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The Science of Cannabis: Does It Help or Hurt With Anxiety? Is It Addictive? What's the Safest Way To Use It? | Dr. Riley Kirk

Dec 8, 2025 1h 14m 43 insights
<p dir="ltr">Everything you want to know about cannabis, but were afraid to ask.</p> <p><strong> </strong></p> <p dir="ltr">Dr. Riley Kirk is a cannabis research scientist and educator with a Ph.D. in pharmaceutical sciences, specializing in natural product chemistry. Her new book is <a href="https://tracking.us.nylas.com/l/f89f725a8c1749ab911631e1d24ac2c2/1/a26799ad08af529bba55e2d94ca1f08d93b635ccae79012f648361962d6e84c2?cache_buster=1751381368"> Reefer Wellness: Understanding Cannabis Science, Culture, and Medicines</a>.</p> <p dir="ltr"> </p> <p dir="ltr">In this episode we talk about:</p> <ul> <li dir="ltr">The endocannabinoid system – and how it works in the body</li> <li dir="ltr">The science-backed health benefits of cannabis</li> <li dir="ltr">The risks of cannabis use – including questions about psychosis, schizophrenia, and specific risks for adolescents</li> <li dir="ltr">The fascinating history of the cannabis plant </li> <li dir="ltr">The criminalization, racism and propaganda machine within that history</li> <li dir="ltr">The legality of cannabis now in the US</li> <li dir="ltr">Different modes of use</li> <li dir="ltr">Where to source your products</li> <li dir="ltr">And much more</li> </ul> <p><strong><br /> <br /></strong></p> <p dir="ltr">Join Dan's online community <a href="http://www.danharris.com/">here</a></p> <p dir="ltr">Follow Dan on social: <a href="https://bit.ly/3tGigG5">Instagram</a>, <a href="https://bit.ly/3FOA84J">TikTok</a></p> <p dir="ltr">Subscribe to our <a href="https://bit.ly/3FybRzD">YouTube Channel</a></p> <p><strong><br /> <br /></strong></p> <p dir="ltr">Additional Resources: </p> <ul> <li dir="ltr"><a href="https://www.bioactivepodcast.com/">Bioactive podcast</a></li> <li dir="ltr"><a href="https://tracking.us.nylas.com/l/f89f725a8c1749ab911631e1d24ac2c2/0/53380cb74278c7b79c24105d80a19ae28e173628c3f8870feabce2d21a7d89dc?cache_buster=1751381368"> @cannabichem</a></li> <li dir="ltr"><a href="https://www.appliedpharmacognosy.org/">The Network of Applied Pharmacognosy (NAP)</a></li> </ul> <p><strong><br /> <br /></strong>Thanks to our
Actionable Insights

1. Start Low, Go Slow

When trying cannabis, especially if new or sensitive, begin with very low doses and gradually increase to find your optimal effect, as you can always take more but cannot easily reverse an excessive dose.

2. Manage THC Dosing for Anxiety

Use low doses of THC or CBD products to help with anxiety, as too much THC can cause panic attacks and make anxiety worse.

3. Avoid Cannabis if Schizophrenia Risk

If you have a genetic predisposition to schizophrenia (family history), avoid cannabis products as THC can decrease the age of onset for the first schizophrenic episode, though it doesn’t cause the condition itself.

4. Delay Cannabis Use in Adolescence

Young people should delay cannabis use as long as possible, as there is data suggesting it can alter brain development (gray to white matter ratio) in developing brains.

5. Warn Adolescents About High-THC Vapes

Educate young people about the increased risks of high-THC vape carts, which are discreet, easy to overuse, and deliver unbalanced, potent doses compared to traditional flower.

6. Do Not Dose Pets

Never give THC products to pets, as it is unsafe and can cause distress, impaired movement, nausea, and loss of bowel control; CBD is generally safer for animals.

7. Avoid Driving as New User

If you are new to cannabis or have a low tolerance, do not drive after consumption, as it significantly impairs hand-eye coordination and motor control.

8. Dose CBD at 200mg+

To experience the medicinal benefits of CBD for conditions like anxiety or seizures, aim for doses of 200 milligrams or more, as lower doses are not typically supported by research.

9. CBD is Safe at High Doses

CBD is generally safe and does not cause a high, so you can safely experiment with higher doses (200mg+) without fear of overwhelming your brain.

10. Balance THC with CBD Products

To minimize detriments and maximize benefits, use CBD products alone or mix them with THC products to reduce the overall THC intake and help protect the brain from overstimulation.

11. Sensitive to THC? Use Hemp

If you are very sensitive to THC, opt for CBD-dominant hemp flower or CBD products, as CBD can protect your brain from overstimulation and balance out THC’s effects.

12. Avoid Synthetic Hemp Cannabinoids

Do not use synthetic cannabinoids (e.g., HHC, THCP) found in some hemp products, especially if new to cannabis, as they are not under the same testing regulations as legal cannabis.

13. Personalize Your Cannabis Use

Recognize that cannabis is a highly individualized medicine; experiment carefully with different strains and doses to understand how it uniquely affects your body.

14. Curate Your Cannabis Experience

Take control of your cannabis use by selecting different products for different times of day or specific desired effects (e.g., social situations, relaxation, mood enhancement).

