← FoundMyFitness

#076 Building Muscle with Resistance Exercise and Reassessing Protein Intake | Stuart Phillips, PhD

Jun 29, 2022 1h 56m 32 insights
<p>Stuart Phillips, PhD, is a professor of kinesiology at McMaster University in Hamilton, Ontario, Canada, where he also serves as the director of the Physical Activity Centre of Excellence. His research centers on the roles exercise and nutrition play in influencing human skeletal muscle protein turnover and how these lifestyle factors influence body composition, especially as we age.</p> <p><strong>In this episode, we discuss:</strong></p> <ul> <li><strong>(00:00)</strong> Introduction to Dr. Stuart Phillips</li> <li><strong>(07:16)</strong> Why muscle is important for longevity</li> <li><strong>(14:34)</strong> Is the importance of muscle mass (per se) overstated?</li> <li><strong>(16:48)</strong> Is the RDA on protein too low?</li> <li><strong>(19:03)</strong> Minimum vs. optimal protein intake (for athletes)</li> <li><strong>(19:29)</strong> Why older adults need more protein</li> <li><strong>(24:52)</strong> Caloric restriction vs. higher protein for aging</li> <li><strong>(28:04)</strong> What is a catabolic crisis?</li> <li><strong>(29:40)</strong> Effects of space flight on muscle</li> <li><strong>(36:16)</strong> Practical tips for protein intake</li> <li><strong>(39:34)</strong> Protein timing and the anabolic window</li> <li><strong>(41:27)</strong> Most important factors for hypertrophy</li> <li><strong>(43:57)</strong> Should we supplement leucine?</li> <li><strong>(45:46)</strong> Does plant protein support hypertrophy?</li> <li><strong>(56:30)</strong> Causes of anabolic resistance</li> <li><strong>(58:22)</strong> What types of exercise and how much?</li> <li><strong>(01:06:56)</strong> Protein and rest as tools for recovery</li> <li><strong>(01:08:14)</strong> Mechanisms of muscle protein synthesis and breakdown</li> <li><strong>(01:08:31)</strong> Does rapamycin inhibit hypertrophy?</li> <li><strong>(01:13:07)</strong> What is Dr. Phillips doing to age well?</li> <li><strong>(01:15:25)</strong> Hormonal responses to exercise</li> <li><strong>(01:17:09)</strong> Sex differences in hypertrophy</li> <li><strong>(01:19:38)</strong> Effect of menopause on muscle</li> <li><strong>(01:20:03)</strong> Do testosterone boosters work?</li> <li><strong>(01:21:56)</strong> Does growth hormone improve muscle?</li> <li><strong>(01:26:30)</strong> Androgen replacement therapy (benefits vs. drawbacks)</li> <li><strong>(01:31:17)</strong> Mental health benefits of exercise</li> <li><strong>(01:31:54)</strong> Anti-catabolic effects of heat</li> <li><strong>(01:38:19)</strong> Molecular causes of sarcopenia</li> <li><strong>(01:42:35)</strong> Anti-catabolic effects of omega-3</li> <li><strong>(01:48:57)</strong> Brain and muscle effects of creatine</li> </ul> <p><a href="https://www.youtube.com/watch?v=r8DSpOd0NZc">Watch this episode on YouTube</a></p> <p><a href="https://www.foundmyfitness.com/episodes/stuart-phillips">Show notes and transcript</a></p> <p>Join over 300,000 people and get the latest distilled information straight to your inbox weekly: <a href="https://www.foundmyfitness.com/newsletter">https://www.foundmyfitness.com/newsletter</a></p> <p>Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A's with Rhonda and more: <a href="https://www.foundmyfitness.com/crowdsponsor">https://www.foundmyfitness.com/crowdsponsor</a></p>
Actionable Insights

1. Follow Exercise Guidelines

Aim for 150 minutes of moderate to vigorous exercise and two days of strengthening activities per week to gain an average of four extra years of life and extend your health span.

2. Engage in Resistance Exercise

Even very old individuals (90-99 years old) can significantly improve gait speed and strength through resistance exercise, which is crucial for maintaining function and preventing decline.

3. Optimize Protein Intake

Aim for a minimum of 1.2 grams of protein per kilogram of body weight per day, and potentially up to 1.6 g/kg for athletes and older adults, as the current RDA (0.8 g/kg) is considered a minimal intake, not optimal for muscle support, especially with age.

4. Avoid Disuse and Bed Rest

Periods of disuse, such as bed rest during hospitalization or prolonged inactivity, dramatically accelerate muscle loss, especially in older adults, making recovery difficult and leading to a steeper decline.

5. Stay Active to Combat Resistance

Being physically active, including both aerobic and resistance exercise, is crucial for maintaining vascular insulin sensitivity and combating age-related anabolic resistance, which makes muscles less responsive to protein.

6. Quit Smoking for Health

Giving up smoking is a crucial step for improving health and extending lifespan, as it is a major factor in shortened lifespan and poor quality of life.

