<p><strong>Dr. Aubrey de Grey</strong></p> <p>Dr. Aubrey de Grey is a biomedical gerontologist and the founder of the SENS research foundation which aims to find technologies that can repair the various types of damage that occur during the aging process.</p> <p class="p1">In this episode, we discuss...</p> <ul> <li class="p1"><strong>00:00:00</strong> - Introduction</li> <li class="p1"><strong>00:02:27</strong> - How to understand aging</li> <li class="p1"><strong>00:08:14</strong> - Epigenetic modifications accommodate cellular aging</li> <li class="p1"><strong>00:18:24</strong> - Inflammation is a double-edged sword<em><span class="Apple-converted-space"> </span></em></li> <li class="p1"><strong>00:24:00</strong> - Parabiosis has the potential to slow aging </li> <li class="p1"><strong>00:31:35</strong> - Lifestyle factors can only extend lifespan so far</li> <li class="p1"><strong>00:36:49</strong> - Future of Crispr/Cas9 in aging research</li> <li class="p1"><strong>00:40:56</strong> - Utilizing pluripotent stem cells from the placenta</li> </ul> <p>You can find Aubrey on Twitter at @aubreydegrey, and his foundation at <a href="http://www.sens.org">www.sens.org</a>.</p> <p><span style="font-weight: 400;">If you're interested in learning more, you can read the full show notes here: <a href="https://www.foundmyfitness.com/episodes/aubrey-de-grey">https://www.foundmyfitness.com/episodes/aubrey-de-grey</a></span></p> <p><span style="font-weight: 400;">Join over 300,000 people and get the latest distilled information straight to your inbox weekly:</span> <a href="https://www.foundmyfitness.com/newsletter"><span style="font-weight: 400;">https://www.foundmyfitness.com/newsletter</span></a></p> <p><span style="font-weight: 400;">Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A's with Rhonda and more:</span> <a href="https://www.foundmyfitness.com/crowdsponsor"><span style="font-weight: 400;">https://www.foundmyfitness.com/crowdsponsor</span></a></p>
Actionable Insights
1. Prioritize Sleep for Brain Health
Ensure adequate sleep to allow the brain’s glymphatic system to actively clear out waste products like amyloid plaques and other extracellular aggregates, which accumulate during aging.
2. Optimize Micronutrient Intake
Consume optimal amounts of essential micronutrients, including minerals and vitamins, as they are crucial for running your metabolism and enabling enzymes that repair damage.
3. Maintain Healthy Lifestyle
Adopt a good diet, specifically eating your greens, and engage in regular exercise. Additionally, avoid excessive drinking and smoking to support overall health, which may extend lifespan by a couple of years.
4. Avoid Obesity
Prevent obesity, as it is strongly associated with a significant reduction in lifespan, potentially ranging from a 7-year to a 14-year reduction.
5. Cautious Inflammation Modulation
In older age (60s-70s), be cautious about dampening or excessively boosting your inflammatory response. A strong inflammatory response is necessary to fight infections, and altering it could increase risks like pneumonia.
6. Support FoundMyFitness
Consider contributing $5 a month to FoundMyFitness via patreon.com/foundmyfitness or foundmyfitness.com to help fund production and enable the creation of more in-depth content.
7. Explore SENS Research
Visit SENS.org (S-E-N-S.org) to learn more about the SENS Research Foundation and its work on preventing and reversing aging through damage repair technologies.
8. Attend SENS Conference
Consider attending the SENS Research Foundation conference in Burlingame from August 19th-21st. Registration is open, and it will cover all aspects of rejuvenation biotechnology with academic and industry participation.