15. Choose Strains Carefully

Be aware that different cannabis strains can have different effects; some may cause anxiety while others do not, so choose based on desired outcomes.

16. Avoid Sativas if Anxious

If you experience anxiety from sativa-type cannabis, avoid them as their uplifting profile can increase heart rate, and instead seek out more calming varieties.

17. Match Strain Type to Effect

Use ‘sativa’ to seek uplifting, energetic effects and ‘indica’ for mellow, relaxing effects, understanding that most modern products are hybrids.

18. Select Uplifting Strains for Activity

For activities like exercise or creative work, choose uplifting sativa-type varieties, but be mindful of dosing to avoid counterproductive effects.

19. Avoid High Doses for Motivation

High doses of cannabis can lead to lightheadedness or reduced motivation, making you want to relax rather than engage in active pursuits.

20. Use Dry Herb Vapes

For the healthiest inhalation method, use a dry herb vaporizer, which heats cannabis flower to vaporize compounds without combustion byproducts.

21. Prefer Flower Over Distillate Vapes

When vaping, prioritize cannabis flower over distillate vape oils, as distillate often lacks the full spectrum of beneficial plant compounds and may contain heavy metals from the cart.

22. Choose Method by Desired High

Select your cannabis consumption method (edibles vs. smoking/vaping) based on whether you prefer a body high (edibles) or a more cerebral head high (smoking/vaping).

23. Consider Edibles/Tinctures (with caveat)

Edibles and tinctures are good alternatives to smoking, but be aware that up to 20% of people may not feel the effects of edibles due to genetic differences in liver enzymes.

Obtain cannabis products from legal dispensaries that provide tested products with clear cannabinoid profiles, or consider growing your own for a balanced, known-origin product.

25. Consult Dispensary Professionals

Utilize the expertise of staff at legal dispensaries to help you navigate product choices, dosing, and find cannabis options tailored to your specific needs and conditions.

26. Grow Your Own Cannabis

Cultivating your own cannabis can lead to a deeper appreciation for the plant, offering a more balanced product and a personal connection to its production.

27. Use Cannabis for Chronic Pain

Cannabis, particularly THC, can activate the endocannabinoid system to help reduce chronic pain by interrupting excessive pain signals sent to the brain.

28. Consider CBD for Seizures

CBD has been extensively studied and is a highly effective medicine for rare and severe forms of seizures.

29. Use Cannabis for Sleep

Cannabis products containing THC or CBN can help you fall asleep faster and stay asleep longer, though it may affect sleep quality initially.

30. Prioritize Any Sleep Over No Sleep

If you struggle with insomnia, using cannabis to achieve sleep, even if it reduces REM sleep, is generally more beneficial than getting no sleep at all.

31. Cannabis for Menopause Symptoms

Cannabis can help women experiencing menopause by bringing regulation to dysregulated systems, balancing hormones, mood, and sleep.

32. Enhance Creativity with Cannabis

Cannabis can help achieve a ‘flow state’ by reducing distracting thoughts, potentially enhancing creativity and focus for tasks like art or exercise, especially at low doses.

33. Use Cannabis as a Pre-Workout

Consider using low-dose cannabis as a pre-workout to help get into a ‘flow state’ and increase blood flow during exercise.

34. Stimulate Appetite with Cannabis

For conditions like cancer or HIV/AIDS where appetite stimulation is needed, cannabis (specifically THC) is a science-backed medicinal benefit.

35. Recognize Unhealthy Cannabis Use

If cannabis use prevents you from socializing, leaving home, eating, or functioning, it may indicate unhealthy reliance; consider lowering your dose, seeking therapy, or examining if it’s escapism.

36. Assess Use for Addiction Signs

Differentiate between dependency and addiction by evaluating if cannabis use is causing harm to your life, relationships, or finances; if it’s beneficial, dependency is acceptable.

37. Beware of Anxiety if Predisposed

If you have a history of anxiety, be especially cautious with cannabis use, as you are more susceptible to experiencing anxiety or panic attacks from it.

38. Tolerance Reduces Anxiety Risk

Regular cannabis users (those with tolerance) are less likely to experience anxiety from cannabis compared to sporadic or new users.

39. Be Aware of Lung Health Risks

Understand that smoking cannabis, like any inhaled substance, can produce tar and potentially impact lung health over time, leading to phlegm or breathing difficulties.

40. Discuss Cannabis with Children Openly

When discussing cannabis with children, encourage them to wait as long as possible, suggest cannabis as a safer alternative if they feel compelled to use substances, and foster open communication.

41. Use ‘Cannabis’ Not ‘Marijuana’

Be mindful of the term ‘marijuana’ due to its historical roots in racism and its use to target Mexican-Americans; prefer the term ‘cannabis’ instead.

42. Support Cannabis Justice Initiatives

Advocate for and support organizations like the Last Prisoner Project that work to free individuals incarcerated for cannabis-related charges, acknowledging the ongoing racial disparities in arrests.

43. Accept If Cannabis Isn’t Right

If you consistently have negative experiences with cannabis, it’s perfectly acceptable to avoid it, as not everyone reacts well to the plant.