: Fasting as a potent antidote to obesity, insulin resistance, type 2 diabetes, and the many symptoms of metabolic illness
#58 – AMA with sleep expert, Matthew Walker, Ph.D.: Strategies for sleeping more, sleeping better, and avoiding things that are disrupting sleep
#57 – Rick Rubin, legendary music producer: collaborating with sensitive psyche of greatest living musicians, and his personal story of weight loss and spiritual quest
#56 - Jocko Willink, retired Navy SEAL, Part II of II: Sleep, fasting, raising kids, discipline, taking ownership, and the impact of war
#55 - Jocko Willink, retired Navy SEAL, Part I of II: objective, strategy & tactics, leadership, protocols, dealing with death, and applying the many lessons learned from war
#54 – Kevin Sayer, CEO of Dexcom: Continuous glucose monitors – impact of food, sleep, and stress on glucose, the unmatched power of CGM to drive behavioral change, and the exciting future of CGM
#53 - AMA #6: Fasting framework, vitamin supplementation, antioxidants, time management, problem-solving, and more
#52 - Ethan Weiss, M.D.: A masterclass in cardiovascular disease and growth hormone - two topics that are surprising interrelated
The Ayrton Senna Episode (re-release): Celebrating the greatest driver in Formula 1 history and the cautionary tales of driven individuals
#51 - Robert Sapolsky, Ph.D.: The pervasive effect of stress - is it killing you?
#50 - AMA #5: calcium scores, centenarian olympics, exercise, muscle glycogen, keto, and more
#49 – Matthew Walker, Ph.D., on sleep – Part III of III: The penetrating effects of poor sleep from metabolism to performance to genetics, and the impact of caffeine, alcohol, THC, and CBD on sleep
#48 – Matthew Walker, Ph.D., on sleep – Part II of III: Heart disease, cancer, sexual function, and the causes of sleep disruption (and tips to correct it)
#47 – Matthew Walker, Ph.D., on sleep – Part I of III: Dangers of poor sleep, Alzheimer's risk, mental health, memory consolidation, and more.
#46 - Chris Masterjohn, Ph.D.: Navigating the many pathways to health and disease - NAD and sirtuins, methylation, MTHFR and COMT, choline deficiency and NAFLD, TMAO, creatine, and more
#45 - AMA #4: sleep, jet lag protocol, autophagy, metformin, and more
#44 - Jeremy Schaap, ESPN journalist: upsets, doping, triumphs, and the importance of sports
#43 - Alan Bauman, M.D.: The science of male and female hair restoration - how to protect, enhance, and restore the appearance and health of the hair and scalp
#42 - Avrum Bluming, M.D., and Carol Tavris, Ph.D.: Controversial topic affecting all women—the role of hormone replacement therapy through menopause and beyond—the compelling case for long-term HRT and dispelling the myth that it causes breast cancer
#41 - Jake Kushner, M.D.: How to thrive with type 1 diabetes and how everyone can benefit from the valuable insights
#40 - Tom Catena, M.D.: The world's most important doctor – to nearly a million patients – saving countless lives in the war-torn and remote villages of Sudan
#39 - Ted Schaeffer, M.D., Ph.D.: How to catch, treat, and survive prostate cancer
#38 - Francisco Gonzalez-Lima, Ph.D.: Advancing Alzheimer's disease treatment and prevention – is AD actually a vascular and metabolic disease?
#37 - Zubin Damania, M.D.: Revolutionizing healthcare one hilariously inspiring video at a time
#36 - Eric Chehab, M.D.: Extending healthspan and preserving quality of life
#35 - Nir Barzilai, M.D.: How to tame aging
2018
#34 - Sam Harris, Ph.D.: The transformative power of mindfulness
#33 - Rudy Leibel, M.D.: Finding the obesity gene and discovering leptin
#32 - Siddhartha Mukherjee, M.D., Ph.D.: new frontiers in cancer therapy, medicine, and the writing process
#31 - Navdeep Chandel, Ph.D.: metabolism, mitochondria, and metformin in health and disease
#30 - Thomas Seyfried, Ph.D.: Controversial discussion—cancer as a mitochondrial metabolic disease?
#29 - Apolo Anton Ohno: 8-time Olympic medalist – extreme training, discipline, pursuing perfection, and responding to adversity
#28 - Mark and Chris Bell: steroids, powerlifting, addiction, diet, training, helping others, documentaries, and living your best life
#27 - David Sinclair, Ph.D.: Slowing aging – sirtuins, NAD, and the epigenetics of aging
#26 - AMA #3: supplements, women's health, patient care, and more
#25 - Scott Harrison: transformation, finding meaning, and taking on the global water crisis
#24 - Tom Dayspring, M.D., FACP, FNLA – Part V of V: Lp(a), inflammation, oxLDL, remnants, and more
#23 - Tom Dayspring, M.D., FACP, FNLA – Part IV of V: Statins, ezetimibe, PCSK9 inhibitors, niacin, cholesterol and the brain
#22 - Tom Dayspring, M.D., FACP, FNLA – Part III of V: HDL, reverse cholesterol transport, CETP inhibitors, and apolipoproteins
#21 - Tom Dayspring, M.D., FACP, FNLA – Part II of V: Lipid metrics, lipid measurements, and cholesterol regulation
#20 - Thomas Dayspring, M.D., FACP, FNLA – Part I of V: an introduction to lipidology
#19 - Dave Feldman: stress testing the lipid energy model
#18 - Richard Isaacson, M.D.: Alzheimer's prevention
#17 - Mike Trevino: life-lessons from ultra-endurance, mindset, hard work, and removing limitations
#16 - Formula 1 (with Paul Conti): the best drivers, Ayrton Senna, and the cautionary tales of driven individuals
#15 - Paul Conti, M.D.: trauma, suicide, community, and self-compassion
#14 - Robert Lustig, M.D., M.S.L.: fructose, processed food, NAFLD, and changing the food system
#13 - Brett Kotlus, M.D.: How to look younger while you live longer
#12 - Corey McCarthy: Overcoming trauma, dealing with shame, finding meaning, changing the self-narrative, redemption, and the importance of gratitude
#11 - AMA #2: the Nothingburger — results from Peter's week-long fast between two weeks of nutritional ketosis — and answering questions on all things fasting
#10 - Matt Kaeberlein, Ph.D.: rapamycin and dogs — man's best friends? — living longer, healthier lives and turning back the clock on aging, and age-related diseases
#09 - David Sabatini, M.D., Ph.D.: rapamycin and the discovery of mTOR — the nexus of aging and longevity?
#08 - Tom Bilyeu: nutrition, fasting, meditation, mindset, immortality, and the secret formula of fulfillment
#07 - Deep Dive: Lp(a) — what every doctor, and the 10-20% of the population at risk, needs to know
#06 - D.A. Wallach: music, medicine, cancer screening, and disruptive technologies
#05 - Dom D'Agostino, Ph.D.: ketosis, n=1, exogenous ketones, HBOT, seizures, and cancer
#04 - AMA #1: alcohol, best lab tests, wearables, finding the right doc, racing, and more
#03 - Ron Krauss, M.D.: a deep dive into heart disease
#02 - Rhonda Patrick, Ph.D.: the performance and longevity paradox of IGF-1, ketogenic diets and genetics, the health benefits of sauna, NAD+, and more
#01 - Tim Ferriss: depression, psychedelics, and emotional resilience
#00 - Sneak Peek: The Peter Attia Drive