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David Sinclair: Reversing the Aging Process

May 3, 2022 1h 35m 45 insights
Biologist and genetics expert Dr. David Sinclair is out to prove he can live past 100 years old, and he thinks you can too. On this episode Sinclair goes in-depth on the process of aging and the techniques you can incorporate into your life that help you live a longer, healthier life, including optimizing your diet, the benefits of exercise, the role of a positive attitude, the importance of sleep, the three supplements he takes every day, why it’s never too late to slow the process of aging, and so much more.   Dr. Sinclair is a professor of genetics and co-director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, and he is best known for his research on aging, with a focus on epigenetics. He’s been called one of the 100 Most Influential People in the World by Time, and in 2019 he released the New York Times bestselling book, Lifespan: Why We Age – and Why We Don't Have To. -- Want even more? Members get early access, hand-edited transcripts, member-only episodes, and so much more. Learn more here: https://fs.blog/membership/ Every Sunday our Brain Food newsletter shares timeless insights and ideas that you can use at work and home. Add it to your inbox: https://fs.blog/newsletter/ Follow Shane on Twitter at: https://twitter.com/ShaneAParrish
Actionable Insights

1. Take Control of Longevity

Recognize that 80% of your future longevity and health is within your control through lifestyle choices, empowering you to make impactful changes.

2. Act Proactively on Longevity

Don’t wait for a traumatic health event in your life or your family’s to start making changes; begin implementing longevity strategies now.

3. Maintain Long-Term Consistency

Commit to consistent daily efforts over a long period, understanding that longevity benefits accrue gradually and require sustained dedication, not just short-term attempts.

4. Combine Longevity Strategies

Understand that lifestyle interventions (diet, exercise, hot/cold therapy, mental state) and supplements have additive benefits, meaning combining them yields greater results than relying on just one.

5. Consult Doctor Before Changes

Always consult with a physician before making significant dietary or lifestyle changes, especially if you have existing health conditions or specific body weight needs.

6. Mimic Adversity for Longevity

Induce perceived adversity in your body through practices like skipping meals, eating less protein, experiencing hot and cold temperatures, and consuming a Mediterranean-type diet to activate survival pathways and slow the epigenetic clock.

7. Practice 14-Hour Fasting

Fast for at least 14 hours daily to achieve significant health benefits such as improved metabolic stability, lower blood sugar levels, and better cholesterol.

8. Gradually Adopt Fasting

Do not attempt extreme fasting immediately; gradually work up to longer fasting periods and use tricks like drinking water or tea to help manage hunger.

9. Try 16:8 Intermittent Fasting

Skip one meal a day to fast for 16 hours, often by having a late lunch or early dinner, utilizing your sleep period as part of the fasting state.

10. Consider 20-Hour Daily Fasting

Aim for approximately 20 hours of fasting on good days by skipping breakfast and often lunch, which can be a more advanced form of intermittent fasting.

11. Engage in Multi-Day Fasting

Fast for more than three days occasionally (e.g., every few weeks for 3-4 days, or a week-long fast four times a year) to activate beneficial protein recycling known as autophagy.

12. Fasting Benefits Persist

You can still reap the benefits of fasting even if you consume the same total calories within a shorter eating window, as the timing of meals is crucial.

13. Prioritize Plant-Based Foods

Focus mainly on plant-based foods, as they have fewer available amino acids and a ratio that activates survival pathways like mTOR, which is crucial for longevity.

14. Adopt Plant-Based Diets

Follow a Mediterranean, vegetarian, or vegan diet, as these are known to be healthy and conducive to longevity by activating the body’s natural defenses.

15. Pulse Adversity and Abundance

Alternate between periods of dietary adversity (e.g., plant-focused, lower protein) and occasional abundance (e.g., extra protein on workout days) to maximize longevity benefits.

16. Reduce or Eliminate Meat

Progress towards a diet with less or no meat, as this can improve health markers like cholesterol and triglycerides, particularly beneficial for those with a family history of heart disease.

17. Reduce Carbohydrates

Cut down on high carbohydrate foods, particularly bread, as this can lead to immediate improvements in biochemistry levels, especially glucose.

18. Reduce or Eliminate Dairy

Consider reducing or eliminating dairy from your diet, as it has been observed to improve blood biochemistry and overall health markers for some individuals.

19. Eat Carbs After Protein

Consume carbohydrates after eating protein to help prevent blood glucose levels from spiking too high, which is beneficial for metabolic stability.

20. Choose Stressed/Organic Plants

Opt for plants that are stressed (e.g., organic, locally grown, not “pretty”) as they produce more health-promoting molecules that can trick your body into activating longevity defenses.