7. Maintain Healthy Body Weight

Strive to maintain a healthy body weight, avoiding excessive weight gain, as this is a fundamental step towards aging well and overall health.

8. Preserve Muscle for Health

Muscle mass, a highly hydrated tissue, is critical for overall health, especially as one ages, and its preservation is vital.

9. Prevent Frailty with Muscle

Maintaining muscle mass is critical for health and is an important component of the frailty index, which is a strong predictor of mortality in older adults.

10. Manage Chronic Inflammation

Control chronic low-grade inflammation, as it contributes to anabolic resistance and can hinder the effectiveness of nutritional and exercise interventions for muscle health.

11. Resistance Train Regularly

Perform resistance training at least twice a week for 30-45 minutes, aiming for high levels of effort until fatigue, as this is a major driver of strength and muscle gains, with three times a week offering even greater benefits.

12. Supplement Omega-3s

Supplementing with high-dose omega-3 fatty acids can be anti-catabolic, helping to mitigate muscle atrophy during disuse and aiding quicker recovery, particularly beneficial for older populations.

13. Supplement Vitamin D

Supplement with Vitamin D, especially in winter months or northern latitudes, due to widespread deficiency and its crucial role as a steroid hormone regulating numerous genes beyond bone health.

14. Consider Creatine Monohydrate Supplementation

Creatine monohydrate is a safe and effective supplement for muscle growth and cognitive performance, even for those not physically active, with a recommended dose of 4-5 grams per day.

15. Build Muscle Reserves Early

Accumulate muscle mass through concerted resistance exercise in your younger years (30s-70s) to create a higher plateau, which helps buffer against age-related muscle loss and functional decline.

16. Prioritize Leucine Intake

Leucine, an essential branched-chain amino acid, acts as a potent trigger for muscle protein synthesis, and older individuals may require more leucine or higher quality protein to stimulate this process effectively.

17. Boost Older Adult Breakfast Protein

Older adults, especially women, should increase protein intake at breakfast with nutrient-dense sources like Greek yogurt or eggs to achieve a more even protein distribution throughout the day.

18. Total Protein Trumps Timing

For most people, the total daily protein intake is more important than precise timing; however, elite athletes may benefit from even distribution of protein throughout the day.

19. Follow 3 R’s for Recovery

After exercise, prioritize recovery by rehydrating with fluids, refueling with carbohydrates, and repairing muscles with protein, as these macronutrients are the primary drivers of the restorative process.

20. Eat Well 80% of Time

Pay attention to what you eat 80% of the time, focusing on less red meat, more fish, and fewer refined carbohydrates, allowing for occasional indulgences.

21. Reduce Alcohol Intake

Reduce alcohol consumption to improve overall health, as excessive drinking negatively impacts longevity and well-being.

22. Fast Before Bedtime

Not eating two to three hours before bed can be beneficial for most people, as insulin sensitivity is lower in the evening, allowing for a period of digestive rest.

23. Increase Protein in Deficit

When in a caloric deficit, consider increasing protein intake to help counteract the catabolic effects on muscle, as calorie deficits can accelerate muscle breakdown.

24. Enhance Plant Protein Absorption

Cooking, sprouting, and fermentation of plant-based proteins like beans and legumes can liberate proteins and reduce anti-nutritional effects, making them more bioavailable and closer in quality to animal proteins.

25. Begin with Bodyweight Exercises

You don’t need a gym to do resistance workouts; start with bodyweight exercises like air squats or wall push-ups to overcome barriers and initiate physical activity.

26. Use Sauna for Muscle Health

Regular sauna use or heat exposure can alleviate muscle atrophy by activating heat shock proteins, which help prevent protein misfolding and support muscle health, potentially synergizing with exercise benefits.

27. Sauna for Mental Well-being

Sauna use can improve mental well-being, including reducing anxiety and depressive symptoms, with effects comparable to some pharmaceutical interventions.

28. Consider Protein Supplements

If unable to meet protein needs through whole foods, protein supplements are a convenient and useful option, especially for older adults with reduced appetite or difficulty chewing.

29. Avoid Testosterone Boosters

Testosterone-boosting supplements are generally ineffective and a waste of money; focus on resistance training instead, as normal fluctuations in testosterone do not significantly drive muscle protein synthesis.

30. Avoid BCAA Supplements

Branch chain amino acid (BCAA) supplements are largely ineffective because only leucine is the important component for muscle protein synthesis, and if you’re already consuming a high-protein diet, they are redundant.

31. Caution with Exogenous Hormones

Be cautious with exogenous hormones like steroids and growth hormone, as their super-physiologic levels can lead to uncontrolled growth and potentially increase cancer risk, despite their muscle-building effects.

32. Leucine for Older Adults

For older individuals struggling to consume enough protein, supplementing with 3-4 grams of leucine per meal can enhance muscle protein synthesis, mimicking the effect of a larger protein dose.