21. Eat Brightly Colored Produce

Consume brightly colored fruits and vegetables (orange, dark green, red) as their colors indicate the presence of protective and health-promoting chemicals.

22. Consume Organic, In-Season Produce

Prioritize organic and in-season vegetables and fruits, as they are more likely to have the abundance of nutrients and beneficial chemicals desired.

23. Start Day with Matcha Tea

Begin your day with a cup of hot, unsweetened matcha green tea to boost your body’s defenses, provide beneficial molecules, and help suppress hunger, reducing the need for breakfast.

24. Prioritize Sufficient Sleep

Recognize that sufficient sleep is crucial for preventing premature aging and maintaining metabolic health, as sleep deprivation can disrupt the body’s internal clock and lead to health issues like diabetes.

25. Optimize Sleep Temperature

Use a bed or system that can reduce your body temperature during the night to promote deeper and more restorative sleep.

26. Practice Nightly Meditation

Incorporate meditation into your nightly routine most days, as it can be very helpful for improving sleep quality and overall well-being.

27. Incorporate Diverse Exercise

Engage in at least two, preferably three, types of exercise: yoga/Pilates for joint flexibility, weightlifting to maintain muscle mass, and aerobic exercise (losing your breath for 10 minutes, 1-3 times a week).

28. Use Saunas for Heart Health

Regularly use saunas, as there is significant evidence suggesting benefits for heart health, similar to the effects of exercise.

29. Incorporate Cold Exposure

Expose your body to cold temperatures (e.g., cold tubs) to activate brown fat, which can rev up metabolism and secrete signals that promote overall body health.

30. Reduce Chronic Mental Stress

Actively work to reduce chronic psychological stress, depression, and worry, as these states can lead to cortisol surges that are detrimental to health and reduce lifespan.

31. Practice Stress Reduction

Employ techniques such as meditation and breathing exercises to manage and reduce psychological stress and excessive worrying.

32. Focus on Gratitude & Control

Reduce worry by focusing on what you can control in the day and practicing gratitude for basic needs like food, shelter, friends, and family.

33. Cultivate Strong Social Bonds

Seek out and maintain companionship, ideally with a reliable partner or a pet, as strong social connections are a crucial factor in reducing stress levels and promoting longevity.

34. Live with Purpose & Mission

Cultivate a sense of purpose and work towards goals that are bigger than yourself, as this can focus the mind, reduce stress, and is common among long-lived individuals.

35. Prioritize Fall Prevention

Take simple precautions like holding onto handrails, maintaining hip strength, and ensuring a safe household environment to prevent falls, which can be life-threatening for older individuals.

36. Supplement with NMN

Supplement with 1 gram of NMN (nicotinamide mononucleotide) daily to boost NAD levels, which are essential for life and activate sirtuin defenses, helping to restore youthful cellular function.

37. Take Resveratrol with Fat

Take 1 gram of resveratrol daily, mixed with a small amount of yogurt or avocado, to ensure absorption and activate the SIRT1 longevity pathway.

38. Ensure Adequate Nutrition

If following a plant-based diet, use a supplement like Athletic Greens to ensure adequate intake of vitamins and plant-based whole foods, preventing nutrient deficiencies.

39. Consider Metformin

Discuss with your doctor the potential of taking Metformin (1 gram daily, or 2 grams for Type 2 diabetics), a drug associated with longer life and reduced disease in old age.

40. Stage Longevity Interventions

Begin meal skipping in your 20s (ensuring adequate calories) and start supplements like NMN and resveratrol in your late 20s or 30s, as the body’s natural defenses are stronger in youth.

41. Monitor Biological Age

Consider using services like Tally Health (tallyhealth.com) to measure your biological age via a cheek swab, allowing you to track the impact of lifestyle changes and potentially slow or reverse aging.

42. Share Data with Doctors

Proactively collect and share your personal health data from trackers and tests with your doctor, as they are often grateful for the additional insights to inform your care.

43. Add Years with Core Habits

By consistently practicing core longevity habits—eating healthy (not too much), getting enough sleep, moderate physical and thermal stress, and managing mental stress—you can add an estimated 10 to 15 years to your lifespan.

44. Embrace Carpe Diem Mindset

Live each day as if it’s a miracle and time is short, adopting a ‘Carpe Diem’ motto multiple times daily to motivate action against ill health and death.

45. Use NMN for Alertness

Take NMN (nicotinamide mononucleotide) in the morning to stimulate alertness, energy, and help reset your body clock, which can also aid in managing jet lag.